D-Mannose Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose Powder is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose Powder by Pure Encapsulations
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar (carbohydrate) that your body uses or passes into urine. The powder form lets you mix it into liquid or food.
There are no inactive ingredients listed.
Does it work?
Strong evidence
D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic disorder affecting how your body makes certain proteins. For urinary tract infections (UTIs), the evidence we hold rates it as possibly ineffective — meaning the data don't support its use for that purpose.
If you're considering it for UTI prevention or treatment, talk with your doctor about whether it's right for your situation.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but we don't have high-quality long-term safety data, so ongoing use should be guided by your doctor. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea is more likely at higher doses — a single dose over 200 mg/kg can trigger osmotic diarrhea (loose stools from fluid drawn into the bowel). During pregnancy, there isn't enough reliable safety data, so it's best to avoid it unless your doctor advises otherwise.
Safety while breastfeeding is not well studied; caution is advised, and you should discuss it with your doctor or pharmacist.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That said, check your complete medication list with your doctor or pharmacist before you start, especially if you're taking any medications for blood sugar control or if you have any digestive conditions.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose has solid evidence for treating a specific genetic disorder, but not for UTI prevention. It's generally well tolerated short-term, though long-term safety data are limited.
If you're pregnant, breastfeeding, or planning to take it regularly, talk with your doctor or pharmacist before starting — they can help you weigh the benefits and risks for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose Powder, straight from the product label.
| Brand | Pure Encapsulations |
|---|---|
| Barcode (UPC) | 766298007649 |
| Net contents | 3.5 Oz(s); 100 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jan 7, 2019 |
| DSLD ID | 182853 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose Powder by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| D-Mannose | 0.9 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommendations: As a dietary supplement, take 1 scoop, 3 times daily, mixed with water, with or between meals.
Precautions
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
General Statements
Packaged by weight, not volume. Settling may occur.
Scan to learn about our hypoallergenic supplements
Supports urinary tract health
Formulation
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org
Gluten-free, Non-GMO & Hypoallergenic
Gluten-free, Non-GMO & Hypoallergenic
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
GF
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
v5 code: DMP1
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose Powder by Pure Encapsulations label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose Powder by Pure Encapsulations
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.9 Gram(s) Dosage formPowder Servings per container111 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsD-Mannose Powder by Pure Encapsulations Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose Powder, from the product label.
Pure Encapsulations
See all Pure Encapsulations products- Name
- Pure Encapsulations
- Street Address
- 490 Boston Post Road
- City
- Sudbury
- State
- MA
- Phone Number
- 1-800-753-2277
- Web Address
- www.PureEncapsulations.com
D-Mannose Powder by Pure Encapsulations: Common Questions
Does D-Mannose Powder by Pure Encapsulations interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is D-mannose and what is it used for?
What are the side effects?
Is it safe to take during pregnancy?
Is it safe while breastfeeding?
Can I take D-mannose long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC