Clear Muscle Next Gen Ingredients & Drug Interactions
by MuscleTech Performance Series
What is this page for?
First and foremost: checking Clear Muscle Next Gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Clear Muscle Next Gen is a dietary supplement by MuscleTech Performance Series with 2 active ingredients. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Clear Muscle Next Gen by MuscleTech Performance Series
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 2 active ingredients. Betaine Anhydrous is an amino acid compound that your body uses to help manage homocysteine, an amino acid in your blood.
BetaTOR is the other active ingredient, though we don't have detailed information on file about its role or how it works.
Does it work?
Insufficient evidence
Betaine Anhydrous is effective for homocystinuria (a rare genetic condition that raises homocysteine levels) and possibly effective for hyperhomocysteinemia (elevated homocysteine in the blood). For other uses listed — nonalcoholic fatty liver (NASH), colorectal adenoma, depression, and acid reflux (GERD) — the evidence isn't strong enough yet to rate.
We don't hold effectiveness data for BetaTOR.
How safe is it?
Well-documented data
Betaine Anhydrous is generally well tolerated at studied doses, but the safety data isn't extensive, so it's best to check with your doctor before starting. The most common side effects are body odor, diarrhea, nausea, vomiting, GI upset, and elevated cholesterol levels.
Cerebral edema (fluid in the brain) is rare but serious. There isn't enough data to know whether this product is safe during breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for Betaine Anhydrous. We couldn't check BetaTOR, so if you take any regular medications, run them through the tool on this page or ask your pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product may be worth considering if you're interested in supporting normal homocysteine levels, but talk to your doctor or pharmacist first — especially if you're pregnant, breastfeeding, or have any health conditions. Let us know your medications so we can double-check for any interactions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Clear Muscle Next Gen, straight from the product label.
| Brand | MuscleTech Performance Series |
|---|---|
| Barcode (UPC) | 631656608236 |
| Net contents | 84 Liquid Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 245695 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Clear Muscle Next Gen by MuscleTech Performance Series, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Betaine Anhydrous | 250 mg | -- |
| BetaTOR | 1000 mg | -- |
Other ingredients: Glycerin, modified Food Starch, Carrageenan, Sorbitol, purified Water, Natural flavors
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
The most effective muscle performance amplifier Whether you’re a fitness enthusiast, powerlifter, endurance athlete or bodybuilder, you know that faster muscle recovery leads to better performance, strength, endurance and lean muscle growth. Amino acids are the building blocks of muscle, which makes them critical to recovery. Now, what if you can make an amino acid better?
In fact, no amino acid or leucine pill is as extensively researched as BetaTOR, and it’s been shown across more than 10 peer-reviewed scientific publications to: Accelerate recovery Boost workout performance Enhance endurance performance Maximize peak power Increase anabolism by 70% Decrease catabolism by 58% Amplify squat strength Increase max 1-rep bench press Build 3.5 times the muscle
Accelerate muscle recovery & reduce muscle breakdown Clear Muscle Next Gen works for all types of hard-training fitness individuals! In fact, a clinical study on the key ingredient, BetaTOR, found it has the ability to increase protein synthesis by over 70% and reduce protein breakdown by 58% at the same time. This revolutionary ability primes your muscles for superior athletic results.
Extraordinary recovery & performance In one 12-week study at a leading university, well-trained individuals supplementing with the exact dose of BetaTOR found in Clear Muscle Next Gen increased overall performance as measured through vertical jump power output and Wingate peak power testing. BetaTOR was even shown to support recovery from intense training. In the same 12-week, randomized, double-blind, placebo-controlled clinical study, subjects taking BetaTOR in combination with exercise gained 16.3 lbs. of muscle. The placebo group only gained 4.6 lbs. That’s 3.5 times the muscle. The most researched performance pill Over 10 peer-reviewed clinical publications attest to the power of Clear Muscle Next Gen as the best performance formula on the market for recovery, performance, endurance, strength and lean muscle! Read the studies for yourself at: muscletech.com/clearmusclenextgen
Clear Muscle Next Gen works better the harder you train! Try the intense training program used in the study here: muscletech.com/trainhard
Performance & recovery amplifier Clinically shown to: Accelerate recovery Boost performance Enhance strength Build muscle
Made in the U.S.A. from international ingredients.
Formula
Introducing Clear Muscle Next Gen, which is made with exclusive BetaTOR, a unique metabolite and free-acid HMB derivative of the most powerful amino acid, leucine.
1,000mg BetaTOR
General Statements
New!
Muscletech research & development
Visit: mucletech.com/trainhard
Like us on Facebook Twitter@MuscleTEch Instagram MuscleTech
Suggested/Recommended/Usage/Directions
1-pill serving
Directions: Take 1 serving (1 softgel) 3 times daily (in the morning, mid-afternoon and evening). On workout days, take 1 of these servings 30 minutes before training. Do not exceed 3 servings (3 softgels) in a 24-hour period. To maximize your results, use the exact same training protocol as the subjects in the 12-week study.
FDA Statement of Identity
Dietary Supplement
Precautions
Warning: For adult use only. Consult a medical doctor before use if you have a medical condition and before starting a diet or exercise program.
Do not use if pregnant or nursing.
Keep out of the reach of children.
Do not use if packaging has been tampered with.
Storage
Store in a cool, dry place (60 degrees Fahrenheit to 80 degrees Fahrenheit).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
BetaTOR (HMB free acid) BetaTOR is a registered trademark of Metabolic Technologies, Inc. and is licensed from Metabolic Technologies, Inc. Uses of HMB are covered by pending patent applications owned by Metabolic Technologies, Inc.
Copyright 2018.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Clear Muscle Next Gen by MuscleTech Performance Series label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Clear Muscle Next Gen by MuscleTech Performance Series
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Liquid Softgel Capsule(s) Dosage formCapsule Servings per container84 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Betaine Anhydrous
No knowninteractions
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...
Betaine Anhydrous monograph & interactionsBetaTOR
Other (inactive) ingredients: Glycerin, Modified Food Starch, Carrageenan, Sorbitol, Purified Water, Natural flavors. These complete the product’s ingredient list but are not active constituents.
Clear Muscle Next Gen by MuscleTech Performance Series Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Clear Muscle Next Gen. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Clear Muscle Next Gen, from the product label.
MuscleTech Performance Series
See all MuscleTech Performance Series products- Name
- Iovate Health Sciences U.S.A. Inc.
- Street Address
- 1105 North Market Street, Suite 1330
- City
- Wilmington
- State
- DE
- ZipCode
- 19801
- Web Address
- muscletech.com
Clear Muscle Next Gen by MuscleTech Performance Series: Common Questions
Does Clear Muscle Next Gen by MuscleTech Performance Series interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does Betaine Anhydrous actually do?
What side effects might I see?
Is it safe to take while breastfeeding?
Can I take this if I'm pregnant?
Does it really work for muscle?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Clear Muscle Next Gen is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Clear Muscle Next Gen’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Clear Muscle Next Gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Betaine Anhydrous 11 references
- Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
- Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
- Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
- McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
- Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
- Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
- Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
- Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
- Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
- Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
- Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC