Interactions on record — worth a quick check against your medications. Based on 8 of 15 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes Ingredients & Drug Interactions

by Top Secret Nutrition

Digestive Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Enzymes is a dietary supplement by Top Secret Nutrition with 15 active ingredients. Its ingredients are commonly taken for improving mineral absorption, breaking down phytic acid (phytate) in grains and legumes, supporting digestion of plant-based foods.Based on those ingredients, 1,167 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Lactobacillus acidophilus, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Enzymes by Top Secret Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes by Top Secret Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Enzymes by Top Secret Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 15 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (114.70 mg) without saying how much of each component you get.

This product contains 15 ingredients, including a proprietary enzyme blend. The active ingredients are digestive enzymes — Protease, Lipase, and Amylase — along with Bromelain (from pineapple), which breaks down proteins and fats to support digestion.

You'll also find Lactase (breaks down milk sugar), Phytase (breaks down phytic acid), Alpha Galactosidase (breaks down complex sugars), and Invertase (breaks down sucrose). Fructooligosaccharides (FOS) is a prebiotic fiber meant to feed beneficial gut bacteria.

Lactobacillus acidophilus is a probiotic — live beneficial bacteria. Bioperine (black pepper extract) is included to enhance nutrient absorption.

The inactive ingredients are Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, and Vegetable Cellulose.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and enzyme function.
  • We looked for evidence on: Dyspepsia, Flatulence, Lactose intolerance, Diarrhea, Constipation, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.

The evidence for most ingredients is weak or absent. Lactase is Effective for lactose intolerance — if you have trouble digesting milk, this enzyme can help break down the lactose.

Lactobacillus acidophilus is Possibly Effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection. For the other active enzymes and FOS, the data we hold show Insufficient Reliable Evidence — meaning the research hasn't been strong enough to establish whether they work for their intended digestive support roles.

For Bioperine and Bromelain, effectiveness ratings are also Insufficient Reliable Evidence for the conditions listed.

The evidence, ingredient by ingredient Phytase Proteolytic Enzymes (proteases) Lipase Lactase Bromelain Fructo-oligosaccharides (fos) Lactobacillus Acidophilus Black Pepper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated. FOS commonly causes gas, bloating, flatulence, and abdominal pain, especially at higher doses — studies show symptoms are usually mild below 10 grams daily.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though it may cause gastrointestinal side effects like abdominal pain, bloating, diarrhea, or burping. Bromelain may cause diarrhea, flatulence, gastric upset, and headache.

Bioperine (black pepper) can cause a burning aftertaste, indigestion, or cough if inhaled. Protease enzymes and Phytase have limited human safety data on supplements.

Phytase exposure in occupational settings has caused allergic asthma and lung inflammation in rare cases. Protease has rarely caused allergic reactions in sensitive individuals.

For pregnancy: Lactobacillus acidophilus is Possibly Safe, and Bioperine is Likely Safe in normal food amounts. Bromelain, Protease, and other enzymes lack sufficient safety data — check with your doctor or pharmacist before use during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Phytase Proteolytic Enzymes (proteases) Lipase Lactase Bromelain Fructo-oligosaccharides (fos) Lactobacillus Acidophilus Black Pepper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 8 matched ingredients can interact with medications — Lactobacillus Acidophilus, Black Pepper, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use heart medications like propranolol (Inderal), seizure drugs like phenytoin (Dilantin), blood thinners or antiplatelet drugs (such as warfarin or aspirin), asthma or heart medications like theophylline, antiretroviral drugs like nevirapine (Viramune), antibiotics like rifampin (Rifadin) or tetracyclines, the transplant drug cyclosporine (Neoral, Sandimmune), cholesterol drugs like atorvastatin (Lipitor), or sleep aids like pentobarbital (Nembutal). These are the medication types with documented interactions in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme blend is most useful if you have lactose intolerance (the Lactase will help) or if you're taking antibiotics (the Lactobacillus acidophilus is Possibly Effective for antibiotic-related diarrhea — but time your doses at least 2 hours away from antibiotics). If you take any heart, seizure, blood-thinning, antiretroviral, or asthma medications, check your specific drugs against the interaction tool on this page before starting, since Bioperine and Bromelain carry documented risks.

Talk with your doctor or pharmacist before use, especially if you're pregnant, breastfeeding, or have a serious digestive condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes, straight from the product label.

Brand Top Secret Nutrition
Barcode (UPC) 811226021232
Net contents 90 Veggie Cap(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 259090
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes by Top Secret Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
811226021232
IngredientAmount% DV
Proprietary Blend114.7 mg--
Fructooligosaccharides100 mg--
Lactobacillus acidophilus0 NP--
Bioperine2 mg--
Phytase0 NP--
Protease0 NP--
Glucoamylase0 NP--
Protease0 NP--
Lipase0 NP--
Protease Concentrate0 NP--
Amylase0 NP--
Alpha Galactosidase0 NP--
Lactase0 NP--
Bromelain0 NP--
Cellulase0 NP--
Invertase0 NP--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one (1) capsule with every meal in the day.

Precautions

Warning: Keep out of reach of children.

Use this product as a dietary supplement only.

Do not use if you are pregnant or nursing or if you have any medical condition.

Do not use if seal or package is broken.

Consult your physician prior to use if you have any medical condition.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa Corporation.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

TS Health

Formula

Full spectrum formula with prebiotics and probiotics

10 different digestive enzymes

Top Secret Nutrition Digestive Enzymes is a unique and comprehensive blend of non-animal source digestive enzymes plus Prebiotics and Probiotics to support overall gastrointestinal and urogenital health. The enzymes in Top Secret Nutrition Digestive Enzymes strengthen the body's ability to break down proteins, fats, carbohydrates, and fiber. The formula also includes Bioperine, that has been shown to support the body's natural absorption of nutrients.

FDA Statement of Identity

Dietary Supplement

Formulation

Helps absorption of nutrients Helps reduce bloating

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Enzymes by Top Secret Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Enzymes by Top Secret Nutrition

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

114.7 mg per serving

Fructooligosaccharides

No known
interactions
100 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Lactobacillus acidophilus

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Bioperine

Interacts with
1,019 drugs
2 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes by Top Secret Nutrition Drug Interactions

Want to check YOUR meds against Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,167Drugs
1,125 Moderate 42 Minor

Ingredients driving the most interactions

Bioperine 1,019
Lactobacillus acidophilus 182
Bromelain 141

Individual Drug Interactions

The ingredients in Digestive Enzymes interact with 1,167 drugs. Click any drug to see the details.

3 of the 15 ingredients in Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Bioperine Lactobacillus acidophilus Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Enzymes, from the product label.

Top Secret Nutrition

See all Top Secret Nutrition products
Name
Top Secret Nutrition, LLC.
Street Address
11490 Interchange Circle North
City
Miramar
State
FL
ZipCode
33025
Phone Number
877.633.3830
Web Address
TopSecretNutrition.com
Pharmacist Counseling Corner

Digestive Enzymes by Top Secret Nutrition: Common Questions

Does Digestive Enzymes by Top Secret Nutrition interact with any medications?
Yes. Based on its ingredients, Digestive Enzymes has a known interaction with 1,167 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzymes contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my digestion?
The product contains digestive enzymes — protease, lipase, and amylase — meant to break down proteins, fats, and carbohydrates. However, the evidence for enzyme supplements in general is not strong enough for us to say they're definitely effective. Lactase is proven to help with lactose intolerance if that's your issue.
Is this safe if I take antibiotics?
It depends. The Lactobacillus acidophilus in this product may help prevent antibiotic-related diarrhea, which is a silver lining — but you should separate doses of antibiotics and this product by at least 2 hours, since antibiotics can kill the live bacteria. Talk to your pharmacist about timing before you start.
Will this cause gas or bloating?
Possibly. FOS (fructooligosaccharides) commonly causes gas, bloating, and abdominal discomfort, especially when you first start or at higher doses. These symptoms are usually mild under 10 grams daily. The Lactobacillus acidophilus and Bromelain may also cause bloating or flatulence in some people.
Can I take this during pregnancy?
Lactobacillus acidophilus is Possibly Safe in pregnancy. For the other ingredients — Bromelain, Protease, and most enzymes — there isn't enough safety data to know either way. Talk with your doctor or pharmacist before taking this product if you're pregnant.
What is Bioperine and why is it in here?
Bioperine is an extract from black pepper (piperine). It's added to supplements because research suggests it may increase how your body absorbs other nutrients. But it can also increase blood levels of certain medications, so it's important to check your drugs against the interaction tool if you're on any regular prescriptions.
Is there lactose in this product?
We don't have a full ingredient breakdown listing all allergens or milk derivatives. If you have a dairy allergy, contact the manufacturer directly or talk to your pharmacist to confirm the product is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes label
Go deeper

The Full Monographs Behind Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph →
Sources

Sources & How We Checked

Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 81 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
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Black Pepper 29 references
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Phytase 7 references
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  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
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Proteolytic Enzymes (proteases) 3 references
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Lipase 1 reference
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Bromelain 19 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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