Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

CircuMax Gold Ingredients & Drug Interactions

by YES Youth Extension Solutions

CircuMax Gold label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CircuMax Gold against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CircuMax Gold is a dietary supplement by YES Youth Extension Solutions with 4 active ingredients. Its ingredients are commonly taken for high blood pressure, exercise and athletic performance, heart and circulation support.Based on those ingredients, 1,026 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet, Bacillus subtilis DE111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CircuMax Gold by YES Youth Extension Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with CircuMax Gold by YES Youth Extension Solutions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CircuMax Gold by YES Youth Extension Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

CircuMax Gold has 4 active ingredients. Beet is included for its potential benefits on athletic performance and exercise recovery.

Bacillus subtilis DE111 is a probiotic — a beneficial live bacterium — added for digestive and immune support. The product also contains Nitro Rocket and Careflow, though we don't have detailed information on their specific roles in the formula.

The remaining ingredients are inactive excipients: citric acid, natural flavors, malic acid, silicon dioxide, and stevia leaf extract, which help with taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: circulation and nitric oxide production support.
  • We looked for evidence on: Hypertension, Coronary heart disease (CHD), Dyslipidemia, Pulmonary hypertension, Raynaud syndrome, Athletic performance — and 4 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beet is rated "Possibly Effective" for Exercise-induced muscle soreness.
  • Also on file: Beet is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Dyslipidemia, Pregnancy-induced hypertension, Raynaud syndrome, and more.

Beet shows possibly effective evidence for athletic performance and exercise-induced muscle soreness, meaning some clinical support exists but the evidence isn't definitive. For other uses — chronic obstructive pulmonary disease, cholesterol levels, and cognitive function — the evidence is either insufficient or leans toward ineffective.

Bacillus subtilis DE111 is possibly effective for antibiotic-associated diarrhea; for other conditions in this formula, the evidence is insufficient. We don't have effectiveness data on file for Nitro Rocket or Careflow.

The evidence, ingredient by ingredient Beet Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beet is generally well tolerated as a food, but concentrated supplements lack robust safety data — use caution and talk with your doctor before starting if you're new to high-dose forms. The most common side effect is red or black stools, which isn't harmful; rarely, very large amounts could theoretically cause low calcium or kidney damage.

Bacillus subtilis DE111 is generally well tolerated in healthy adults, though one headache was reported in a trial and diarrhea very rarely. Serious infections (bacteremia, meningitis) have been reported with a specific strain consumed in large amounts by people with weakened immunity — your individual risk depends on your health status.

Safety data for concentrated Bacillus subtilis supplements is limited, so check with your doctor before use.

Side effects, ingredient by ingredient Beet Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Beet, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1,027 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use drugs metabolized by the liver enzyme CYP3A4, blood pressure medications, CYP1A2-dependent drugs, or antibiotic drugs. Beet may raise levels of some CYP3A4 medications and lower blood pressure further; Bacillus subtilis might reduce antibiotic effectiveness if taken together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with athletic performance and exercise soreness if you tolerate it well, but it carries Moderate interactions with certain liver-metabolized drugs and antibiotics. Before you start, check your exact medications — especially any that treat high blood pressure, any that your doctor says work through liver enzymes, or any antibiotics you take regularly — with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CircuMax Gold, straight from the product label.

Brand YES Youth Extension Solutions
Net contents 6.7 Ounce(s); 190 Gram(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 306996
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CircuMax Gold by YES Youth Extension Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.3 Gram(s)
Maximum serving Sizes:
6.3 Gram(s)
Servings per container
30
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Beet4000 mg--
Bacillus subtilis DE11111 mg--
Nitro Rocket1000 mg--
Careflow100 mg--

Other ingredients: Citric Acid, Natural Flavors, Malic Acid, Silicon Dioxide, Stevia Leaf Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Please consult your healthcare practitioner before using any nutritional supplement, especially if you are taking medications on a regular basis, anticipate surgery, or are otherwise under medical supervision. Product not intended for use by children under 18 or those who are pregnant or lactating.

Product not intended for use by children under 18 or those who are pregnant or lactating.

Manufactured in a facility that produces milk, soy, wheat, eggs, peanuts, fish and tree nuts.

Formulation

Your daily circulation secret CircuMax gold combines four superstar ingredients into one tasty drink.

Made with Non-GMO ingredients Gluten free

Vegan

Nitric Oxide Support Formula

Color, taste and texture may vary.

Suggested/Recommended/Usage/Directions

Suggested use: Mix one serving (scoop) with 6-8 oz. water or favorite beverage.

Formula

Non-GMO organic beet root powder Enhances circulation by stimulating nitric oxide production in the body Nitro Rocket Arugala The highest nitrate vegetable on the planet. DE111 Bacillus subtilis A well-studied probiotic strain to help promote healthy balanced microbiome. CareFlow mango fruit powder Improves microcirculation

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

To reorder call 800-720-1023

Brand IP Statement(s)

Copyright 2022 Youth Extension Solutions

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CircuMax Gold by YES Youth Extension Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CircuMax Gold label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CircuMax Gold by YES Youth Extension Solutions

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.3 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beet

Interacts with
863 drugs
4000 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet monograph & interactions

Bacillus subtilis DE111

Interacts with
182 drugs
11 mg per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis DE111 monograph & interactions

Nitro Rocket

1000 mg per serving Form: Arugula Extract

Careflow

100 mg per serving Form: Mango

Other (inactive) ingredients: Citric Acid, Natural Flavors, Malic Acid, Silicon Dioxide, Stevia Leaf Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

CircuMax Gold by YES Youth Extension Solutions Drug Interactions

Want to check YOUR meds against CircuMax Gold?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,026Drugs
809 Moderate 217 Minor

Ingredients driving the most interactions

Beet 863
Bacillus subtilis DE111 182

Individual Drug Interactions

The ingredients in CircuMax Gold interact with 1,026 drugs. Click any drug to see the details.

2 of the 4 ingredients in CircuMax Gold interact with drugs. Each result below shows which ingredient is responsible. Beet Bacillus subtilis DE111

Each ingredient & the kinds of drugs it affects

For each ingredient in CircuMax Gold with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 863 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet full monograph & interactions

Bacillus subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis DE111 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CircuMax Gold, from the product label.

YES Youth Extension Solutions

See all YES Youth Extension Solutions products
Name
Youth Extension Solutions (YES)
Street Address
240 Jennifer Dr. Ste 105
City
Cottonwood
State
AZ
ZipCode
86326
Phone Number
800-720-1023
Web Address
www.yesover100.com
Pharmacist Counseling Corner

CircuMax Gold by YES Youth Extension Solutions: Common Questions

Does CircuMax Gold by YES Youth Extension Solutions interact with any medications?
Yes. Based on its ingredients, CircuMax Gold has a known interaction with 1,026 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CircuMax Gold contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the red or black color in my stool after taking this?
That's beet — it's harmless. Beet supplements commonly turn stools red or black, and it's not a sign of bleeding or a problem.
Can I take this if I'm on antibiotics?
The Bacillus subtilis in this product may not work as well if you take antibiotics at the same time, since antibiotics can kill the live bacteria. Talk to your doctor or pharmacist about timing — they may suggest you separate the doses.
Is beet safe to take as a concentrated supplement, or just as food?
Beet as food is fine and well tolerated, but concentrated supplements lack robust safety data. Use caution and discuss it with your doctor, especially if you take medications or have health concerns.
Does this actually improve athletic performance?
Beet, the main active ingredient, has possibly effective evidence for athletic performance and exercise soreness — meaning some clinical support exists, but the evidence isn't definitive. Results vary by person.
What is Bacillus subtilis DE111 and why is it in here?
It's a probiotic — a live beneficial bacterium — added for digestive and immune support. It's possibly effective for diarrhea caused by antibiotics.
Can I take this if I have kidney problems?
Very large amounts of beet could theoretically cause kidney damage, so if you have kidney concerns, talk with your doctor before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CircuMax Gold is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CircuMax Gold label
Go deeper

The Full Monographs Behind CircuMax Gold’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beet

Interacts with 863 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

CircuMax Gold's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beet 10 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  3. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  4. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  5. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  6. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  7. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  8. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  9. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  10. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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