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Dietary supplement

Bioflavonoids 500 mg Ingredients & Drug Interactions

by Nature's Life

Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bioflavonoids 500 mg is a dietary supplement by Nature's Life with 3 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 783 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Complex, Rutin Complex, Lemon Bioflavonoid Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bioflavonoids 500 mg by Nature's Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 3 active bioflavonoid ingredients: Hesperidin Complex, Rutin Complex, and Lemon Bioflavonoid Complex. Bioflavonoids are plant compounds with antioxidant properties found naturally in fruits, vegetables, and citrus.

They're included in supplements for their potential health benefits, though the effectiveness of each for specific conditions varies and isn't always well established. The product also contains several inactive ingredients — cellulose, rose hips, acerola juice powder, green pepper, stearic acid, and silica — which are fillers, binders, and other materials that help form and stabilize the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support for healthy capillaries and circulation.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins, Postoperative swelling, Easy bruising, Fragile capillaries — and 1 related terms.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Varicose veins, Postoperative swelling.
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI), Hemorrhoids, Varicose veins.

The evidence for these bioflavonoids is limited. Hesperidin Complex appears possibly ineffective for weight loss and high cholesterol, and there isn't enough reliable evidence to rate it for nonalcoholic fatty liver disease.

Rutin Complex shows insufficient evidence for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-induced respiratory infections, and hemorrhoids. Lemon Bioflavonoid Complex also has insufficient evidence for hay fever, anxiety, high blood pressure, respiratory tract infections, and kidney stones.

In short, if you're taking this product for a specific health goal, the science behind these ingredients for that purpose may be weak or unknown.

The evidence, ingredient by ingredient Hesperidin Rutin Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin Complex and Rutin Complex are generally well tolerated in food amounts and short-term supplement use, but long-term safety data are limited. Lemon in food is safe for most people in normal amounts, though concentrated supplements or essential oils haven't been well studied.

One case of allergic skin reaction was reported with topical hesperidin. Rutin may cause headache, flushing, or rashes in some people.

Fresh lemon juice can cause heartburn and stomach discomfort — in one trial, 37% of people taking 60 mL twice daily reported gastrointestinal upset compared to 8% on placebo. For pregnancy: Hesperidin has mixed ratings (Likely Safe and Possibly Safe), but the safety data aren't strong enough to recommend it — the facts advise against supplement use during pregnancy unless your doctor says otherwise.

Rutin is rated Likely Safe in pregnancy but should be avoided in supplement doses unless approved by your doctor. There isn't enough data on Lemon in supplement form during pregnancy, so talk with your doctor or pharmacist for personalized advice.

For breastfeeding: safety data are insufficient for Hesperidin and Rutin, so avoid supplement doses unless your doctor advises otherwise.

Side effects, ingredient by ingredient Hesperidin Rutin Lemon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Rutin, Lemon, Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 783 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use any blood pressure medication, heart rhythm drugs like verapamil or diltiazem, blood thinners or antiplatelet drugs, diabetes medication, CNS depressants (sleep aids or anti-anxiety medications), antifungal drugs like itraconazole, or any drug that relies on P-glycoprotein transport — the interactions are Moderate to Minor severity and haven't been confirmed in humans, but are worth discussing.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work best for someone interested in general antioxidant support, though the evidence for specific health claims is weak. If you take any blood pressure medication, blood thinners, heart rhythm drugs, diabetes medication, or antifungal drugs, you'll want to double-check with your doctor or pharmacist before starting — the interactions are theoretical but worth discussing.

Pregnant or breastfeeding women should talk it over with their healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bioflavonoids 500 mg, straight from the product label.

Brand Nature's Life
Net contents 100 ct
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 13799
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bioflavonoids 500 mg by Nature's Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Hesperidin Complex75 mg--
Rutin Complex75 mg--
Lemon Bioflavonoid Complex500 mg--

Other ingredients: Cellulose, Rose Hips, Acerola juice powder, green pepper, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

PRODUCT DESCRIPTION: Bioflavonoids act as an antioxidant. They are intended to provide nutritive support for normal, healthy capillaries and the proper absorption and use of Vitamin C

Precautions

WARNING: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Use only as directed. Take one (1) tablet up to two times per day with food.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Quality You Can Trust(TM)

Nature's Life(R) guarantees that NO ingredients other than those listed on this label have been added to this product. This quality Nature's Life product meets our Quality Assurance Procedures and Good Manufacturing Practices.

See for yourself

Bioflavonoids 500 mg by Nature's Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bioflavonoids 500 mg by Nature's Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hesperidin Complex

Interacts with
702 drugs
75 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Complex monograph & interactions

Rutin Complex

Interacts with
86 drugs
75 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin Complex monograph & interactions

Lemon Bioflavonoid Complex

Interacts with
1 drug
500 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Lemon Bioflavonoid Complex monograph & interactions

Other (inactive) ingredients: Cellulose, Rose Hips, Acerola juice powder, Green pepper, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bioflavonoids 500 mg by Nature's Life Drug Interactions

Want to check YOUR meds against Bioflavonoids 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
783Drugs
783 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Bioflavonoids 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin Complex7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D

Rutin Complex1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D

Lemon Bioflavonoid Complex1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Bioflavonoids 500 mg, from the product label.

Nature's Life

See all Nature's Life products
Name
NutraPure, Inc.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Bioflavonoids 500 mg by Nature's Life: Common Questions

Does Bioflavonoids 500 mg by Nature's Life interact with any medications?
Yes. Based on its ingredients, Bioflavonoids 500 mg has a known interaction with 783 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bioflavonoids 500 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data for these bioflavonoids in pregnancy aren't strong enough to recommend them — the facts advise against supplement use during pregnancy unless your doctor approves. Talk with your doctor or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
Safety data during breastfeeding are insufficient or unknown for these ingredients, so supplement doses should be avoided unless your doctor advises otherwise. Check with your doctor or pharmacist for guidance.
Will this help with my cholesterol or weight?
Hesperidin appears possibly ineffective for cholesterol and weight loss based on available evidence. The other ingredients don't have established effectiveness for those goals either.
What side effects should I watch for?
Rutin may cause headache, flushing, or rashes. Fresh lemon can trigger heartburn and stomach discomfort, especially in larger amounts. One case of allergic skin reaction was reported with topical hesperidin. Most people tolerate these ingredients well in food and short-term use.
Is this product safe for long-term use?
These bioflavonoids are generally well tolerated in food amounts and short-term supplement use, but high-quality long-term safety data are limited. If you plan to take this regularly, discuss it with your doctor or pharmacist.
What are bioflavonoids and why are they in this product?
Bioflavonoids are plant compounds with antioxidant properties found naturally in fruits, citrus, and vegetables. They're included in supplements for their potential health benefits, though the evidence for specific uses is often weak or not well established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bioflavonoids 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bioflavonoids 500 mg label
Sources

Sources & How We Checked

Bioflavonoids 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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