Interactions on record — worth a quick check against your medications. Based on 3 of 12 ingredients. Check your meds →
Dietary supplement

Digest Ingredients & Drug Interactions

by Enzymedica

Digest label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest is a dietary supplement by Enzymedica with 12 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Protease Thera-blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digest by Enzymedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest by Enzymedica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digest by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.

Enzymedica Digest is a blend of 12 digestive enzymes designed to help break down food. Lactase breaks down lactose (the sugar in milk), while Lipase Thera-blend helps digest fats.

The other ten ingredients include enzymes that work on carbohydrates and proteins — Amylase, Protease, Cellulase, and several others — to support overall digestion. The capsules also contain cellulose and water as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support optimal digestion and nutrient absorption.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Gas and bloating, Indigestion, Digestive discomfort.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Lactase in this product is effective for lactose intolerance. For the other enzymes — Lipase and the rest — the evidence we have doesn't yet establish whether they work for indigestion or other digestive complaints.

There's insufficient evidence to rate their use for those purposes. If you're taking Digest mainly for lactose intolerance, that's where the science supports it; for broader digestive support, talk with your pharmacist about what the research shows.

The evidence, ingredient by ingredient Lactase Lipase Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated. Lipase is also generally well tolerated in supplement form, though people with serious digestive conditions should only use it under medical guidance.

Both have limited safety data in pregnancy and breastfeeding — the facts advise checking with your doctor before regular use during pregnancy and before using while nursing. One case of allergic reaction to powdered lactase has been reported (contact dermatitis and allergic rhinoconjunctivitis in a worker exposed to it); this is very rare.

No other adverse effects have been reported in adults taking these enzymes as supplements.

Side effects, ingredient by ingredient Lactase Lipase Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

No interactions are documented in our data for the ingredients we could check. That said, we hold no interaction data for the majority of the enzymes in this product, so if you're on any medications, use the interaction checker on this page with your specific drugs to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have trouble digesting lactose, Digest's lactase can help. If you're taking it for general digestive support, the evidence doesn't yet back that use — worth a conversation with your pharmacist.

Because we couldn't check most of the enzymes in this blend, run your exact medications through the tool below if you're on prescriptions. And if you're pregnant, nursing, or have a serious digestive condition, talk to your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480981115
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328876
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
670480981115
IngredientAmount% DV
Lactase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Maltase0 NP--
Hemicellulase0 NP--
Cellulase Thera-blend0 NP--
Lipase Thera-blend0 NP--
Amylase Thera-blend0 NP--
Protease Thera-blend0 NP--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enzymedica supports Vitamin angels Proud supporter

Complete #1 selling enzyme brand

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Enzyme deficiencies may result from a combination of age, diet and lifestyle. These deficiencies can lead to a variety of digestive discomforts, including occasional gas, bloating, indigestion and irregularity. Digest is an enhanced formula that breaks down carbohydrates, fats, fiber and protein. Digestive well-being improves concentration and increases vitality.

No fillers added

Made in USA with global ingredients

Non GMO

Digestive Enhanced digestive support Twice the enzyme power of Digest Basic

Vegan & Kosher

Contains no: gluten, milk, casein, soy, egg, artificial colors or flavors

Formula

The enzymes included in Digest support optimal digestion by helping the body absorb nutrients and convert food into energy. Thera-blend enzymes are comprised of multiple variants which are blended to work synergistically throughout the broad pH range of the human body.

Complete Enzyme Formula

Vegan & Kosher

Suggested/Recommended/Usage/Directions

Recommended use: 1 capsule with each meal. More may be taken as needed. For higher enzyme potency, Enzymedica's Digest Gold may be helpful.

Brand IP Statement(s)

Enzymedica The enzyme experts

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

KOF-K (Kosher) Parve #K1840

Autism Hope Alliance AHA Green Mountain Energy

Precautions

Do not use if safety seal is broken or missing.

Please keep out of reach of children

Storage

Keep closed in dry place; avoid excessive heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest by Enzymedica

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactase

No known
interactions
0 NP per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Invertase

0 NP per serving

Glucoamylase

0 NP per serving

Alpha-Galactosidase

0 NP per serving

Xylanase

0 NP per serving

Pectinase

0 NP per serving

Maltase

0 NP per serving

Hemicellulase

0 NP per serving

Cellulase Thera-blend

0 NP per serving

Lipase Thera-blend

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase Thera-blend monograph & interactions

Amylase Thera-blend

0 NP per serving

Protease Thera-blend

Interacts with
2 drugs
0 NP per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Protease Thera-blend monograph & interactions

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest by Enzymedica Drug Interactions

Want to check YOUR meds against Digest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Protease Thera-blend 2

Individual Drug Interactions

The ingredients in Digest interact with 2 drugs. Click any drug to see the details.

1 of the 12 ingredients in Digest interact with drugs. Each result below shows which ingredient is responsible. Protease Thera-blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Protease Thera-blend1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Protease Thera-blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292
Phone Number
1-888-918-1118
Web Address
enzymedica.com
Pharmacist Counseling Corner

Digest by Enzymedica: Common Questions

Does Digest by Enzymedica interact with any medications?
Yes. Based on its ingredients, Digest has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with lactose intolerance?
Yes — lactase is effective for lactose intolerance. That's the one ingredient in Digest we have solid evidence for. If that's your main reason for taking it, you're on the right track.
Can I take this while I'm pregnant?
Lactase is likely safe in pregnancy, but the facts advise checking with your doctor before regular use. Lipase has limited safety data in pregnancy, so ask your doctor before starting. For the other enzymes, we don't have pregnancy data on file.
Can I take this while breastfeeding?
Lactase acts only in the gut, so it's probably okay — but ask your doctor or pharmacist first. Lipase hasn't been well studied while breastfeeding, so check with your healthcare provider. We don't have breastfeeding data for the other enzymes in the blend.
Will this help my indigestion?
We don't have enough evidence to say whether the enzymes in Digest work for indigestion or general digestive support. If lactose isn't your issue, talk with your pharmacist about whether this is the right choice for you.
Are there any side effects?
No adverse effects have been reported in adults taking these enzymes as supplements. Very rarely, someone may have an allergic reaction to lactase itself (contact dermatitis or allergic rhinitis in workers exposed to powdered lactase has been reported once). If you have a serious digestive condition, use only under medical guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest label
Go deeper

The Full Monographs Behind Digest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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