D-Mannose Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose Powder is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose Powder by Protocol For Life Balance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar. It's included because some research suggests it may help with certain conditions affecting how your body processes carbohydrates and glycoproteins—complex molecules made of sugar and protein.
The product is a powder with no other inactive ingredients listed.
Does it work?
Leans against
D-mannose is rated likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic condition affecting how your body makes and uses certain proteins. For urinary tract infections (UTIs), though, the evidence we hold rates it as possibly ineffective—meaning the data don't support it as a reliable treatment for that purpose.
How safe is it?
Well-documented data
D-mannose is generally well tolerated over the short term, but we don't have strong long-term safety data, so extended use is something to discuss with your doctor. The most common side effects are bloating, diarrhea, and nausea.
Higher doses—especially a single dose over 200 mg/kg (roughly 14 grams for a 150-pound adult)—are more likely to cause osmotic diarrhea (loose stools from the sugar drawing water into your bowel). Safety during pregnancy is not well studied, so the data advise against use during pregnancy unless your doctor recommends it.
Safety while breastfeeding is also not well studied; caution is advised, and you should talk it over with your healthcare provider.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, confirm with your own doctor or pharmacist before adding this to your medications, since our data are not exhaustive.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is a reasonable choice if your doctor has recommended it for carbohydrate-deficient glycoprotein syndrome type 1b. It's not reliable for UTIs based on current evidence.
Keep in mind side effects like bloating and diarrhea are possible, especially at higher doses. Run this by your own doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or planning to use it long-term.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose Powder, straight from the product label.
| Brand | Protocol For Life Balance |
|---|---|
| Barcode (UPC) | 707359128101 |
| Net contents | 3 oz.; 85 Gram(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2017 |
| DSLD ID | 73732 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose Powder by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Total Sugars | 2 Gram(s) | -- |
| D-Mannose | 2 Gram(s) | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 level teaspoon 1 to 2 times daily with water or unsweetened juice, or as directed by your healthcare practitioner.
General Statements
How It Works: D-Mannose is a simple sugar that is taken up in the GI tract and rapidly excreted in the urine without affecting blood sugar regulation.* D-Mannose helps to support a normal environment within the bladder by maintaining a healthy mucosal lining and promoting proper flushing of foreign particles.* Clinical studies indicate that D-Mannose can help to maintain normal urinary tract health when used regularly.*
Natural color variation may occur in this product.
~ Promotes flushing or foreign particles* ~ Supports a healthy urinary tract*
This product is sold by weight not volume.
Precautions
Cautions/Interactions: There are no known drug interactions. May cause mild, but transient GI discomfort.
Do not eat freshness packet enclosed.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
CODE P2810 V5
Seals/Symbols
Non-GMO
Formulation
Non-GMO
Vegetarian/Vegan
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose Powder by Protocol For Life Balance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose Powder by Protocol For Life Balance
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 tsp Dosage formPowder Servings per container43 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
D-Mannose Powder by Protocol For Life Balance Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose Powder, from the product label.
Protocol For Life Balance
See all Protocol For Life Balance products- Name
- Protocol For Life Balance
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- www.protocolforlife.com
D-Mannose Powder by Protocol For Life Balance: Common Questions
Does D-Mannose Powder by Protocol For Life Balance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take D-Mannose Powder while pregnant?
Is D-Mannose Powder safe while breastfeeding?
Does D-Mannose Powder help with urinary tract infections?
What are the main side effects I might experience?
Is this product just D-Mannose, or are there other ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC