D-Mannose 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 mg is a dietary supplement by Absorb Health with 2 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 mg by Absorb Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring simple sugar. D-mannose is not broken down or used by your body the way regular sugars are — instead, it passes through your system largely unchanged and is excreted in urine, which is why it's been studied for urinary health.
The capsule itself is made from gelatin, microcrystalline cellulose (a plant-derived thickener), and silica (an anti-caking agent) — standard inactive ingredients that help hold the capsule together and keep the powder from clumping.
Does it work?
Leans against
The evidence for D-mannose is mixed. It is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare inherited metabolic condition — this is the clearest finding in the data we hold.
For urinary tract infections, however, the evidence suggests it is possibly ineffective, meaning studies haven't shown it reliably works for that purpose despite its popularity for that use. If you're considering it for UTI prevention or treatment, talk with your doctor or pharmacist about whether it's the right choice for you.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data from high-quality studies are limited — we simply don't have enough solid evidence about what happens if you take it regularly for months or years. Pregnancy and breastfeeding safety haven't been well studied, so the safety data advises caution during both.
The most common side effects are digestive: bloating, loose stools, diarrhea, and nausea. Diarrhea is more likely if you take a very large single dose (over 200 mg per kilogram of body weight), but looser stools and bloating have been reported even at lower doses.
If you're pregnant, breastfeeding, or planning to become pregnant, talk with your doctor or pharmacist before starting — they can weigh the possible benefits against what we don't yet know.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That said, since it's a sugar that passes through your digestive tract, spacing it away from medications that need precise timing or stomach conditions — like certain antibiotics — may be wise.
Check with your pharmacist about your specific medications before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is well suited for the rare metabolic condition it's been shown to help, but the evidence it works for UTIs is weak. If you're considering it for urinary health, discuss that plan with your doctor or pharmacist first.
Digestive side effects are common, especially at higher doses. If you're pregnant or breastfeeding, get personalized advice from your healthcare provider before taking it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500 mg, straight from the product label.
| Brand | Absorb Health |
|---|---|
| Barcode (UPC) | 790566991224 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2020 |
| DSLD ID | 215766 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 mg by Absorb Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 6 Calorie(s) | -- |
| Total Carbohydrates | 1.5 Gram(s) | -- |
| Sugar | 1.5 Gram(s) | -- |
| D-Mannose | 1.5 Gram(s) | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of the reach of children.
Do not use if seal under cap is broken or missing.
Storage
Store at room temperature with lid tightly closed.
Formulation
Urinary Tract Support
No cutting agents
General Statements
Shop at www.absorbyourhealth.com for all your mind, body, and spirit needs.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 mg by Absorb Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 mg by Absorb Health
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 mg by Absorb Health Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500 mg, from the product label.
Absorb Health
See all Absorb Health products- Name
- Absorb Health
- Street Address
- 4705 Southport-Supply Rd., #202
- City
- Southport
- State
- NC
- ZipCode
- 28461
- Web Address
- www.absorbyourhealth.com
D-Mannose 500 mg by Absorb Health: Common Questions
Does D-Mannose 500 mg by Absorb Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat a urinary tract infection?
What are the most common side effects?
Is it safe to take long-term?
Can I take it if I'm pregnant or breastfeeding?
What is D-mannose and how does it work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC