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Dietary supplement

Codonopsis Extract 2,000 mg Alcohol-Free Ingredients & Drug Interactions

by Nature's Answer

Codonopsis Extract 2,000 mg Alcohol-Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Codonopsis Extract 2,000 mg Alcohol-Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Codonopsis Extract 2,000 mg Alcohol-Free is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, digestive support and poor appetite, immune support.Based on those ingredients, 211 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Codonopsis Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Codonopsis Root Extract at 2,000 mg per dose. Codonopsis is a plant root used in traditional medicine.

The liquid formula also includes glycerin and purified water as inactive ingredients—no alcohol despite being a liquid extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Codonopsis product and its label doesn't state a use — see Codonopsis's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting codonopsis for the conditions listed—asthma, cancer, respiratory infections, indigestion, and high cholesterol—is insufficient to establish whether it works. We don't have enough reliable data on file to rate it for any of these uses.

The evidence, ingredient by ingredient Codonopsis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Codonopsis is generally well tolerated in traditional food-like amounts, though high-quality safety data are limited. Very large doses (30–60 grams) may cause chest pain, irregular heartbeat, throat pain, or loss of voice.

Allergic reactions including anaphylaxis and skin rash (urticaria) have been reported, even at moderate doses in sensitive individuals. During pregnancy, the safety data advises against use.

While breastfeeding, there isn't enough information to know whether it's safe, so avoid it unless your doctor advises otherwise.

Side effects, ingredient by ingredient Codonopsis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Codonopsis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 211 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before starting if you take blood thinners or antiplatelet drugs (Moderate severity), diabetes medications (Moderate severity), or abiraterone (Zytiga) for cancer (Moderate severity). All three types of medications may be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Codonopsis is a traditional plant extract that you may encounter for various respiratory and digestive claims, but the evidence isn't established for those uses. It's worth avoiding if you take blood thinners, diabetes drugs, or abiraterone without talking to your pharmacist first.

If you're pregnant or nursing, skip it unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Codonopsis Extract 2,000 mg Alcohol-Free, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000007224
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 326720
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000007224
IngredientAmount% DV
Calories5 Calorie(s)--
Codonopsis Root Extract1000 mg--
Total Carbohydrates1 Gram(s)1%

Other ingredients: Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

Gluten-free Alcohol-free Absolutely no preservatives

Our alcohol-free extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Seals/Symbols

K Parve (Kosher)

Formula

K Parve (Kosher)

Bio-Chelated Cold Extract process Codonopsis pilasula Made from 2,000 mg Codnopsis Root per serving

Brand IP Statement(s)

Nature's Answer Since 1972 Discover Nature's Answer

Copyright 2019 Nature's Answer

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary Supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

General Statements

For product information, call (800)439-2324

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Codonopsis Extract 2,000 mg Alcohol-Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Codonopsis Root Extract

Interacts with
211 drugs
1000 mg per serving Form: Codonopsis pilosula Root Extract

Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently as a mild...

Codonopsis Root Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer Drug Interactions

Want to check YOUR meds against Codonopsis Extract 2,000 mg Alcohol-Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
211Drugs
211 Moderate

Ingredients driving the most interactions

Codonopsis Root Extract 211

Individual Drug Interactions

The ingredients in Codonopsis Extract 2,000 mg Alcohol-Free interact with 211 drugs. Click any drug to see the details.

1 of the 1 ingredient in Codonopsis Extract 2,000 mg Alcohol-Free interact with drugs. Each result below shows which ingredient is responsible. Codonopsis Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Codonopsis Extract 2,000 mg Alcohol-Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Codonopsis Root Extract3 drug types · 211 drugs

Abiraterone (Zytiga)

Theoretically, taking codonopsis root with abiraterone might reduce the levels and therapeutic effects of abiraterone.
Animal research in rats shows that intragastric administration of codonopsis root along with abiraterone every 2 days for 2 weeks seems to increase the clearance of abiraterone and reduce the overall exposure and time to maximum concentration. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, codonopsis liquor might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
A small clinical study in adults with coronary heart disease shows that consuming Codonopsis pilosula liquor for 4 weeks inhibits platelet aggregation but does not affect tissue-type plasminogen activator (t-PA) or plasminogen activator inhibitor (PAI).

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Laboratory and animal research suggest that codonopsis has antidiabetic effects.

Likelihood Possible Evidence D
Codonopsis Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Codonopsis Extract 2,000 mg Alcohol-Free, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer: Common Questions

Does Codonopsis Extract 2,000 mg Alcohol-Free by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Codonopsis Extract 2,000 mg Alcohol-Free has a known interaction with 211 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Codonopsis Extract 2,000 mg Alcohol-Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No—the safety data advises against codonopsis during pregnancy. Talk with your doctor or pharmacist about whether you should use it.
Is it safe while breastfeeding?
Safety while breastfeeding is unknown, so avoid it unless your doctor advises otherwise. There isn't enough data to know either way.
What are the side effects?
At normal doses, codonopsis is generally well tolerated. Very large doses (30–60 grams) may cause chest pain, irregular heartbeat, throat pain, or loss of voice. Allergic reactions including anaphylaxis and rash have been reported in sensitive people, even at moderate doses.
Does codonopsis actually work for asthma or colds?
The evidence for codonopsis in asthma, respiratory infections, indigestion, high cholesterol, or cancer is insufficient—we don't have reliable data to say whether it works for any of these.
What is codonopsis used for?
Codonopsis is a plant root used in traditional medicine, but the claims made for it—asthma, cancer, colds, indigestion, and high cholesterol—lack solid evidence in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Codonopsis Extract 2,000 mg Alcohol-Free is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Codonopsis Extract 2,000 mg Alcohol-Free label
Go deeper

The Full Monographs Behind Codonopsis Extract 2,000 mg Alcohol-Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Codonopsis

Interacts with 211 drugs

Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently as a milder substitute for ginseng. Human researc...

Read the full Codonopsis monograph →
Sources

Sources & How We Checked

Codonopsis Extract 2,000 mg Alcohol-Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Codonopsis 5 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Xu, X., Wang, S. R., and Lin, Q. [Clinical and experimental study on codonopsis pilosula oral liquor in treating coronary heart disease with blood stasis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(7):398-400.
  3. Hur GY, Choi GS, Park HJ, Ye YM, Park HS. Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis. Allergy. 2008;63(10):1406-7.
  4. Zhang ZB, Ip SP, Cho WCS, et al. Herb-drug interactions between androgenic Chinese herbal medicines and androgen receptor antagonist on tumor growth: Studies on two xenograft prostate cancer animal models. Phytother Res. 2021.
  5. Jia W, Bi Q, Jiang S, et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS. Food Funct 2022;13(5):2456-2464.

See these in context on the Codonopsis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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