No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

D-Mannose 1000 mg Ingredients & Drug Interactions

by Nutricost

D-Mannose 1000 mg label
See full label image
Capsule Category: Fiber And Other Nutrients
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Mannose 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

D-Mannose 1000 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of D-Mannose 1000 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nutricost D-Mannose contains one active ingredient: D-mannose, a simple sugar that your body can use or excrete without insulin. The product also includes inactive ingredients—gelatin, rice flour, stearic acid, silicon dioxide, and vegetable magnesium stearate—which serve as fillers, binders, and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded D-mannose's overall clinical evidence instead.

Strong

Strong clinical evidence supports D-mannose for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Carbohydrate-deficient glycoprotein syndrome type 1b — rated "Likely Effective" (Natural Medicines).

The evidence for D-mannose is mixed. For carbohydrate-deficient glycoprotein syndrome type 1b, it is likely effective.

For urinary tract infections (UTIs), the data suggests it is possibly ineffective — meaning the evidence does not support its use for that purpose.

The evidence, ingredient by ingredient D-mannose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-mannose is generally well tolerated in the short term, but high-quality long-term safety data are limited, so extended use should be discussed with your doctor. The most common side effects are bloating, diarrhea, and nausea.

Higher doses (over 200 mg per kilogram of body weight) are more likely to trigger osmotic diarrhea — the kind caused by unabsorbed sugar drawing fluid into your bowel. Safety data during pregnancy and breastfeeding are not adequate to know either way.

If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product — there isn't enough information to say whether it's safe for you.

Side effects, ingredient by ingredient D-mannose

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for D-mannose. That doesn't mean interactions can't happen — it means we haven't found documented ones.

Check your exact medications with the tool on this page, and talk with your doctor or pharmacist before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

D-mannose may be worth considering if you have carbohydrate-deficient glycoprotein syndrome type 1b under your doctor's guidance, but the evidence does not support it for UTIs. Long-term safety data are limited, and side effects like diarrhea and bloating are possible, especially at higher doses.

Talk with your doctor or pharmacist about whether this product makes sense for you and how long you should take it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Mannose 1000 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 702669935845
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 223119
Product type Fiber And Other Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Mannose 1000 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
702669935845
IngredientAmount% DV
D-Mannose1000 mg--

Other ingredients: Gelatin, Rice Flour, Stearic Acid, Silicon Dioxide, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement. take 2 capsules with 8-12 oz of water, or as directed by your physician.

Precautions

Warning: This product is only intended to be consumed by healthy individuals 18 years of age or older.

Consult a physician prior to use it pregnant or nursing.

Do not exceed recommended use. Improper use will not improve results and is not advised.

Keep out of reach of children.

Do not use if safety seal is broken.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

D-Mannose 1,000 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Nutricost Quality guaranteed Made in the USA

Formulation

Non GMO Gluten free product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Mannose 1000 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Mannose 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Mannose 1000 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

D-Mannose

No known
interactions
1000 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Stearic Acid, Silicon Dioxide, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Mannose 1000 mg by Nutricost Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 1000 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for D-Mannose 1000 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

D-Mannose 1000 mg by Nutricost: Common Questions

Does D-Mannose 1000 mg by Nutricost interact with any medications?
We do not currently list a known interaction for the mapped ingredients in D-Mannose 1000 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
D-Mannose 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough data on D-mannose to know whether it's safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice — they can help you weigh the pros and cons for your situation.
What side effects might I notice?
The most common ones are bloating, diarrhea, and nausea. Higher doses are more likely to cause osmotic diarrhea (loose stools from unabsorbed sugar). Most people tolerate it well in the short term, but long-term safety data are limited.
How long can I safely take D-mannose?
Short-term use is generally well tolerated, but high-quality long-term safety data are limited. If you're planning to take it for more than a few weeks, check with your doctor or pharmacist about the right duration for you.
Does this work for urinary tract infections?
No — the evidence suggests D-mannose is possibly ineffective for UTIs. If you're treating a UTI, talk with your doctor about options that do have solid evidence backing them.
What is D-mannose, and what does it do in my body?
D-mannose is a simple sugar. Your body can either use it for energy or excrete it in your urine without needing insulin to process it — which is why it's studied for certain genetic conditions like carbohydrate-deficient glycoprotein syndrome type 1b.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Mannose 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Mannose 1000 mg label
Go deeper

The Full Monographs Behind D-Mannose 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph →
Sources

Sources & How We Checked

D-Mannose 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

D-mannose 6 references
  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

See these in context on the D-mannose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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