D-Mannose 500 mg Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 mg by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar your body uses in various metabolic pathways. It's the sole active component in each capsule.
The inactive ingredients (hypromellose, rice flour, stearic acid, magnesium stearate, and silicon dioxide) are excipients — they form the capsule, improve texture, and help with processing.
Does it work?
Leans against
The evidence for D-mannose is mixed. For carbohydrate-deficient glycoprotein syndrome type 1b, it's rated likely effective based on available research.
For urinary tract infections (UTIs), however, the rating is possibly ineffective — meaning the evidence does not support its use for that purpose, despite its popularity for that reason.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, though long-term safety data are limited — if you're thinking of using it for months on end, that's worth a conversation with your doctor. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea risk increases at higher doses; taking more than 200 mg per kilogram of body weight in a single dose is more likely to trigger osmotic diarrhea (loose stools from the sugar drawing water into the bowel). There isn't enough reliable safety data to recommend D-mannose in pregnancy — talk with your doctor before using it if you're pregnant or planning to become pregnant.
Safety while breastfeeding hasn't been well studied either, so caution is advised if you're nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That doesn't mean none exist — it means this ingredient hasn't shown interactions in the studies we hold.
Before adding it to your routine, run your medications by your own doctor or pharmacist to be thorough.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose may help with carbohydrate-deficient glycoprotein syndrome type 1b if that's your situation, but evidence does not support its use for UTIs. It's generally well tolerated short-term, though bloating and diarrhea are common, especially at higher doses.
Pregnant or breastfeeding women should talk with their doctor before starting it, and anyone taking it long-term should check in with their pharmacist or doctor about the limited long-term safety data.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500 mg, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739028112 |
| Net contents | 120 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 245572 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1.5 Gram(s) | 1% |
| Total Sugars | 1.5 Gram(s) | -- |
| D-Mannose | 1.5 Gram(s) | -- |
Other ingredients: Hypromellose, Rice Flour, Stearic Acid, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 3 capsules 1 to 3 times daily. Take with water or unsweetened juice, such as unsweetened cranberry juice.
Formula
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It's metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won't interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Healthy urinary tract Cleanses the bladder
Non-GMO
Vegetarian/Vegan
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
Storage
Store in a cool, dry place after opening.
Seals/Symbols
Non-GMO Project Verified Nongmoproject.org
Triangle K (Kosher)
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
General Statements
General Health Family owned since 1968.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 mg by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 mg by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Veg Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 mg by NOW Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500 mg, from the product label.
NOW
See all NOW products- Name
- NOW Foods
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
D-Mannose 500 mg by NOW: Common Questions
Does D-Mannose 500 mg by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help with my UTI?
What side effects should I watch for?
Is D-mannose safe to take long-term?
Can I take D-mannose while pregnant?
Is it safe to breastfeed while taking D-mannose?
What is D-mannose, and what does it do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC