Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

D.L. Duo-Dophilus Ingredients & Drug Interactions

by Douglas Laboratories

D.L. Duo-Dophilus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D.L. Duo-Dophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D.L. Duo-Dophilus is a dietary supplement by Douglas Laboratories with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D.L. Duo-Dophilus by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with D.L. Duo-Dophilus by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D.L. Duo-Dophilus by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

D.L. Duo-Dophilus is a three-ingredient probiotic capsule.

The active ingredients are Acidophilus (a live beneficial bacterium), FOS (a type of fiber that feeds good bacteria), and Bifidus (another beneficial bacterium). These are supported by inactive ingredients including gelatin, cellulose, and vegetable stearate, which form and hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lactobacillus Acidophilus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lactobacillus Acidophilus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Acidophilus has been studied for several digestive and immune concerns. The data shows it's possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

For atopic disease (allergic conditions), the evidence suggests it's probably not effective. For acute respiratory distress syndrome, there isn't enough reliable evidence to say one way or the other.

We don't have effectiveness data on file for FOS or Bifidus in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acidophilus is generally well tolerated in healthy adults and children. However, because it contains live organisms, there's a theoretical concern it could cause infection in certain patients — though most documented cases appear to occur in people with specific underlying conditions.

Orally, taking it may occasionally cause mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea; these are uncommon. Rarely, rash and itching have been reported, though it's unclear whether the probiotic itself or another ingredient was responsible.

During pregnancy, Acidophilus is rated possibly safe, though data are limited. We don't have pregnancy or lactation safety information on file for FOS or Bifidus.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic medications before taking this product — Moderate-severity interactions are documented. Specifically, taking antibiotics and this probiotic at the same time may reduce the effectiveness of the live organisms.

Ask your doctor or pharmacist how to space them apart.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This three-ingredient probiotic may help with certain digestive complaints and bacterial imbalances, particularly if you're dealing with antibiotic-associated diarrhea or IBS. The main thing to watch for is taking it at the same time as antibiotics — space them apart instead.

Since we couldn't check two of the three ingredients for interactions, and safety data are limited, talk with your doctor or pharmacist before starting it, especially if you have a weakened immune system or are pregnant.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D.L. Duo-Dophilus, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539017777
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10056
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D.L. Duo-Dophilus by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
310539017777
IngredientAmount% DV
Acidophilus2000000000 CFU--
FOS109 mg--
Bifidus2000000000 CFU--

Other ingredients: Lactobacillus acidophilus Complex, lactobacillus bifidus complex, Gelatin, Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 or more capsules daily or as directed by physician.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

General Statements

Meets Douglas Laboratories spec [#81433]. Conforms to USP <2091> for weight. Meets USP <2040> for disintegration.

General

Formula #81433

Storage

For optimal storage conditions, keep refrigerated with lid tightly sealed after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D.L. Duo-Dophilus by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D.L. Duo-Dophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D.L. Duo-Dophilus by Douglas Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acidophilus

Interacts with
182 drugs
2000000000 CFU per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Acidophilus monograph & interactions

FOS

109 mg per serving

Bifidus

2000000000 CFU per serving

Other (inactive) ingredients: Lactobacillus acidophilus Complex, Lactobacillus bifidus complex, Gelatin, Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

D.L. Duo-Dophilus by Douglas Laboratories Drug Interactions

Want to check YOUR meds against D.L. Duo-Dophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Acidophilus 182

Individual Drug Interactions

The ingredients in D.L. Duo-Dophilus interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in D.L. Duo-Dophilus interact with drugs. Each result below shows which ingredient is responsible. Acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in D.L. Duo-Dophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D.L. Duo-Dophilus, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

D.L. Duo-Dophilus by Douglas Laboratories: Common Questions

Does D.L. Duo-Dophilus by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, D.L. Duo-Dophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D.L. Duo-Dophilus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work if I'm on antibiotics?
Not if you take them together. Antibiotics kill the live bacteria in this supplement, so it won't be as effective. Space your antibiotic doses a few hours apart from this product — your pharmacist can help you schedule them.
What are these bacteria supposed to do?
Acidophilus and Bifidus are beneficial bacteria that live naturally in your gut. They may help restore balance after antibiotics, reduce IBS symptoms, and support digestive and immune health. FOS is a type of fiber that feeds these good bacteria.
Can I take this while pregnant?
Acidophilus is rated possibly safe in pregnancy, but data are limited. We don't have safety information for FOS or Bifidus during pregnancy. Talk with your doctor or pharmacist before starting it to make sure it's right for you.
What side effects should I watch for?
Most people tolerate it well. Occasionally, people report mild bloating, gas, abdominal discomfort, or diarrhea — these are uncommon. Rarely, rash and itching have been reported, though it's unclear if the probiotic itself caused them.
Is this safe if my immune system is weak?
Probiotics containing live organisms carry a theoretical risk of infection in certain patients. If you have a weakened immune system, check with your doctor or pharmacist before taking this product.
Does this have fillers or just the active ingredients?
It has a few inactive ingredients — gelatin, cellulose, and vegetable stearate — that form and hold the capsule. They're not active ingredients, just the structure the capsule needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D.L. Duo-Dophilus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D.L. Duo-Dophilus label
Go deeper

The Full Monographs Behind D.L. Duo-Dophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

D.L. Duo-Dophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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