Interactions on record — worth a quick check against your medications. Based on 7 of 14 ingredients. Check your meds →
Dietary supplement

Amino Build Next Gen Watermelon Ingredients & Drug Interactions

by MuscleTech Performance Series

Amino Build Next Gen Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino Build Next Gen Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Amino Build Next Gen Watermelon is a dietary supplement by MuscleTech Performance Series with 14 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 355 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, Taurine, Coconut Water. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino Build Next Gen Watermelon by MuscleTech Performance Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino Build Next Gen Watermelon by MuscleTech Performance Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Amino Build Next Gen Watermelon by MuscleTech Performance Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 13 of its 13 active ingredients.
  • “2:1:1 BCAA Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Strength-Enhancing Compound” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Cell-Volumizing and Recovery Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

Amino Build Next Gen Watermelon contains 13 active ingredients. The main ones are amino acids—L-glutamine, L-alanine, taurine, and the branched-chain amino acids leucine, isoleucine, and valine (grouped in the "2:1:1 BCAA Matrix")—which support muscle function and recovery.

You'll also get sodium and potassium from sodium chloride and dipotassium phosphate, electrolytes that help with hydration and muscle function. Betaine anhydrous and coconut water round out the formula.

The product also contains several inactive ingredients (fillers and binders like malic acid, silicon dioxide, and citric acid) and is flavored and sweetened with artificial and natural flavoring, sucralose, and acesulfame-potassium.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Builds muscle and enhances exercise performance.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle strength, Muscle hypertrophy — and 1 related terms.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Betaine Anhydrous is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for these ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma.

Betaine anhydrous is effective for homocystinuria (a rare metabolic condition) and possibly effective for high homocysteine. Taurine is possibly effective for hepatitis and congestive heart failure, but possibly ineffective for obesity.

Sodium is likely effective for cystic fibrosis and possibly effective for kidney toxicity from amphotericin B. For the other ingredients—L-alanine, potassium, and coconut water—the evidence on file isn't established for the conditions listed, or insufficient data exists to rate them.

The evidence, ingredient by ingredient Sodium Potassium Betaine Anhydrous Glutamine Alpha-alanine Taurine Coconut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults, but people with kidney or liver disease should only use it under medical supervision. Common side effects include belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, headache, and musculoskeletal pain.

Two cases of mania or hypomania were reported in people with bipolar disorder taking high-dose glutamine. Sodium is well tolerated at normal dietary amounts but too much is linked to high blood pressure, worsening kidney disease, and cardiovascular strain.

Taurine is generally well tolerated short-term, with constipation, diarrhea, and indigestion as common side effects; rare cases of allergic reactions and hypersensitivity have been reported. Potassium at normal levels causes abdominal pain, belching, diarrhea, nausea, and vomiting, but high levels can cause dangerous heart rhythm problems and heart block.

Betaine anhydrous commonly causes body odor, diarrhea, nausea, and GI distress. Coconut may trigger allergic reactions ranging from hives to anaphylaxis in people sensitive to tree nuts or coconut.

Side effects, ingredient by ingredient Sodium Potassium Betaine Anhydrous Glutamine Alpha-alanine Taurine Coconut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Potassium, Glutamine, Taurine, Coconut, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; diabetes medications; lithium.
  • For scale: 355 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications if you take any of these: anticonvulsants (seizure drugs), blood pressure medications (especially ACE inhibitors, ARBs, and potassium-sparing diuretics), corticosteroids, lithium, HIV medications like didanosine, sodium phosphate bowel prep, tolvaptan, or diabetes medications. The sodium content is the biggest concern—it can make several of these drugs work less well or cause dangerous electrolyte imbalances.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a muscle-recovery amino acid blend aimed at athletes and people in training. If you take any blood pressure medication, heart drug, seizure medication, lithium, diabetes medication, or any potassium-related drug, check with your pharmacist before using it.

People with kidney disease, liver disease, or high blood pressure should talk to their doctor first. Stop and call your doctor if you notice chest pain, shortness of breath, severe nausea or vomiting, or any unusual symptoms after starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Build Next Gen Watermelon, straight from the product label.

Brand MuscleTech Performance Series
Barcode (UPC) 631656709193
Net contents 9.91 oz.; 281 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182483
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Build Next Gen Watermelon by MuscleTech Performance Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Gram(s)
Maximum serving Sizes:
20 Gram(s)
Servings per container
30
UPC/BARCODE
631656709193
IngredientAmount% DV
Calories25 Calorie(s), 50 Calorie(s)--
Total Carbohydrates1 Gram(s), 2 Gram(s)1%, 1%
L-Glutamine500 mg, 1 Gram(s)--
Sugar0 Gram(s), 0 Gram(s)--
Sodium70 mg, 140 mg3%, 6%
L-Alanine500 mg, 1 Gram(s)--
Taurine500 mg, 1 Gram(s)--
Sodium Chloride180 mg, 360 mg--
Dipotassium Phosphate40 mg, 80 mg--
Betaine Anhydrous1.25 Gram(s), 2.5 Gram(s)--
Potassium18 mg, 36 mg1%, 1%
Coconut Water50 mg, 100 mg--
L-Isoleucine, Micronized1 Gram(s), 2 Gram(s)--
L-Valine, Micronized1 Gram(s), 2 Gram(s)--
2:1:1 BCAA Matrix0 NP, 0 NP--
Strength-Enhancing Compound0 NP, 0 NP--
L-Leucine, Micronized2 Gram(s), 4 Gram(s)--
Cell-Volumizing and Recovery Complex0 NP, 0 NP--
Electrolyte Blend0 NP, 0 NP--
Watermelon50 mg, 100 mg--

Other ingredients: Malic Acid, Natural and Artificial flavors, Silicon Dioxide, Sucralose, Citric Acid, Salt, Calcium Silicate, Acesulfame-Potassium, FD&C Red No. 40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Clinically dosed, muscle- & performance-enhancing BCAA formula

Introducing Amino Build Next Gen – now with a new, advanced complex, featuring micronized BCAAs, clinically dosed Betaine and powerful cell volumizers, plus Coconut Water, Watermelon juice and new, delicious flavors.

Betaine has also been shown in a separate study to enhance muscle endurance.

Increase Strength by Over 40% Amino Build Next Gen is precisely formulated with a 4g dose of L-Leucine (in 2 scoops), shown in a clinical study to help subjects increase their 5-rep max strength by over 40%!

Enhances endurance performance with the first dose The 1g dose of Taurine found in 2 scoops of Amino Build Next Gen is clinically shown to improve performance in endurance athletes. And for a truly complete formula, precise doses of electrolytes were added to help replenish electrolyte stores that are depleted during your workout!

Clinically dosed BCAA formula

1g Carbs per scoop

Contains coconut ingredients.

Brand IP Statement(s)

MuscleTech researchers have taken their most powerful amino acid formula ever and made it even better.

Unlike inferior products that are underdosed with gimmicky amino acids and no studies to back up their claims, Amino Build Next Gen Energized is backed by 4 different clinical studies that demonstrate its muscle-, strength- and performance-enhancing abilities.

Amino Build Next Gen features researched doses of many key ingredients that make it better than regular BCAA formulas.

In fact, test subjects who supplemented with the exact dose of Betaine in 2 scoops of Amino Build Next Gen (2.5g) built 3.75 lbs. of lean muscle in 6 weeks compared to 0.66 lbs. by the placebo group.

2018. MuscleTech is America's #1 Selling Bodybuilding Supplement Brand based on cumulative wholesale dollar sales 2001 to present.

General Statements

Builds more muscle than regular BCAA formulas

That’s over 5.5 times the muscle gained (vs. the placebo).

Cholewa et al., 2013. Journal of the International Society of Sports Nutrition. 10(1): 39. Hoffman et al., 2009. Journal of the International Society of Sports Nutrition. 6:7. Muscle (lbs.) 4 3 2 1 0 Dose of betaine in Amino Build Next Gen 3.75 lbs. of muscle gained 0.66 lbs. of muscle gained Placebo

Ispoglou et al., 2011. International Journal of Sports Physiology and Performance. 6(1): 38-50.

Balshaw et al., 2013. Amino Acids. 44(2):555-561.

New formula, amazing taste! Research & Development America's #1 selling bodybuilding supplement brand

Builds more muscle than regular BCAAs Shown to boost strength by 40% First dose boost in endurance Results based on core ingredient testing. See back for study details. 30 Servings

Ingredients based on multiple clinical studies Natural & artificial flavors

Twitter @MuscleTech Instagram MuscleTech Like us on Facebook

Made in the U.S.A. from international ingredients.

Formulation

0 sugar

FDA Statement of Identity

Dietary Supplement

Precautions

Contains coconut ingredients. Processed in a facility that also processes egg, fish, milk, peanut, shellfish, soy, tree nut and wheat ingredients.

Warning: Not intended for use by persons under 18.

Do not use if you are pregnant or nursing.

Consult a medical doctor if you have a medical condition or before starting any diet or exercise program.

Keep out of reach of children.

Do not use if packaging has been tampered with.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop with 8 oz. of water. For full effects, mix 2 scoops with 16 oz. of water and consume pre- and intra-workout. Read the entire label before use and follow directions provided. If you want to add to your overall daily BCAA intake without the additional calories from drinking multiple protein shakes, you can also add 1 to 2 scoops to a jug of water and drink it over time.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General

14247US 0118

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino Build Next Gen Watermelon by MuscleTech Performance Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino Build Next Gen Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino Build Next Gen Watermelon by MuscleTech Performance Series

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Sodium

Interacts with
205 drugs
70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
18 mg per serving Form: Dipotassium Phosphate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

2:1:1 BCAA Matrix

0 NP per serving
  • › L-Isoleucine, Micronized
  • › L-Valine, Micronized
  • › L-Leucine, Micronized

Strength-Enhancing Compound

0 NP per serving

Cell-Volumizing and Recovery Complex

0 NP per serving

Electrolyte Blend

0 NP per serving

Other (inactive) ingredients: Malic Acid, Natural and Artificial flavors, Silicon Dioxide, Sucralose, Citric Acid, Salt, Calcium Silicate, Acesulfame-Potassium, FD&C Red No. 40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Build Next Gen Watermelon by MuscleTech Performance Series Drug Interactions

Want to check YOUR meds against Amino Build Next Gen Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
355Drugs
269 Moderate 86 Minor

Ingredients driving the most interactions

Sodium 205
Taurine 173
Coconut Water 86
Potassium 62
L-Glutamine 50

Individual Drug Interactions

The ingredients in Amino Build Next Gen Watermelon interact with 355 drugs. Click any drug to see the details.

5 of the 14 ingredients in Amino Build Next Gen Watermelon interact with drugs. Each result below shows which ingredient is responsible. Sodium Taurine Coconut Water Potassium L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Build Next Gen Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Coconut Water1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Water full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino Build Next Gen Watermelon, from the product label.

MuscleTech Performance Series

See all MuscleTech Performance Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Web Address
muscletech.com
Pharmacist Counseling Corner

Amino Build Next Gen Watermelon by MuscleTech Performance Series: Common Questions

Does Amino Build Next Gen Watermelon by MuscleTech Performance Series interact with any medications?
Yes. Based on its ingredients, Amino Build Next Gen Watermelon has a known interaction with 355 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Build Next Gen Watermelon contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use while pregnant or breastfeeding?
L-glutamine, L-alanine, taurine, potassium, and coconut water are rated likely safe in pregnancy. Sodium has one rating saying it's likely safe and another saying it's possibly unsafe in pregnancy, so talk with your doctor or pharmacist for personalized guidance. For breastfeeding, there isn't enough safety data on betaine anhydrous or on L-glutamine supplement doses, so check with your doctor before using it.
What are the most common side effects?
The most common side effects from the amino acids and electrolytes include belching, bloating, flatulence, constipation, diarrhea, nausea, vomiting, and headache. Betaine anhydrous can cause body odor. Most people tolerate the product fine, but GI upset is possible, especially at higher doses.
Can people with kidney disease or high blood pressure use this?
L-glutamine is not recommended for people with kidney or liver disease unless a doctor supervises it. The sodium and potassium in this formula make it risky for people with kidney disease or on blood pressure or heart medications. Talk to your doctor before using it if you have either condition.
Does this actually work for muscle building and recovery?
The amino acids in this product—glutamine, taurine, and the branched-chain amino acids—have some evidence for muscle recovery, especially after surgery or intense training. But the evidence on file isn't strong enough to say it will definitely help you build muscle. Results depend on your training, diet, and overall routine.
What if I'm allergic to coconut or tree nuts?
This product contains coconut water. If you have a coconut or tree nut allergy, avoid it—reactions can range from hives to severe anaphylaxis. Check the label for allergen warnings and talk to your doctor before use.
Can I use this if I take diabetes medication?
The coconut water in this product may theoretically increase insulin or lower blood sugar, posing a small risk of low blood sugar (hypoglycemia) if you take diabetes drugs. Check with your pharmacist before using it, especially if you're on insulin or other glucose-lowering medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino Build Next Gen Watermelon is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Build Next Gen Watermelon label
Go deeper

The Full Monographs Behind Amino Build Next Gen Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Alpha-alanine

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...

Read the full Alpha-alanine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph →
Sources

Sources & How We Checked

Amino Build Next Gen Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
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See these in context on the Sodium monograph →

Alpha-alanine 2 references
  1. Amino acids — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Alpha-alanine monograph →

Taurine 21 references
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  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
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  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
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  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
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  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

See these in context on the Taurine monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
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  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
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  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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