Interactions on record — worth a quick check against your medications. Based on 5 of 15 ingredients. Check your meds →
Dietary supplement

Digestion Enhancement Enzymes Ingredients & Drug Interactions

by HealthForce SuperFoods

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Digestion Enhancement Enzymes is a dietary supplement by HealthForce SuperFoods with 15 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Digestion Enhancement Enzymes by HealthForce SuperFoods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 15 active ingredients.
  • “Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (1,300 mg) without saying how much of each component you get.

This product contains 15 active digestive enzymes, each designed to help break down different components of food. Amylase works on carbohydrates, lipase on fats, and proteases (including papain and bromelain) on proteins.

Lactase breaks down milk sugar for people with lactose intolerance. The blend also includes cellulase, peptidase, invertase, glucoamylase, alpha-galactosidase, xylanase, pectinase, acid protease, and hemicellulase—a broad spectrum meant to support digestion of complex foods.

The inactive ingredients are MCT oil, tapioca starch, and hypromellose (a capsule component).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support digestion and nutrient assimilation.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Lactose intolerance, Postoperative pain, Postoperative swelling, Rhinosinusitis — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The data we hold shows that lactase—one ingredient in this blend—is effective for lactose intolerance. For the other active ingredients and their purported digestive roles, the evidence isn't established in our database; we have insufficient reliable evidence to rate bromelain for burns or allergies, papain for radiation dermatitis or muscle soreness, and lipase for inflammatory bowel disease or dyspepsia.

No effectiveness data exists on file for the remaining enzymes.

The evidence, ingredient by ingredient Papain Bromelain Lipase Lactase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food, but supplements may irritate the digestive tract or trigger allergic reactions—itching, watery eyes, sneezing, abdominal cramps, or diarrhea in sensitive people. High doses are unsafe and carry a rare risk of severe inflammation or perforation of the esophagus.

Bromelain is well tolerated short-term but may cause diarrhea, gas, stomach upset, or headache; long-term safety data is limited. Allergic reactions are possible with bromelain too.

Lipase and lactase are generally well tolerated; lactase has rare reports of contact allergy in workers. Acid protease and proteases may cause digestive upset or allergic reactions, though they're well tolerated in most adults.

If you work with or inhale enzyme powders, occupational exposure to airborne particles can trigger respiratory allergies—rhinitis, sneezing, wheezing, or asthma.

Side effects, ingredient by ingredient Papain Bromelain Lipase Lactase Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on warfarin (Coumadin) or any other blood thinner or antiplatelet drug—papain and bromelain may increase bleeding risk (moderate severity). If you take a tetracycline antibiotic, check with your pharmacist about bromelain's minor interaction with absorption.

For ingredients we could not check—amylase, cellulase, peptidase, invertase, glucoamylase, alpha-galactosidase, xylanase, pectinase, and hemicellulase—no interactions are documented in our data, but that's not a guarantee none exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people looking for digestive enzyme support, especially those with lactose intolerance (where lactase is effective) or who feel they need help breaking down food. If you take warfarin or any blood thinner, talk to your pharmacist before starting it—papain and bromelain both carry moderate interaction risks.

Anyone with serious digestive conditions or on tetracycline antibiotics should also check first. Call your pharmacist or doctor if you develop itching, stomach pain, allergic symptoms, or unusual bruising.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestion Enhancement Enzymes, straight from the product label.

Brand HealthForce SuperFoods
Barcode (UPC) 650786000017
Net contents 120 VeganCap(s)(TM)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 293431
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestion Enhancement Enzymes by HealthForce SuperFoods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegan Cap(s)
Maximum serving Sizes:
4 Vegan Cap(s)
Servings per container
30
UPC/BARCODE
650786000017
IngredientAmount% DV
Amylase0 NP--
Papain0 NP--
Bromelain0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Acid Protease0 NP--
Proteases0 NP--
Hemicellulase0 NP--
Digestive Enzyme Blend1300 mg--

Other ingredients: MCT Oil, Tapioca Starch, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestion Enhancement Enzymes offers a full-spectrum and comprehensive blend of 15 different vegan, plant-sourced enzymes designed to help support digestion and assimilation of all types of foods and nutrients.

OU Pareve (Kosher)

Formulation

Digestion Enhancement Enzymes offers a full-spectrum and comprehensive blend of 15 different vegan, plant-sourced enzymes designed to help support digestion and assimilation of all types of foods and nutrients.

Free of fillers and harmful excipients.

Certified Vegan Vegan.org

Suggested/Recommended/Usage/Directions

Suggested use: 2–4 capsules per meal or snack, depending on content and volume of meal. Ideally, take with the first bites of a meal/snack.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not designed to diagnose, treat, cure, or prevent any disease.

Precautions

This product is only intended for use by individuals with already healthy digestive systems.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Certified Vegan Vegan.org OU Pareve (Kosher)

See for yourself

Digestion Enhancement Enzymes by HealthForce SuperFoods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestion Enhancement Enzymes by HealthForce SuperFoods

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegan Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Digestive Enzyme Blend

1300 mg per serving

Other (inactive) ingredients: MCT Oil, Tapioca Starch, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestion Enhancement Enzymes by HealthForce SuperFoods Drug Interactions

Want to check YOUR meds against Digestion Enhancement Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestion Enhancement Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Digestion Enhancement Enzymes, from the product label.

HealthForce SuperFoods

See all HealthForce SuperFoods products
Name
Excelsior Alchemy
City
Tempe
State
AZ
ZipCode
85284
Phone Number
(800) 748-6229
Web Address
www.healthforcesuperfoods.com
Pharmacist Counseling Corner

Digestion Enhancement Enzymes by HealthForce SuperFoods: Common Questions

Does Digestion Enhancement Enzymes by HealthForce SuperFoods interact with any medications?
Yes. Based on its ingredients, Digestion Enhancement Enzymes has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestion Enhancement Enzymes contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No—papain and bromelain are best avoided in pregnancy due to safety concerns. Lipase, lactase, and the proteases all have little safety data during pregnancy, so talk with your doctor before taking this product while pregnant. Only use if your doctor advises it.
Is it safe while breastfeeding?
There isn't enough safety data for most of these enzymes while breastfeeding. Papain, bromelain, lipase, acid protease, and proteases all have limited or absent information, so check with your doctor or pharmacist first. Lactase's safety during breastfeeding hasn't been well studied either.
What are papain and bromelain?
Papain is a protein-digesting enzyme from papaya; bromelain is the same type of enzyme from pineapple. Both break down proteins in food to aid digestion.
Will this help with gas and bloating?
We don't have effectiveness data for this product on gas or bloating. The enzymes are meant to break down different food components, but we can't confirm from our data whether they actually relieve those symptoms.
Can I use this if I take tetracycline antibiotics?
Bromelain may theoretically increase how much tetracycline your body absorbs, though one study in healthy people found no real change. Still, check with your pharmacist—they can tell you if your specific antibiotic is a concern.
What are the most common side effects?
The most common reported effects are diarrhea, gas, and stomach upset from bromelain, and allergic reactions (itching, sneezing, watery eyes, abdominal cramps) from papain in sensitive people. High doses of papain carry a rare risk of serious inflammation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestion Enhancement Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestion Enhancement Enzymes label
Go deeper

The Full Monographs Behind Digestion Enhancement Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Digestion Enhancement Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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