Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Clen-Extreme OTC Ingredients & Drug Interactions

by Tokkyo Nutrition

Clen-Extreme OTC label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clen-Extreme OTC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Clen-Extreme OTC is a dietary supplement by Tokkyo Nutrition with 4 active ingredients. Its ingredients are commonly taken for mood support, focus and concentration, energy and pre-workout boost.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selective Alpha-2 Antagonist Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Clen-Extreme OTC by Tokkyo Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Clen-Extreme OTC by Tokkyo Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Clen-Extreme OTC by Tokkyo Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 4 active ingredients.

Clen-Extreme OTC contains 4 ingredients listed on the label. One is identified as phenethylamine (PEA), a compound that works on brain chemicals involved in mood and energy.

The other three — Proprietary Weight Loss Formulation, Expherdrine HCL, and Adrenaline Sensitizing Complex — are not individually listed by name in our data, so we can't tell you their specific roles. The product also contains inactive ingredients (gelatin, maltodextrose, rice powder, magnesium stearate, silica, and cellulose) that serve as fillers and binders in the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Phenethylamine (pea)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: fat burning and weight loss support.
  • We looked for evidence on: Obesity, weight management, metabolic rate, body composition.
  • The closest evidence on file: Phenethylamine (pea) is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence we hold does not establish that phenethylamine works for athletic performance, depression, or weight loss — the ratings are insufficient to support any of those uses. We have no effectiveness data on file for the other three active ingredients.

The evidence, ingredient by ingredient Phenethylamine (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phenethylamine may affect your heart rate and blood pressure, and human safety data for supplements is limited. A small number of case reports describe anxiety, agitation, and rapid heart rate in people taking weight loss products containing phenethylamine along with other stimulants, though it's unclear which ingredient was responsible.

There isn't enough safety data to know whether this product is safe in pregnancy or while breastfeeding — the safety data advises against use in both. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Phenethylamine (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenethylamine (pea).
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take serotonergic drugs — that includes most antidepressants, anti-anxiety medications, and migraine drugs — or if you take an MAOI. We cannot check the three other active ingredients, so your pharmacist may identify additional concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take an antidepressant, anti-anxiety medication, or an older antidepressant called an MAOI, you need to check this product with your pharmacist before starting. We also can't check three of the four ingredients for safety, so bring your full medication list and medical history to the conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clen-Extreme OTC, straight from the product label.

Brand Tokkyo Nutrition
Barcode (UPC) 896896002118
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19865
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clen-Extreme OTC by Tokkyo Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
896896002118
IngredientAmount% DV
Proprietary Weight Loss Formulation0 NP--
Expherdrine HCL(TM)200 mg--
Adrenaline Sensitizing Complex50 mg--
Selective Alpha-2 Antagonist Complex30 mg--

Other ingredients: Gelatin, Maltodextrose, Rice powder, Magnesium Stearate, Silica, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Tokkyo Nutrition presents the newest addition to their hardcore diet line, Clen-Extreme.

Prescription Potency Fat Burner Inhibits Receptor Downgrade Effectively Blocks Alpha-2 Receptors {Molecular Drawing}

Extensive Japanese research has determined Clen-Extreme to be the strongest fat burner on the market. Clen-Extreme inhibits receptor downgrade and blocks alpha-2 receptors, making it work longer and stronger. Start seeing results today.

Formula

Clen-Extreme contains a new advanced complex of 200mg of Exphedrine HCL(TM)

Storage

Store in a cool, dry place away from sunlight. Always keep tightly sealed.

Precautions

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history or any indication of, high blood pressure, heart disease, cardiac arrhythmias, liver, kidney, thyroid, or psychiatric disease, psychosis, bipolar disorder, phenochromacytoma, diabetes, asthma, recurrent headaches, anemia, nervousness, anxiety, depression, or other psychiatric condition, peptic ulcers, Parkinson's disease, glaucoma, difficulty urinating, prostate enlargement, or seizure disorder, or if you are using a monoamine oxidase inhibitor (MAOI) (anti-depressant) or any other dietary supplement, or prescription drug.

Allergy Warning: Manufactured in a facility that processes milk, soy and egg proteins, nuts, and other tree nuts and wheat.

READ ALL LABEL INFORMATION AND WARNINGS. DO NOT EXCEED RECOMMENDED DOSAGE.

Keep out of reach of children.

WARNING: MUST BE 18 YEARS OR OLDER TO PURCHASE.

DO NOT USE IF PREGNANT OR NURSING.

Brand IP Statement(s)

Do not exceed recommended serving as this may cause serious adverse health effects, including heart attack and stroke. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms. Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine with this product may experience serious adverse health affects, Individuals who are sensitive to the affects of caffeine should not use this product. Do not use during extended strenuous exercise activity lasting longer then 30 minutes especially in high temperature or humid conditions (greater than 80 degrees fahrenheit).

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement take two (2) capsules in the morning and two (2) capsules in the afternoon with a meal. Drink at least 6 to 8 glasses of water daily while using this supplement.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clen-Extreme OTC by Tokkyo Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clen-Extreme OTC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clen-Extreme OTC by Tokkyo Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Weight Loss Formulation

0 NP per serving

Expherdrine HCL(TM)

200 mg per serving Form: Caffeine, Guarana, Guggulsterone, Magnesium Salicylate, Synephrine, Theobromine

Adrenaline Sensitizing Complex

50 mg per serving Form: L-Tyrosine, Licorice

Selective Alpha-2 Antagonist Complex

Interacts with
187 drugs
30 mg per serving Form: Phenylethylamine

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. R...

Selective Alpha-2 Antagonist Complex monograph & interactions

Other (inactive) ingredients: Gelatin, Maltodextrose, Rice powder, Magnesium Stearate, Silica, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Clen-Extreme OTC by Tokkyo Nutrition Drug Interactions

Want to check YOUR meds against Clen-Extreme OTC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Selective Alpha-2 Antagonist Complex 187

Individual Drug Interactions

The ingredients in Clen-Extreme OTC interact with 187 drugs. Click any drug to see the details.

1 of the 4 ingredients in Clen-Extreme OTC interact with drugs. Each result below shows which ingredient is responsible. Selective Alpha-2 Antagonist Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Clen-Extreme OTC with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Selective Alpha-2 Antagonist Complex2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
Selective Alpha-2 Antagonist Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clen-Extreme OTC, from the product label.

Tokkyo Nutrition

See all Tokkyo Nutrition products
Name
FPL Wholesalers LLC.
Street Address
P.O. Box 10696
City
Bedford
State
NH
ZipCode
03110
Phone Number
1-866-320-0141
Web Address
www.tokkyonutrition.com
Pharmacist Counseling Corner

Clen-Extreme OTC by Tokkyo Nutrition: Common Questions

Does Clen-Extreme OTC by Tokkyo Nutrition interact with any medications?
Yes. Based on its ingredients, Clen-Extreme OTC has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clen-Extreme OTC contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with weight loss?
The evidence we hold doesn't establish that phenethylamine works for weight loss. We have no effectiveness data on the other three active ingredients either.
Can I take this while I'm on an antidepressant?
That depends on which antidepressant you take. Phenethylamine in this product carries a Moderate interaction risk with serotonergic drugs, which includes most antidepressants. Talk to your pharmacist before starting — they can tell you whether your specific medication is a concern.
Is it safe if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way. The safety data advises against use in both pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
Phenethylamine may affect your heart rate and blood pressure. A small number of people taking weight loss products containing phenethylamine along with other stimulants have reported anxiety, agitation, and rapid heart rate, though it's not clear which ingredient caused those effects.
What does phenethylamine actually do?
Phenethylamine works on brain chemicals involved in mood and energy. Animal research shows it increases levels of serotonin, norepinephrine, and dopamine — neurotransmitters that affect how you feel and your overall energy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Clen-Extreme OTC is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clen-Extreme OTC label
Go deeper

The Full Monographs Behind Clen-Extreme OTC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph →
Sources

Sources & How We Checked

Clen-Extreme OTC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenethylamine (pea) 9 references
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

See these in context on the Phenethylamine (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team