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Dietary supplement

Cranberry Gummies Cran-Raspberry Flavored Ingredients & Drug Interactions

by Sundown

Cranberry Gummies Cran-Raspberry Flavored label
See full label image
Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cranberry Gummies Cran-Raspberry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cranberry Gummies Cran-Raspberry Flavored is a dietary supplement by Sundown with 2 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 862 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pacran Cranberry concentrate powder, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cranberry Gummies Cran-Raspberry Flavored by Sundown

Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry Gummies Cran-Raspberry Flavored by Sundown — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cranberry Gummies Cran-Raspberry Flavored by Sundown

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

These gummies contain 2 active ingredients: sodium and Pacran cranberry concentrate powder. Sodium is an electrolyte essential for nerve and muscle function and fluid balance, though the supplement form raises intake concerns for people on blood pressure or heart medications.

Cranberry concentrate brings the tart, fruity flavor and the polyphenols credited with urinary tract and broader health effects. The remaining ingredients—corn syrup, sugar, gelatin, citric acid, natural flavor, pectin, vegetable oil, and natural palm leaf glaze—are inactive components that give the gummy its texture, taste, and shelf life.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Urinary tract and bladder health.
  • We looked for evidence on: Urinary tract infections (UTIs), Overactive bladder, Urinary odor, Radiation-induced cystitis, Catheter-related infections, Cystitis — and 1 related terms.
  • The strongest evidence on file: Cranberry is rated "Possibly Effective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Cranberry is rated "Insufficient Reliable Evidence To Rate" for Urinary odor, Overactive bladder, Catheter-related infections, Radiation-induced cystitis.

Cranberry in these gummies is possibly effective for urinary tract infections (UTIs), meaning there's some clinical support for this use but it's not definitive. Evidence for other uses—age-related cognitive decline, benign prostate enlargement, cancer prevention, fatty liver disease, and chronic fatigue—isn't established in our data.

Sodium's effectiveness rating applies mainly to medical contexts (cystic fibrosis, managing nephrotoxicity from certain cancer drugs, or bipolar disorder), not to general health or the amounts in a cranberry gummy.

The evidence, ingredient by ingredient Sodium Cranberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cranberry in normal food amounts is generally well tolerated. The main side effects reported in studies are diarrhea and gastrointestinal discomfort, especially at very high doses or in young children.

Sodium is safe in normal dietary amounts but the safety data advises caution—too much is linked to high blood pressure and heart strain. The concerns with both ingredients center on dose and individual health status: if you're managing blood pressure, heart disease, kidney disease, or taking medications that affect sodium or blood thinning, you'll want to discuss this product with your doctor or pharmacist first.

Pregnancy and lactation safety data for sodium is mixed (rated both likely safe and possibly unsafe), so there isn't enough certainty to recommend it without medical guidance; cranberry is rated likely safe in pregnancy and lactation.

Side effects, ingredient by ingredient Sodium Cranberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Cranberry, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 863 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take blood pressure medications (antihypertensives), blood thinners like warfarin, statin cholesterol drugs like atorvastatin, calcium channel blockers like nifedipine, lithium, corticosteroids, or any sodium-containing drugs or supplements. Cranberry and sodium can both alter how these medications work, and in some cases may require monitoring or dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support urinary tract health with cranberry and you don't take medications for blood pressure, heart function, blood thinning, or cholesterol, these gummies are generally well tolerated. But if you do take any of those medications—or lithium, corticosteroids, or other drugs affected by sodium or cranberry—talk with your doctor or pharmacist before starting.

They'll want to make sure the sodium and cranberry won't interfere with how your medications work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cranberry Gummies Cran-Raspberry Flavored, straight from the product label.

Brand Sundown
Barcode (UPC) 030768553180
Net contents 75 Gummy(ies)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 272813
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cranberry Gummies Cran-Raspberry Flavored by Sundown, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gummie(s)
Maximum serving Sizes:
5 Gummie(s)
Servings per container
15
UPC/BARCODE
030768553180
IngredientAmount% DV
Calories45 Calorie(s)--
Total Carbohydrates11 Gram(s)4%
Sodium10 mg1%
Total Sugars7 Gram(s)--
added Sugars7 Gram(s)14%
Pacran Cranberry concentrate powder500 mg--

Other ingredients: Corn Syrup, Sugar, Gelatin, Citric Acid, Natural flavor, Pectin, Vegetable Oil, natural Palm leaf glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean nutrition Sundown believes in clean nutrition and being transparent. That's why you won't find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products.

US Only Discard Seal, Empty & Replace Cap Plastic bottle How2recycle.info

Formulation

That's why you won't find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products. Non-GMO - No gluten - No wheat - No milk - No lactose - No artificial color - No artificial flavor - No artificial sweetener - No soy - No starch - No yeast - No peanuts - No tree nuts - No fish

Made in the USA with select ingredients from around the world

Gluten free Dairy free

Supports healthy urinary tract function

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of the reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store at room temperature and avoid excessive heat.

Brand IP Statement(s)

Pacran Pacran is a trademark of Naturex Inc. Copyright 2021

Formula

Cranberry Gummies 500 mg per serving Pacran 50:1 concentrate

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, chew five (5) gummies daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cranberry Gummies Cran-Raspberry Flavored by Sundown label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cranberry Gummies Cran-Raspberry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cranberry Gummies Cran-Raspberry Flavored by Sundown

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Gummie(s) Dosage formGummy Or Jelly Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Pacran Cranberry concentrate powder

Interacts with
712 drugs
500 mg per serving

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...

Pacran Cranberry concentrate powder monograph & interactions

Other (inactive) ingredients: Corn Syrup, Sugar, Gelatin, Citric Acid, Natural flavor, Pectin, Vegetable Oil, Natural Palm leaf glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cranberry Gummies Cran-Raspberry Flavored by Sundown Drug Interactions

Want to check YOUR meds against Cranberry Gummies Cran-Raspberry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
862Drugs
804 Moderate 58 Minor

Ingredients driving the most interactions

Pacran Cranberry concentrate powder 712
Sodium 205

Individual Drug Interactions

The ingredients in Cranberry Gummies Cran-Raspberry Flavored interact with 862 drugs. Click any drug to see the details.

2 of the 2 ingredients in Cranberry Gummies Cran-Raspberry Flavored interact with drugs. Each result below shows which ingredient is responsible. Pacran Cranberry concentrate powder Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Cranberry Gummies Cran-Raspberry Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pacran Cranberry concentrate powder6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Pacran Cranberry concentrate powder full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cranberry Gummies Cran-Raspberry Flavored, from the product label.

Sundown

See all Sundown products
Name
Rexall Sundown, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-888-848-2435
Web Address
www.sundownnutrition.com
Pharmacist Counseling Corner

Cranberry Gummies Cran-Raspberry Flavored by Sundown: Common Questions

Does Cranberry Gummies Cran-Raspberry Flavored by Sundown interact with any medications?
Yes. Based on its ingredients, Cranberry Gummies Cran-Raspberry Flavored has a known interaction with 862 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cranberry Gummies Cran-Raspberry Flavored contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will these gummies help me prevent or treat a urinary tract infection?
Cranberry is possibly effective for UTIs, meaning some clinical evidence supports it—but it's not a proven cure. These gummies are a supplement, not a medical treatment. If you think you have a UTI, see your doctor; they can confirm it and prescribe antibiotics if needed. Cranberry may play a preventive role for some people, but only if discussed with your healthcare provider first.
What's in this product besides cranberry?
The active ingredient is Pacran cranberry concentrate powder and sodium. The rest—corn syrup, sugar, gelatin, citric acid, natural flavor, pectin, vegetable oil, and natural palm leaf glaze—are inactive fillers and binders that make it a gummy and give it flavor.
Can I take these if I'm pregnant or breastfeeding?
Cranberry is rated likely safe during pregnancy and lactation, but sodium's safety data is mixed and includes a possibly unsafe rating. There isn't enough certainty about sodium in this context. Talk with your doctor or pharmacist before taking these gummies while pregnant or breastfeeding so they can weigh the cranberry benefit against the sodium concern for your situation.
What side effects might I experience?
The most common side effect from cranberry is diarrhea or gastrointestinal discomfort, especially at high doses. Stomach upset, nausea, and vomiting have been reported in some people taking cranberry supplements. Sodium at excess doses can raise blood pressure and strain the heart, but normal dietary amounts are fine for most people.
Are these gummies safe if I have high blood pressure?
If you take blood pressure medications, the sodium in these gummies could reduce their effectiveness, and you may need a dose adjustment to keep your blood pressure controlled. Check with your doctor or pharmacist before taking them—they'll want to know if extra sodium could interfere with your treatment plan.
Can I take these with my statin or blood thinner?
Cranberry may boost the levels of statin drugs like atorvastatin and blood thinners like warfarin, which could raise your side-effect risk or change how well they work. One case report linked concentrated cranberry juice to muscle pain and liver problems in someone taking atorvastatin. Talk with your doctor or pharmacist before adding this product if you're on either type of drug—they may want to monitor you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cranberry Gummies Cran-Raspberry Flavored label
Go deeper

The Full Monographs Behind Cranberry Gummies Cran-Raspberry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph →
Sources

Sources & How We Checked

Cranberry Gummies Cran-Raspberry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
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Cranberry 33 references
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See these in context on the Cranberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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