Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

ClearBalance Ingredients & Drug Interactions

by SeroVital

ClearBalance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ClearBalance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ClearBalance is a dietary supplement by SeroVital with 6 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 816 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine, Triticum aestivum Seed Extract, Myo-Inositol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ClearBalance by SeroVital

Ask about any prescription or over-the-counter medication and we check it for interactions with ClearBalance by SeroVital — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ClearBalance by SeroVital

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “ClearBalance Complex” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

ClearBalance contains six ingredients. The active ones are L-Theanine (an amino acid), Zinc (a mineral), Myo-Inositol (a naturally occurring compound), Hyaluronic Acid (a compound found in connective tissue), wheatgrass seed extract (Triticum aestivum), and melon fruit juice concentrate.

The product also contains inactive ingredients—fillers and binders like hydroxypropyl methylcellulose, rice flour, magnesium stearate, and silicon dioxide—that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Skin health, stress relief, and hormonal balance.
  • We looked for evidence on: Acne, Aging skin, Anxiety, Depression, Generalized anxiety disorder (GAD), Mood support — and 2 related terms.
  • The strongest evidence on file: Zinc is rated "Possibly Effective" for Acne (Natural Medicines).
  • Also on file: Inositol is rated "Possibly Ineffective" for Anxiety, Depression.
  • Also on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Postpartum depression.

The evidence for what this product does varies by ingredient. L-Theanine is possibly effective for cognitive function but we don't have reliable evidence yet for age-related cognitive decline, Alzheimer disease, or anxiety disorders.

Zinc is effective for zinc deficiency itself and likely effective for Wilson disease; it's possibly effective for acne, age-related eye disease (AMD), and diabetes. Myo-Inositol is possibly effective for polycystic ovary syndrome (PCOS) and metabolic syndrome but appears ineffective for anxiety and depression.

Hyaluronic acid is possibly effective for dry eye. For wheatgrass, the evidence we hold is insufficient to rate it against the conditions listed.

The data doesn't establish what ClearBalance as a whole product is meant to do or whether it's effective for that purpose.

The evidence, ingredient by ingredient Zinc Inositol Theanine Hyaluronic Acid Wheatgrass

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Theanine is generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. It may cause headaches, drowsiness, or vivid dreams.

Avoid it during pregnancy and breastfeeding—there isn't enough safety data. Zinc is well tolerated in recommended amounts (up to 40 mg daily for adults) but can cause nausea, diarrhea, metallic taste, and abdominal cramps, especially at higher doses.

High-dose zinc taken long-term risks copper deficiency. Zinc is likely safe in pregnancy and lactation at normal dietary amounts.

Myo-Inositol is generally well tolerated with mild digestive effects (gas, diarrhea, nausea); it's possibly safe in pregnancy but use only under medical supervision. Hyaluronic acid appears well tolerated orally, though long-term oral supplement safety isn't fully studied—avoid during pregnancy and breastfeeding without doctor approval.

Wheatgrass is generally well tolerated but may cause nausea, constipation, or allergic reactions; wheat allergies are common, so check if you're sensitive. There isn't enough pregnancy/breastfeeding safety data for wheatgrass.

We hold no safety data for melon fruit juice concentrate.

Side effects, ingredient by ingredient Zinc Inositol Theanine Hyaluronic Acid Wheatgrass

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Inositol, Zinc, Theanine, Wheatgrass.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 816 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ClearBalance, check with your pharmacist if you take blood pressure medications—L-Theanine may lower your pressure further. Antibiotics (quinolones, tetracyclines, cephalexin) and penicillamine require 2–6 hour spacing from zinc.

If you take HIV medications like ritonavir, integrase inhibitors, or Biktarvy, zinc may reduce their effectiveness. Antidiabetes drugs (including GLP-1 agonists, sulfonylureas, and metformin) may cause low blood sugar if combined with myo-inositol or wheatgrass.

Certain antidepressants and other serotonergic drugs theoretically interact with L-Theanine, though no clinical cases are reported. If you take cisplatin (a chemotherapy drug), discuss zinc supplementation with your oncologist.

Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ClearBalance is a multi-ingredient supplement that interacts with a substantial number of medications, especially antibiotics and HIV drugs (via zinc) and diabetes medications (via myo-inositol and wheatgrass). If you take any of those drug classes, or blood pressure or antidepressant medications, talk to your pharmacist or doctor before starting this product.

Most of the individual ingredients are generally well tolerated, but long-term safety data is limited, and pregnancy and breastfeeding are best discussed with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ClearBalance, straight from the product label.

Brand SeroVital
Barcode (UPC) 681168332044
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 265071
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ClearBalance by SeroVital, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
681168332044
IngredientAmount% DV
L-Theanine0 NP--
Zinc30 mg273%
Myo-Inositol2 Gram(s)--
Hyaluronic Acid0 NP--
ClearBalance Complex250 mg--
Triticum aestivum Seed Extract0 NP--
Melon Fruit Juice Concentrate0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Rice Flour, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Aging redefined Skin, stress, & hormone support Stress has a huge impact on the body and can lead to blemishes, dry, irritated akin, mental fatigue, and feeling unable to control the important aspects of your life. ClearBalance takes a multi-pronged, whole-self approach to reducing both outward and inward effects of stress. It's designed to help calm your body's response to stress, offering benefits that impact virtually every aspect of your life: Reducing stress-related breakouts Smoothing skin texture and improving fine lines Boosting mood Relieving stress Improving emotional well-being Supporting hormonal balance Enjoy a clearer complexion, improved mood, and younger, healthier-looking skin as you break the hold stress has on your life with ClearBalance. Clear Balance is designed to give you relief from many of the most frustrating effects of stress. It includes ingredients clinically validated to promote a clearer, more youthful complexion, balance excessive sebum production, support hormonal balance, reduce feelings of stress, and boost mood.

Reduces adult non-cystic acne Promotes a clearer, smoother complexion Supports hormonal balance Calms stress levels

Formula

Reduce blemishes with zinc Improve mood and relieve the impact of stress on the mind and body with l-theanine and SOD Increase skin hydration to reduce the feeling of dry, tight skin with ceramides Support hormonal balance with myo-inositol

General Statements

This box was desinged in an oversized manner to discourage pilferage. The actual size of the capsule is printed on the front of this box. Product resale allowed only through authorized representatives. International distribution is not authorized without prior written approval.

Discovery Innovation Science Research

1153892

Storage

Store at controlled room temperature: 15 degrees - 30 degrees C/59 degrees - 86 degrees F

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2021 All Rights Reserved

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take four (4) capsules together once daily, 20 minutes before breakfast.

Precautions

Contains: Wheat.

Warning: Do not exceed suggested daily serving.

Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult your physician before use if you are taking medication or have a medical condition.

Do not use if inner safety seal under the cap is broken or missing. Use only as directed.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ClearBalance by SeroVital label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ClearBalance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ClearBalance by SeroVital

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
30 mg per serving Form: Zinc Gluconate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Myo-Inositol

Interacts with
86 drugs
2 Gram(s) per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Myo-Inositol monograph & interactions

ClearBalance Complex

250 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice Flour, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

ClearBalance by SeroVital Drug Interactions

Want to check YOUR meds against ClearBalance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
816Drugs
501 Moderate 315 Minor

Ingredients driving the most interactions

L-Theanine 565
Triticum aestivum Seed Extract 272
Myo-Inositol 86
Zinc 67

Individual Drug Interactions

The ingredients in ClearBalance interact with 816 drugs. Click any drug to see the details.

4 of the 6 ingredients in ClearBalance interact with drugs. Each result below shows which ingredient is responsible. L-Theanine Triticum aestivum Seed Extract Myo-Inositol Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in ClearBalance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Triticum aestivum Seed Extract2 drug types · 272 drugs

Antidiabetes Drugs

Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Animal research shows that taking wheatgrass stimulates the release of insulin from beta-cells and lowers blood glucose.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that wheatgrass induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Triticum aestivum Seed Extract full monograph & interactions

Myo-Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Myo-Inositol full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ClearBalance, from the product label.

SeroVital

See all SeroVital products
Name
SeroVital, LLC
City
Salt Lake City
State
UT
ZipCode
84116
Phone Number
1-800-898-5153
Web Address
SeroVital.com
Pharmacist Counseling Corner

ClearBalance by SeroVital: Common Questions

Does ClearBalance by SeroVital interact with any medications?
Yes. Based on its ingredients, ClearBalance has a known interaction with 816 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ClearBalance contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-Theanine in ClearBalance supposed to do?
L-Theanine appears to possibly help with cognitive function, based on the research we have. The evidence for anxiety, Alzheimer disease, and other conditions isn't strong enough to rate yet.
Can I take ClearBalance if I'm pregnant?
Not enough safety data exists for most of these ingredients during pregnancy. L-Theanine, hyaluronic acid, and wheatgrass all advise against use without doctor approval; myo-inositol is possibly safe but only under medical supervision. Talk with your doctor or pharmacist before taking this product while pregnant.
Will ClearBalance lower my blood sugar?
Myo-Inositol and wheatgrass both lower blood glucose in research, so if you take diabetes medications, there's a risk of blood sugar dropping too low. Always check with your pharmacist before adding this to a diabetes regimen.
Are there common side effects I should expect?
L-Theanine may cause headaches or drowsiness. Zinc can cause nausea, diarrhea, metallic taste, and stomach cramps, especially at higher doses. Myo-Inositol may cause gas, diarrhea, or nausea. Wheatgrass may cause nausea or constipation.
Does ClearBalance contain any allergens?
Wheatgrass is a wheat product, and wheat is a major food allergen. If you have a wheat allergy, avoid this product. We hold no data on whether melon fruit juice concentrate triggers allergies.
What are the inactive ingredients?
The capsule is made with hydroxypropyl methylcellulose, rice flour, magnesium stearate, and silicon dioxide—all common fillers and binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ClearBalance label
Go deeper

The Full Monographs Behind ClearBalance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Wheatgrass

Interacts with 272 drugs

Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most...

Read the full Wheatgrass monograph →
Sources

Sources & How We Checked

ClearBalance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 117 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
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Inositol 14 references
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Hyaluronic Acid 4 references
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Wheatgrass 5 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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