d-Mannose Ingredients & Drug Interactions
What is this page for?
First and foremost: checking d-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
d-Mannose is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of d-Mannose by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This powder contains a single active ingredient: D-mannose, a simple sugar. D-mannose is used to support urinary tract health by a proposed mechanism of binding to certain bacteria and helping flush them from the urinary system.
The product contains no inactive fillers or other ingredients.
Does it work?
Strong evidence
The evidence for D-mannose in urinary tract infections is mixed. Our data rates it possibly ineffective for preventing or treating UTIs — meaning the quality of evidence doesn't support a clear benefit.
D-mannose is rated likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic condition, but that's a specialized medical use outside typical supplement shopping. For routine urinary tract health, the evidence doesn't establish that this product works as often promoted.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but high-quality long-term safety data are limited — so we don't have a solid track record of safety over months or years. The most common side effects are bloating, diarrhea, and nausea, especially at higher doses or if you're sensitive to it.
Loose stools and abdominal bloating have been reported in children, and diarrhea has occurred in adults taking 2 grams daily for 6 months. Doses above 200 mg per kilogram of body weight are more likely to cause osmotic diarrhea (loose stools from the sugar pulling water into your gut).
Pregnancy safety data aren't available — there isn't enough information to know whether it's safe during pregnancy, so talk with your doctor or pharmacist for personalized advice. Safety while breastfeeding is also not well studied, so caution is advised if you're nursing.
Meds to double-check
No known interactions
No interactions are documented for D-mannose with any medications in our data. That doesn't mean none could occur in an individual, so if you're on prescription drugs or have any concerns, check with your doctor or pharmacist before adding this product.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-Mannose might appeal to someone looking for a natural approach to urinary tract support, but the evidence that it actually works for UTIs isn't strong. It's generally well tolerated short-term, though bloating and diarrhea can happen — especially at higher doses.
Because long-term safety data are thin and pregnancy and breastfeeding safety aren't well established, talk with your doctor or pharmacist before starting it, particularly if you're pregnant, nursing, or planning to take it for a long time.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about d-Mannose, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539025185 |
| Net contents | 50 Gram(s); 1.76 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2022 |
| DSLD ID | 261023 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for d-Mannose by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 scoop 3 times daily or as directed by your health professional.
Precautions
Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.
Keep out of the reach of children.
Use only if safety seal is intact.
Storage
Store in a cool, dry place.
Formulation
Gluten-free, Non-GMO
Support for urinary tract health
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Packaged by weight, not volume. Settling may occur. Scan to learn about our manufacturing excellence
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
d-Mannose by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in d-Mannose by Douglas Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Scoop(s) Dosage formPowder Servings per container55 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
d-Mannose by Douglas Laboratories Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in d-Mannose. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for d-Mannose, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Phone Number
- 1.800.245.4440
- Web Address
- www.douglaslabs.com
d-Mannose by Douglas Laboratories: Common Questions
Does d-Mannose by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is D-mannose and what is it supposed to do?
What are the most common side effects?
Is it safe to take D-mannose long-term?
Can I take D-mannose while pregnant or breastfeeding?
Does D-mannose interact with any medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if d-Mannose is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind d-Mannose’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
d-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC