Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Digestive Enzyme Essentials With Pancreatin Ingredients & Drug Interactions

by Martin Avenue Pharmacy

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Digestive Enzyme Essentials With Pancreatin is a dietary supplement by Martin Avenue Pharmacy with 8 active ingredients. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 142 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “L-Lysine” is listed as a grouped ingredient — the label gives one combined amount (80 mg) without saying how much of each component you get.
  • “Pancreatin (4X) USP” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This tablet contains 8 active ingredients: digestive enzymes (amylase, protease, lipase, cellulase, pepsin, and pancreatin) that help break down food; the amino acid L-lysine; and ox bile extract to aid fat digestion. The pancreatin is labeled 4X USP potency, meaning it's concentrated.

Inactive ingredients — cellulose, vegetable stearate, and silica — are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Pancreatic insufficiency, Bloating — and 1 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Postoperative swelling, Postoperative pain.

The evidence for most of these ingredients is limited. L-lysine is possibly effective for cold sores (herpes labialis), but there isn't enough reliable evidence to rate its use for growth support, pressure ulcers, or diabetic foot ulcers.

For lipase and bromelain, the evidence isn't established in our data — there's insufficient reliable evidence for their use in inflammatory bowel disease, dyspepsia, hay fever, burns, or diabetes. The effectiveness of the other enzymes (amylase, protease, cellulase, pepsin) and pancreatin as a digestive aid isn't rated in the data we hold.

The evidence, ingredient by ingredient Lysine Proteolytic Enzymes (proteases) Lipase Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-lysine is generally well tolerated at typical doses, though high amounts may cause stomach upset (abdominal pain, diarrhea, indigestion), and long-term safety isn't well studied. Bromelain is generally well tolerated short-term but may cause diarrhea, gas, stomach upset, or headache; long-term evidence is limited.

Protease and pepsin (both proteolytic enzymes) may cause digestive upset or allergic reactions, and rarely, airborne occupational exposure to pepsin has triggered allergic rhinitis or asthma. Lipase has no reported adverse effects in adults, though safety hasn't been thoroughly evaluated.

For pregnancy: Lysine supplement safety isn't well studied, so check with your doctor first. Bromelain should be avoided — there isn't enough safety data.

Protease and pepsin are best avoided in pregnancy unless prescribed. Lipase has limited pregnancy data, so use only if your doctor advises it.

For breastfeeding: there isn't enough reliable information on any of these ingredients, so caution is advised — talk with your healthcare provider before use.

Side effects, ingredient by ingredient Lysine Proteolytic Enzymes (proteases) Lipase Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Lysine, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 142 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — bromelain may increase bleeding risk. Tetracycline antibiotics may interact as well.

If you take 5-HT4 agonist medications for digestive conditions, L-lysine may reduce their effects. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a digestive enzyme blend that may help with digestion, though evidence for most ingredients is limited or not established. If you take blood thinners, tetracycline antibiotics, or certain digestive medications, you need to check with your doctor or pharmacist before starting it.

Pregnant or breastfeeding individuals should talk with their healthcare provider first, as safety data is sparse. Discuss this product with your own doctor or pharmacist to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzyme Essentials With Pancreatin, straight from the product label.

Brand Martin Avenue Pharmacy
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 19077
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
IngredientAmount% DV
L-Lysine Hydrochloride100 mg--
Amylase25000 USP Unit(s)--
Protease25000 USP Unit(s)--
Lipase2000 USP Unit(s)--
L-Lysine80 mg--
Cellulase6 W.C.A. Unit(s)--
Pepsin66 mg--
Ox Bile extract100 mg--
Bromelain300 MCU--
Pancreatin (4X) USP1000 mg--

Other ingredients: Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

"We Make It Better..."

QUALITY AND POTENCY GUARANTEED

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 or 2 tablets daily at mealtime or as directed by physician.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is broken.

Storage

For optimal storage conditions, store in a cool, dry place. (59-77degF/15-25degC) (35-65% relative humidity)

General

#10047

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

AccuDisin(R) is a trade name for rapid disintegrating control release.

See for yourself

Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Lysine

Interacts with
1 drug
80 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine monograph & interactions

Cellulase

6 W.C.A. Unit(s) per serving

Pepsin

No known
interactions
66 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Ox Bile extract

100 mg per serving

Pancreatin (4X) USP

1000 mg per serving

Other (inactive) ingredients: Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy Drug Interactions

Want to check YOUR meds against Digestive Enzyme Essentials With Pancreatin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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142Drugs
122 Moderate 20 Minor

Ingredients driving the most interactions

Bromelain 141

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzyme Essentials With Pancreatin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Digestive Enzyme Essentials With Pancreatin, from the product label.

Martin Avenue Pharmacy

See all Martin Avenue Pharmacy products
Name
Martin Avenue Pharmacy, Inc.
City
Naperville
State
IL
ZipCode
60540
Phone Number
(630) 355-6400
Pharmacist Counseling Corner

Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy: Common Questions

Does Digestive Enzyme Essentials With Pancreatin by Martin Avenue Pharmacy interact with any medications?
Yes. Based on its ingredients, Digestive Enzyme Essentials With Pancreatin has a known interaction with 142 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzyme Essentials With Pancreatin contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Not all ingredients have been studied in pregnancy. L-lysine, protease, pepsin, and lipase have insufficient safety data — some (bromelain, protease, pepsin) advise against use. Talk with your doctor before starting, as pregnancy safety is individual and depends on which ingredients concern you most.
Can I take this while breastfeeding?
Safety data while breastfeeding is very limited for all the active ingredients in this product. There isn't enough reliable information to know either way, so caution is advised. Check with your healthcare provider first.
Does L-lysine in this product help with cold sores?
L-lysine is possibly effective for cold sores (herpes labialis) based on the evidence we have. That said, the dose in this product and how it's formulated may matter, so talk with your pharmacist about whether this product is the right choice for that purpose.
What are the common side effects?
L-lysine may cause abdominal pain, diarrhea, or indigestion, especially at high doses. Bromelain may cause diarrhea, gas, stomach upset, or headache. The enzymes may cause digestive upset. Allergic reactions are rare but possible, especially to protease or pepsin.
Is this product safe for someone with a serious digestive condition?
People with serious digestive conditions should use lipase (and the other enzymes in this product) only under medical guidance. Talk with your doctor before starting, especially if you have inflammatory bowel disease or another chronic condition.
Does this product have any fillers?
Yes. The inactive ingredients are cellulose, vegetable stearate, and silica, which serve as fillers and binders to hold the tablet together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzyme Essentials With Pancreatin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzyme Essentials With Pancreatin label
Sources

Sources & How We Checked

Digestive Enzyme Essentials With Pancreatin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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