Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Protease Ingredients & Drug Interactions

by TransFormation Professional Protocol

Protease label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Protease against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Protease is a dietary supplement by TransFormation Professional Protocol with 2 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Protease by TransFormation Professional Protocol

Ask about any prescription or over-the-counter medication and we check it for interactions with Protease by TransFormation Professional Protocol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Protease by TransFormation Professional Protocol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Tzyme Protease Blend” is a proprietary blend — the label gives one combined amount (492 mg) without saying how much of each component you get.

This product has two active ingredients: bromelain and peptidase. Bromelain is an enzyme extracted from pineapple that's used to support protein digestion and has been studied for various inflammatory and immune responses.

The second active ingredient, peptidase, breaks down proteins as well — though we hold no interaction data for it. The capsules also contain inactive ingredients (hypromellose, water, and calcium citrate) that serve as the capsule shell and filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bromelain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy blood rheology.
  • We looked for evidence on: Chronic venous insufficiency, Venous leg ulcers, Blood flow, Fibrin metabolism.
  • The closest evidence on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (Natural Medicines).
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Venous leg ulcers.

The evidence for bromelain's effectiveness in the conditions listed — hay fever, burns, cancer support, nerve damage from chemotherapy, vein health, and diabetes — is insufficient to rate. That means human studies are either too small, too few, or too varied to draw a clear conclusion about whether it actually works for these uses.

The data we hold doesn't establish how well this product performs for its intended purpose.

The evidence, ingredient by ingredient Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated in the short term, but long-term safety data is limited — so we don't know what happens if you take it for months or years. The most common side effects when taken by mouth are diarrhea, flatulence, stomach upset, and headache.

Some people may have allergic reactions, especially if they're allergic to pineapple; inhaling bromelain (occupationally) can trigger asthma, throat itching, eye irritation, and other allergic symptoms. During pregnancy, there isn't enough safety data — the facts advise against it.

The same goes for breastfeeding: safety is unknown, so it's best avoided.

Side effects, ingredient by ingredient Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs (warfarin, apixaban, aspirin, clopidogrel, and others), this product may increase your bleeding risk — check with your pharmacist first. Tetracycline antibiotics may have increased absorption, though human data is mixed.

Always verify your exact medications with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This protease enzyme product may help with protein digestion, but the evidence for specific health claims is incomplete. If you take blood thinners, antiplatelet drugs, or tetracycline antibiotics, talk with your pharmacist before starting it — the interaction with blood thinners is the main concern.

Those who are pregnant, breastfeeding, or allergic to pineapple should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Protease, straight from the product label.

Brand TransFormation Professional Protocol
Barcode (UPC) 632889400819
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 288515
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Protease by TransFormation Professional Protocol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
632889400819
IngredientAmount% DV
Bromelain0 NP--
Peptidase0 NP--
Tzyme Protease Blend492 mg--

Other ingredients: Hypromellose, Water, Calcium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

TTP Protease is a unique proteolytic enzyme blend that supports healthy blood rheology.

Tzyme is a trademark of Transformation Enzyme Corporation (TEC). This proprietary blend of highly active, functional, pH balanced, and GI tract stable enzymes is formulated to enhance the digestive process and impart systemic benefits.

Formulation

No unnecessary ingredients

Enzyme activity is measured in Food Chemicals Codex (FCC) units.

All Transformation Enzyme formulas are carefully prepared to assure maximum quality and nutritional effectiveness.

Suggested/Recommended/Usage/Directions

Recommended Usage: One (1) capsule two times a day on an empty stomach with 8 oz. of water or as directed by a health care practitioner. Contents may be removed from capsule and taken by spoon immediately after mixing with a small amount of tepid water. One (1) capsule may be taken with meals to enhance the digestion of proteins.

Storage

Store tightly sealed in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Enzyme Supplement

Brand IP Statement(s)

Tzyme is a trademark of Transformation Enzyme Corporation (TEC). This proprietary blend of highly active, functional, pH balanced, and GI tract stable enzymes is formulated to enhance the digestive process and impart systemic benefits.

Transformation Enzyme is a registered trademark of TEC. Professional Protocol is a trademark of TEC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Protease by TransFormation Professional Protocol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Protease label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Protease by TransFormation Professional Protocol

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tzyme Protease Blend

492 mg per serving

Other (inactive) ingredients: Hypromellose, Water, Calcium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Protease by TransFormation Professional Protocol Drug Interactions

Want to check YOUR meds against Protease?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Individual Drug Interactions

The ingredients in Protease interact with 141 drugs. Click any drug to see the details.

1 of the 2 ingredients in Protease interact with drugs. Each result below shows which ingredient is responsible. Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Protease with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Protease, from the product label.

TransFormation Professional Protocol

See all TransFormation Professional Protocol products
Name
Transformation Enzyme Corp.
Street Address
2900 Wilcrest Dr. Suite 220
City
Houston
State
TX
ZipCode
77042
Pharmacist Counseling Corner

Protease by TransFormation Professional Protocol: Common Questions

Does Protease by TransFormation Professional Protocol interact with any medications?
Yes. Based on its ingredients, Protease has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Protease contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is bromelain and what does it do?
Bromelain is an enzyme from pineapple that breaks down proteins. It's included in digestive enzyme products because it may support protein digestion and has been studied for inflammation and immune responses, though the evidence for specific health claims is still unclear.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data for bromelain in pregnancy, so it's best avoided. Safety while breastfeeding is also unknown, so avoid it then too. Talk with your doctor or pharmacist if you have questions about alternatives.
What are the most common side effects?
When taken by mouth, bromelain most often causes diarrhea, gas, stomach upset, and headache. Some people may experience allergic reactions, especially if they're sensitive to pineapple.
Will this work for hay fever or burns?
The evidence for bromelain in hay fever, burns, and other conditions listed on this product is insufficient to rate — meaning human studies haven't been conclusive enough to confirm whether it works or how well.
Is this safe to take long-term?
Bromelain is generally well tolerated in the short term, but evidence on long-term safety is limited. We don't have enough data to say how safe it is if you take it for months or longer — talk with your pharmacist about your situation.
Why does this product have two protease ingredients?
Bromelain and peptidase are both enzymes that break down proteins. Using more than one may provide complementary digestive support, though we hold no interaction data for peptidase to evaluate it separately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Protease label
Go deeper

The Full Monographs Behind Protease’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

Protease's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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