Bioflavonoids 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bioflavonoids 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bioflavonoids 500 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bioflavonoids 500 mg by Nature's Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Bioflavonoids 500 mg by Nature's Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bioflavonoids 500 mg by Nature's Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 3 active bioflavonoid ingredients: Hesperidin Complex, Rutin Complex, and Lemon Bioflavonoid Complex. Bioflavonoids are plant compounds with antioxidant properties found naturally in fruits, vegetables, and citrus.
They're included in supplements for their potential health benefits, though the effectiveness of each for specific conditions varies and isn't always well established. The product also contains several inactive ingredients — cellulose, rose hips, acerola juice powder, green pepper, stearic acid, and silica — which are fillers, binders, and other materials that help form and stabilize the tablet.
Does it work?
Not established
The evidence for these bioflavonoids is limited. Hesperidin Complex appears possibly ineffective for weight loss and high cholesterol, and there isn't enough reliable evidence to rate it for nonalcoholic fatty liver disease.
Rutin Complex shows insufficient evidence for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-induced respiratory infections, and hemorrhoids. Lemon Bioflavonoid Complex also has insufficient evidence for hay fever, anxiety, high blood pressure, respiratory tract infections, and kidney stones.
In short, if you're taking this product for a specific health goal, the science behind these ingredients for that purpose may be weak or unknown.
How safe is it?
Well-documented data
Hesperidin Complex and Rutin Complex are generally well tolerated in food amounts and short-term supplement use, but long-term safety data are limited. Lemon in food is safe for most people in normal amounts, though concentrated supplements or essential oils haven't been well studied.
One case of allergic skin reaction was reported with topical hesperidin. Rutin may cause headache, flushing, or rashes in some people.
Fresh lemon juice can cause heartburn and stomach discomfort — in one trial, 37% of people taking 60 mL twice daily reported gastrointestinal upset compared to 8% on placebo. For pregnancy: Hesperidin has mixed ratings (Likely Safe and Possibly Safe), but the safety data aren't strong enough to recommend it — the facts advise against supplement use during pregnancy unless your doctor says otherwise.
Rutin is rated Likely Safe in pregnancy but should be avoided in supplement doses unless approved by your doctor. There isn't enough data on Lemon in supplement form during pregnancy, so talk with your doctor or pharmacist for personalized advice.
For breastfeeding: safety data are insufficient for Hesperidin and Rutin, so avoid supplement doses unless your doctor advises otherwise.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you use any blood pressure medication, heart rhythm drugs like verapamil or diltiazem, blood thinners or antiplatelet drugs, diabetes medication, CNS depressants (sleep aids or anti-anxiety medications), antifungal drugs like itraconazole, or any drug that relies on P-glycoprotein transport — the interactions are Moderate to Minor severity and haven't been confirmed in humans, but are worth discussing.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may work best for someone interested in general antioxidant support, though the evidence for specific health claims is weak. If you take any blood pressure medication, blood thinners, heart rhythm drugs, diabetes medication, or antifungal drugs, you'll want to double-check with your doctor or pharmacist before starting — the interactions are theoretical but worth discussing.
Pregnant or breastfeeding women should talk it over with their healthcare provider before use.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bioflavonoids 500 mg, straight from the product label.
| Brand | Nature's Life |
|---|---|
| Net contents | 100 ct |
| Market status | On market |
| Date entered into DSLD | Oct 1, 2012 |
| DSLD ID | 13799 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bioflavonoids 500 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hesperidin Complex | 75 mg | -- |
| Rutin Complex | 75 mg | -- |
| Lemon Bioflavonoid Complex | 500 mg | -- |
Other ingredients: Cellulose, Rose Hips, Acerola juice powder, green pepper, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
PRODUCT DESCRIPTION: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C
Precautions
WARNING: Do not use if safety seal is broken or missing.
Keep out of reach of children.
Keep your licensed health care practitioner informed when using this product.
Suggested/Recommended/Usage/Directions
DIRECTIONS: Use only as directed. Take one (1) tablet up to two times per day with food.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Quality You Can Trust(TM)
Nature's Life(R) guarantees that NO ingredients other than those listed on this label have been added to this product. This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bioflavonoids 500 mg by Nature's Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bioflavonoids 500 mg by Nature's Life
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hesperidin Complex
Interacts with702 drugs
Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...
Hesperidin Complex monograph & interactionsRutin Complex
Interacts with86 drugs
Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...
Rutin Complex monograph & interactionsLemon Bioflavonoid Complex
Interacts with1 drug
Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...
Lemon Bioflavonoid Complex monograph & interactionsOther (inactive) ingredients: Cellulose, Rose Hips, Acerola juice powder, Green pepper, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
Bioflavonoids 500 mg by Nature's Life Drug Interactions
HelloPharmacist Interaction Report
Bioflavonoids 500 mg by Nature's Life contains three active bioflavonoid ingredients, and they do interact with a number of medications.
Hesperidin Complex — the main ingredient — is the source of most interactions and carries Moderate severity concerns across several drug types.
Read the full breakdown — every affected drug type, severity by severity
Hesperidin may add to the sedative effects of CNS depressants (such as sleep aids and anti-anxiety medications), though this has only been seen in animal studies so far. It can theoretically lower blood pressure further if you're already taking blood pressure medication, and it may increase the effects or blood levels of certain heart rhythm drugs — specifically verapamil and diltiazem — while potentially reducing the effectiveness of celiprolol.
There's also a theoretical risk that hesperidin could increase bleeding if combined with blood thinners or antiplatelet drugs like aspirin or warfarin. Additionally, hesperidin may interfere with how your body processes drugs that rely on a particular transport system (P-glycoprotein substrates), though this hasn't been confirmed in humans.
Rutin Complex carries one Moderate interaction: it may lower your blood sugar further if you're taking diabetes medications, based on animal research. Lemon Bioflavonoid Complex has one Minor interaction — it may increase the levels of itraconazole, an antifungal medication, based on a single case report.
Altogether, these interactions span 783 individual medications. Before you start this product, check your exact medications with the search tool on this page, and talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bioflavonoids 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bioflavonoids 500 mg interact with 783 drugs. Click any drug to see the details.
3 of the 3 ingredients in Bioflavonoids 500 mg interact with drugs. Each result below shows which ingredient is responsible. Hesperidin Complex Rutin Complex Lemon Bioflavonoid Complex
AbciximabReoPro
How Abciximab interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
Read the full Hesperidin Complex + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Rutin ComplexAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin Complex + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Read the full Hesperidin Complex + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hesperidin Complex + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Bioflavonoids 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Hesperidin ComplexCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin Complex + Acetaminophen, Meperidine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bioflavonoids 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Hesperidin Complex
Anticoagulant/Antiplatelet Drugs
Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.
Antihypertensive Drugs
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.
Celiprolol (Celicard)
Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.
Cns Depressants
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.
Diltiazem (Cardizem, Others)
Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.
P-Glycoprotein Substrates
Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.
Verapamil (Calan, Others)
Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans
Rutin Complex
Antidiabetes Drugs
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.
Lemon Bioflavonoid Complex
Itraconazole (Sporanox)
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.
Brand information
Manufacturer and brand details for Bioflavonoids 500 mg, from the product label.
Bioflavonoids 500 mg by Nature's Life: Common Questions
Does Bioflavonoids 500 mg by Nature's Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant?
Can I take this while breastfeeding?
Will this help with my cholesterol or weight?
What side effects should I watch for?
Is this product safe for long-term use?
What are bioflavonoids and why are they in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bioflavonoids 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bioflavonoids 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hesperidin
Interacts with 702 drugsHesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...
Read the full Hesperidin monograph → Herb & supplement monographRutin
Interacts with 86 drugsRutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...
Read the full Rutin monograph → Herb & supplement monographLemon
Interacts with 1 drugLemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...
Read the full Lemon monograph →Sources & How We Checked
Bioflavonoids 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hesperidin 14 references
- Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
- Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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