Wheatgrass - Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Interaction
Herbal: Wheatgrass
Also Known As: Triticum aestivum, Agropyre, Blé en Herbe, Bread Wheat, Brote del Trigo, Common Wheat, Grano, Herbe de Blé, Wheat, Wheat Grass
Drug: Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
Brand names:
Conar-A
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine is classified as belonging to the following category: Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that wheatgrass induces CYP1A2 enzymes.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022.
Wheatgrass Overview
Wheatgrass is a type of grass that is typically grown from the wheat plant (Triticum aestivum). It is often consumed in the form of juice or powder.
Wheatgrass is a good source of vitamins, minerals, and amino acids, and it is believed to have antioxidant and anti-inflammatory properties. It is often used as a supplement to help improve digestion, boost the immune system, improve energy levels, promote weight loss, and reduce the symptoms of conditions such as arthritis and asthma.
For most individuals, supplementation with wheatgrass is primarily used as a concentrated source of nutrients as the powdered form can easily be added to health drinks.
Wheatgrass - More Interactions
Wheatgrass interacts with 269 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist