Digest Ingredients & Drug Interactions
by TransFormation Professional Protocol
What is this page for?
First and foremost: checking Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digest is a dietary supplement by TransFormation Professional Protocol with 15 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digest by TransFormation Professional Protocol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Digest contains 15 active ingredients, all digestive enzymes that break down different components of food. Protease breaks down proteins; lipase handles fats; lactase digests lactose (milk sugar); and the others target starches, fiber, and other carbohydrates.
You'll also find amylase, cellulase, peptidase, glucoamylase, pectinase, beta-glucanase, phytase, invertase, hemicellulase, diastase, and alpha-galactosidase, plus two proprietary enzyme blends listed as Tzyme Protease Blend and Tzyme Polysaccharolytic Blend. The capsule itself contains hypromellose (a plant-based capsule material), water, and calcium citrate as inactive ingredients — no fillers beyond those.
Does it work?
Strong evidence
The data we hold shows that lactase is effective for lactose intolerance. For the other enzymes — protease, lipase, and phytase — the evidence for conditions like inflammatory bowel disease, indigestion (dyspepsia), iron or zinc deficiency, and skin aging is insufficient to rate them.
We don't have effectiveness ratings on file for amylase, cellulase, peptidase, glucoamylase, pectinase, beta-glucanase, invertase, hemicellulase, diastase, or alpha-galactosidase.
How safe is it?
Well-documented data
Protease is generally well tolerated but may cause digestive upset or allergic reactions in some people; it should be avoided during pregnancy unless prescribed, and has little safety data in breastfeeding. Lipase is generally well tolerated in supplement form, though people with serious digestive conditions should use it only under medical guidance; there's little safety data in pregnancy or breastfeeding, so check with your doctor.
Lactase is generally well tolerated and likely safe in pregnancy; it acts only in the gut, so limited breastfeeding data applies. Phytase is considered low-risk in foods but has limited human supplement data; there isn't enough safety information for pregnancy, so avoid unless advised by your doctor, and breastfeeding safety is not well studied.
Rare allergic reactions to powdered forms of protease, lactase, and phytase have been reported, mostly in occupational settings. We don't have safety data on file for amylase, cellulase, peptidase, glucoamylase, pectinase, beta-glucanase, invertase, hemicellulase, diastase, or alpha-galactosidase.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we have no monograph data for several of the enzymes in this product.
Check your exact medications with the search tool on this page, and if anything comes up or you have questions, ask your doctor or pharmacist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Digest is a digestive enzyme blend that may help if you have trouble breaking down food or digest dairy; lactase in particular is established for lactose intolerance. If you're pregnant, breastfeeding, or have serious digestive conditions, talk with your doctor or pharmacist first — some ingredients have limited safety data in those situations.
Run your medications through the checker on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digest, straight from the product label.
| Brand | TransFormation Professional Protocol |
|---|---|
| Barcode (UPC) | 632889400338 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 288508 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digest by TransFormation Professional Protocol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 24 mg | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Tzyme Protease Blend | 67 mg | -- |
| Tzyme Polysaccharolytic Blend | 302 mg | -- |
| Macerase | 0 NP | -- |
Other ingredients: Hypromellose, Water, Calcium Citrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Optimal digestion is dependent upon effective digestive enzymes.
No unnecessary ingredients
Formula
TPP Digest includes highly active enzymes with a broad range of specificities to handle all food preferences.
This proprietary blend of highly active, functional, pH balanced, and GI tract stable enzymes is formulated to enhance the digestive process and impart systemic benefits.
General Statements
All Transformation Enzyme formulas are carefully prepared to assured maximum quality and nutritional effectiveness.
Enzyme activity is measured in Food Chemicals Codex (FCC) units.
Suggested/Recommended/Usage/Directions
Recommended usage: One (1) capsule with every meal or snack with at least 8 oz. of liquid or as directed by a health care practitioner. Contents may be removed from capsule and taken by spoon immediately after mixing with a small amount of tepid water.
Storage
Store tightly sealed in a cool, dry place.
Precautions
Keep out of reach of children.
Brand IP Statement(s)
Tzyme is a trademark of Transformation Enzyme Corporation (TEC).
Transformation Enzyme is a registered trademark of TEC. Professional Protocol is a trademark of TEC.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Enzyme Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digest by TransFormation Professional Protocol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digest by TransFormation Professional Protocol
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsTzyme Protease Blend
- › Protease
- › Peptidase
Other (inactive) ingredients: Hypromellose, Water, Calcium Citrate. These complete the product’s ingredient list but are not active constituents.
Digest by TransFormation Professional Protocol Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digest, from the product label.
TransFormation Professional Protocol
See all TransFormation Professional Protocol products- Name
- Transformation Enzyme Corporation
- Street Address
- 2900 Wilcrest Dr. Suite 220
- City
- Houston
- State
- TX
- ZipCode
- 77042
Digest by TransFormation Professional Protocol: Common Questions
Does Digest by TransFormation Professional Protocol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is lactase really effective for lactose intolerance?
Can I take this if I'm pregnant?
Are there any enzymes in this that actually work for digestion problems?
What's the difference between protease, lipase, and amylase?
Can this cause allergic reactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC