Constipation Formula Powder Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Constipation Formula Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Constipation Formula Powder is a dietary supplement by TerraVita Premium Collection with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 790 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boldo, Powder, Artichoke powder, Black Radish powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Constipation Formula Powder by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Constipation Formula Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Constipation Formula Powder by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This powder contains three active ingredients. Artichoke powder, boldo powder, and black radish powder make up the formula — no other active ingredients are listed.
These are the only components shown; there are no inactive fillers or binding agents on file for this product.
Does it work?
Not established
The evidence for what this formula actually does is mixed. Artichoke is rated possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia), but we don't have enough data to rate it for fatty liver disease.
Boldo and black radish are both rated as having insufficient evidence — meaning we don't know if they work for the conditions they're traditionally used for, including bile and gallbladder concerns and blood sugar control. For constipation specifically, the product name suggests that's its purpose, but none of the three ingredients carry an effectiveness rating for constipation in the data we hold.
How safe is it?
Well-documented data
Artichoke is generally well tolerated as a food and short-term supplement, though it can cause abdominal pain, diarrhea, gas, hunger, and nausea in some people. Rarely, people sensitive to inulin (a fiber in artichoke) have had anaphylaxis.
If you're allergic to ragweed, chrysanthemums, daisies, or other plants in that family, you may react to artichoke. Boldo poses more caution: the ascaridole it contains is a liver toxin, and cases of hepatotoxicity — elevated liver enzymes and jaundice — have been reported.
Common side effects include abdominal pain, nausea, and vomiting. Black radish is safe in normal food amounts but may cause mild indigestion or throat tightness in rare cases.
Pregnancy: the safety data advises against artichoke and boldo in supplement form during pregnancy (boldo is thought to stimulate the uterus). Breastfeeding: safety hasn't been established for artichoke or boldo, so they're best avoided; radish safety during breastfeeding is not well studied in concentrated supplement form.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take blood thinners like warfarin (Moderate risk of increased bleeding), any blood pressure medication (Moderate risk of too-low pressure from artichoke), diabetes drugs (Moderate risk of low blood sugar from artichoke and black radish), lithium (Moderate risk of raised lithium levels from boldo), tacrolimus or other transplant drugs (Moderate risk of reduced drug levels from boldo), or any drugs that can harm the liver (Moderate risk of liver injury from boldo).
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This formula combines three ingredients with limited proven effectiveness for constipation and moderate interactions with several medication types — most notably blood thinners, blood pressure drugs, diabetes medications, lithium, and transplant drugs like tacrolimus. The boldo ingredient carries a particular hepatotoxicity risk.
If you take any prescription medications, especially for heart, blood pressure, diabetes, mood, or transplant issues, talk with your doctor or pharmacist before starting this product to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Constipation Formula Powder, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435121389 |
| Net contents | 1 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 285087 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Constipation Formula Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1000 mg | -- |
| Artichoke powder | 0 NP | -- |
| Boldo, Powder | 0 NP | -- |
| Black Radish powder | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Formula
Artichoke, black radish and boldo
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Constipation Formula Powder by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Constipation Formula Powder by TerraVita Premium Collection
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container28 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Constipation Formula Powder by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
TerraVita Premium Collection Constipation Formula Powder contains three active ingredients, two of which have documented interactions with medications.
The most serious concern is boldo powder, which can increase the risk of bleeding when combined with blood thinners (anticoagulant and antiplatelet drugs) like warfarin — a Moderate severity interaction backed by a case report. Boldo also carries a Moderate risk with drugs that harm the liver (hepatotoxic drugs), since boldo itself contains ascaridole, a known liver toxin, and multiple cases of elevated liver enzymes have been reported with its use.
Read the full breakdown — every affected drug type, severity by severity
Additionally, boldo interacts with lithium (a mood stabilizer), potentially raising its levels and effects, and with tacrolimus (an immunosuppressant used after transplant), which may reduce tacrolimus levels and increase transplant rejection risk — both Moderate severity. Artichoke powder poses Moderate interactions with blood pressure medications (antihypertensive drugs), diabetes medications (antidiabetes drugs), and certain drugs processed through liver pathways (CYP2C19 and CYP2B6 substrates).
Black radish powder has a Moderate interaction with antidiabetes drugs, raising the theoretical risk of low blood sugar (hypoglycemia).
We could not check the proprietary blend's components beyond the three named ingredients listed. Altogether, these interactions span 791 individual medications.
Please check your exact medications with the tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Constipation Formula Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Constipation Formula Powder interact with 790 drugs. Click any drug to see the details.
3 of the 3 ingredients in Constipation Formula Powder interact with drugs. Each result below shows which ingredient is responsible. Boldo, Powder Artichoke powder Black Radish powder
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo, Powder + Abciximab interactionAbiraterone
How Abiraterone interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Constipation Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Artichoke PowderCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Powder + Abrocitinib interactionBoldo, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo, Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Constipation Formula Powder — through 3 ingredients. Tap an ingredient for the detail:
Black Radish PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Black Radish Powder + Acarbose interactionBoldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acarbose interactionArtichoke PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Constipation Formula Powder — through 2 ingredients. Tap an ingredient for the detail:
Artichoke PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Powder + Acebutolol interactionBoldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo, Powder + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo, Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Constipation Formula Powder — through 1 ingredient. Tap an ingredient for the detail:
Boldo, PowderHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Constipation Formula Powder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Boldo, Powder
Anticoagulant/Antiplatelet Drugs
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.
Hepatotoxic Drugs
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.
Lithium
Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.
Tacrolimus (Prograf)
Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.
Warfarin (Coumadin)
A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.
Artichoke powder
Antidiabetes Drugs
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.
Antihypertensive Drugs
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.
Black Radish powder
Antidiabetes Drugs
Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that radish extract, juice, and sprouts can reduce glucose levels. Animal research also shows that radish root juice 300 mg/kg reduces fasting and postprandial blood glucose in a rat model of diabetes, with effects similar to glibenclamide.
Brand information
Manufacturer and brand details for Constipation Formula Powder, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Constipation Formula Powder by TerraVita Premium Collection: Common Questions
Does Constipation Formula Powder by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is boldo, and why is it in a constipation formula?
Can I take this if I'm on warfarin or another blood thinner?
Is artichoke safe if I have high blood pressure or take blood pressure medication?
Can I take this during pregnancy?
What side effects might I experience?
Will this work for my constipation?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Constipation Formula Powder is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Constipation Formula Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Artichoke
Interacts with 363 drugsArtichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...
Read the full Artichoke monograph → Herb & supplement monographBoldo
Interacts with 482 drugsBoldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...
Read the full Boldo monograph → Herb & supplement monographRadish
Interacts with 86 drugsRadish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver suppo...
Read the full Radish monograph →Sources & How We Checked
Constipation Formula Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Artichoke 16 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
- Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
- Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
- Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
- Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
- Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
- Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
- Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
- Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
- Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
- Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
- Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
- Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
- Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
- Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed
Boldo 10 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
- Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
- Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
- Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
- Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
- Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed
Radish 5 references
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
- Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
- Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
- Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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