No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Crampbark Ingredients & Drug Interactions

by Pure Herbs

Crampbark label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Crampbark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Crampbark is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for menstrual cramps, muscle spasms, general cramping pain.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Crampbark by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: crampbark bark extract. Crampbark has been used in traditional herbal medicine, though modern human safety and effectiveness data are limited.

The product contains no other inactive ingredients or fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cramp Bark's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: alleviate cramping during menstruation.
  • We looked for evidence on: Dysmenorrhea, menstrual pain, period cramps.
  • The closest evidence on file: Cramp Bark is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea (Natural Medicines).

The effectiveness data we hold shows insufficient evidence to rate crampbark for any of its traditional uses — muscle cramps, dysmenorrhea (painful menstrual periods), pregnancy-related leg cramps, kidney stones, and diabetes. That doesn't mean it doesn't work; it means the clinical evidence isn't established in the sources we have on file.

The evidence, ingredient by ingredient Cramp Bark

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Crampbark is generally used in traditional medicine, but human safety data are limited. Trial side effects are not documented in our data.

Safety during pregnancy is not established, so it's best avoided if you're pregnant. There isn't enough safety information for breastfeeding either.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Cramp Bark

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for crampbark. Even so, mention this supplement to your doctor or pharmacist if you take any medications, and run your exact drugs through the checker on this page to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and some safety-information gaps remain.

Crampbark by Pure Herbs is a single-ingredient liquid used traditionally for muscle and menstrual cramps, though modern evidence for how well it works is not yet established. If you're pregnant or breastfeeding, the safety data advise against it — check with your doctor or pharmacist first.

Even though no drug interactions are documented, it's always worth confirming with your own healthcare provider before you start any new supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Crampbark, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278768
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Girls: (All), Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Crampbark by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Crampbark Bark Extract1977 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Promotes the maintenance of good health. Helps to alleviate cramping during menstruation and supports a healthy menstruation.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Crampbark by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Crampbark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Crampbark by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Crampbark Bark Extract

No known
interactions
1977 mg per serving

Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very l...

Crampbark Bark Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Crampbark by Pure Herbs Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Crampbark. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Crampbark, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Crampbark by Pure Herbs: Common Questions

Does Crampbark by Pure Herbs interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Crampbark. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Crampbark contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Safety during pregnancy is not established, so crampbark is best avoided. Talk with your doctor or pharmacist about whether it's right for you in pregnancy.
Is it safe while breastfeeding?
There isn't enough safety information for breastfeeding. Speak with your doctor or pharmacist before using it.
Does crampbark actually work for muscle cramps?
Crampbark has been used in traditional medicine for muscle cramps, but the modern clinical evidence isn't established in our data — we can't rate how well it works based on what we have on file.
What are the side effects?
Adverse effects are not documented in our data. Because human safety data are limited overall, stop and speak with your doctor or pharmacist if you notice any unusual symptoms after you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Crampbark is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Crampbark label
Go deeper

The Full Monographs Behind Crampbark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cramp Bark

Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well...

Read the full Cramp Bark monograph →
Sources

Sources & How We Checked

Crampbark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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