CLA Ingredients & Drug Interactions
by OL Olympian Labs Performance Sports Nutrition
What is this page for?
First and foremost: checking CLA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CLA is a dietary supplement by OL Olympian Labs Performance Sports Nutrition with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, skin moisturizing, menstrual cramps.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil Concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CLA by OL Olympian Labs Performance Sports Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with CLA by OL Olympian Labs Performance Sports Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of CLA by OL Olympian Labs Performance Sports Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 5 active ingredients, all of them fatty acids or fatty acid concentrates. The main active is Conjugated Linoleic Acid (CLA), a fatty acid found naturally in meat and dairy; the formula also includes Oleic Acid (the heart-healthy fat in olive oil), Linoleic Acid, Palmitic Acid, and Safflower Oil Concentrate as a delivery source.
The softgel capsule itself is made from gelatin, glycerin, water, caramel, and carob — these are inactive fillers and binders.
Does it work?
Not established
Oleic acid, one of the active ingredients here, is rated Possibly Effective for lowering cholesterol and for heart disease risk. The evidence base we hold doesn't establish ratings for the other active ingredients in this formula, including Conjugated Linoleic Acid itself, so we can't tell you from our data whether CLA lives up to its workout or body-composition claims.
Talk with your pharmacist about what the current research says for your specific goal.
How safe is it?
Some data gaps
Oleic acid from food sources — like olive oil — is generally recognized as safe in normal amounts. When it comes to concentrated supplement doses during pregnancy or while breastfeeding, the safety data we hold isn't robust enough to say either way.
If you're pregnant, nursing, or planning to become pregnant, chat with your doctor or pharmacist about whether this product is right for you. No adverse effects are documented in our data for the ingredients we reviewed.
Meds to double-check
Moderate interaction found
If you take antidiabetes drugs — oral medications that lower blood sugar — double-check them in our interaction checker before using CLA. The oleic acid in this product may increase their effect, which could lower your blood sugar more than intended.
No other medication interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.
CLA may interest athletes and fitness enthusiasts looking to support body composition. If you take diabetes medications, check your specific drugs with our tool before you start — oleic acid can strengthen their blood-sugar-lowering effect.
Pregnant or nursing? Talk with your pharmacist first, since concentrated doses of these fatty acids haven't been well studied in those settings.
For personalized guidance, your pharmacist is the best resource.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CLA, straight from the product label.
| Brand | OL Olympian Labs Performance Sports Nutrition |
|---|---|
| Barcode (UPC) | 710013031150 |
| Net contents | 210 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 326653 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CLA by OL Olympian Labs Performance Sports Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 Calorie(s) | -- |
| Stearic Acid | 0 NP | -- |
| Calories from Fat | 27 Calorie(s) | -- |
| Total Fat | 3 Gram(s) | 5% |
| Conjugated Linoleic Acid | 0 NP | -- |
| Oleic Acid | 0 NP | -- |
| Palmitic Acid | 0 NP | -- |
| Linoleic Acid | 0 NP | -- |
| Safflower Oil Concentrate | 3 Gram(s) | -- |
Other ingredients: Gelatin, Glycerin, Water, Caramel, Carob
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
CLA (Conjugated Linoleic Acid) is a targeted, stimulant free solution to help maximize your fitness efforts, reduce body fat and increase lean muscle mass. Studies suggest CLA works by increasing your metabolic rate to help burn calories and pushing glucose (blood sugar) into muscle cells instead of letting it turn into body fat. CLA, when used in conjunction with a regimented diet and exercise plan, helps you get the muscle tone you want. CLA can also be stacked with additional weight management products.
CLA 3000mg per serving
Formulation
Olypian Labs, Inc. products are made with the highest quality ingredients and manufactured according to current Good Manufacturing Practices (cGMP).
Gluten Free Allergen Free Non GMO We do not use ingredients that were produced using modern biotechnology
May help reduce body fat Supports lean muscle mass May increase metabolic rate Muscle growth Fat burner
Made in USA
Precautions
Caution: If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any other nutritional supplement.
Discontinue use if allergic reaction occurs.
Keep out of reach of children.
Prop 65 Warning for California residents Warning: This product can expose you to chemicals, including lead, cadmium, arsenic, and mercury, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Store in a cool, dry place.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Daily Suggested use: As a dietary Supplement, take three (3) softgels daily, or as directed by a healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CLA by OL Olympian Labs Performance Sports Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CLA by OL Olympian Labs Performance Sports Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container70 Amounts shown are per serving.
Safflower Oil Concentrate
Interacts with208 drugs
Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...
Safflower Oil Concentrate monograph & interactions- › Stearic Acid
- › Conjugated Linoleic Acid
- › Oleic Acid
- › Palmitic Acid
- › Linoleic Acid
Other (inactive) ingredients: Gelatin, Glycerin, Water, Caramel, Carob. These complete the product’s ingredient list but are not active constituents.
CLA by OL Olympian Labs Performance Sports Nutrition Drug Interactions
HelloPharmacist Interaction Report
OL Olympian Labs Performance Sports Nutrition CLA does interact with one class of medication we've documented.
Oleic acid, one of the active ingredients, may increase the effects of antidiabetes drugs (blood sugar–lowering medications). Early research in people with type 2 diabetes shows that a diet rich in oleic acid from olive oil can lower fasting blood sugar levels compared to a diet higher in linoleic acid.
This is a Moderate-severity interaction, meaning your blood sugar could drop lower than expected if you're taking oral diabetes medications alongside this product.
Read the full breakdown — every affected drug type, severity by severity
We were unable to check three other active ingredients in this formula — Stearic Acid, Conjugated Linoleic Acid, Palmitic Acid, and Linoleic Acid — because we hold no interaction data for them. That doesn't mean they don't interact; it means we simply haven't reviewed them.
Altogether, these interactions span 85 individual medications.
If you take diabetes medications, run your exact drugs through our interaction checker below before starting CLA. Your pharmacist or doctor can help you decide if monitoring is needed.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CLA?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CLA interact with 208 drugs. Click any drug to see the details.
1 of the 1 ingredient in CLA interact with drugs. Each result below shows which ingredient is responsible. Safflower Oil Concentrate
AbciximabReoPro
How Abciximab interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Acarbose interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Acetohexamide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Albiglutide interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin interactionSafflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Alogliptin, Metformin interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Pioglitazone interactionSafflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with CLA — through 2 ingredients. Tap an ingredient for the detail:
Safflower Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full Safflower Oil Concentrate + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with CLA — through 1 ingredient. Tap an ingredient for the detail:
Safflower Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Safflower Oil Concentrate + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CLA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Safflower Oil Concentrate
Anticoagulant/Antiplatelet Drugs
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Antidiabetes Drugs
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.
Warfarin
Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Brand information
Manufacturer and brand details for CLA, from the product label.
OL Olympian Labs Performance Sports Nutrition
See all OL Olympian Labs Performance Sports Nutrition products- Name
- Olympian Labs, Inc.
- City
- Phoenix
- State
- AZ
- ZipCode
- 85027
- Phone Number
- 1-800-473-5883
- Web Address
- www.olympianlabs.com
CLA by OL Olympian Labs Performance Sports Nutrition: Common Questions
Does CLA by OL Olympian Labs Performance Sports Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does CLA really help with body composition or fat loss?
Is this safe if I'm pregnant or breastfeeding?
What's in this capsule besides the active ingredients?
I take metformin for type 2 diabetes. Can I use this?
Are there any side effects from this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CLA is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CLA’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Safflower
Interacts with 208 drugsSafflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...
Read the full Safflower monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
CLA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
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