Digestive Support Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Digestive Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Support is a dietary supplement by Bariatric Fusion with 8 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis DE-111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digestive Support by Bariatric Fusion
Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Support by Bariatric Fusion — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Digestive Support by Bariatric Fusion
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This capsule contains 8 active digestive enzymes and a probiotic. You're getting protease, lactase, peptidase, glucoamylase, alpha-galactosidase, acid maltase, and the live probiotic Bacillus subtilis DE-111 — all designed to help break down food and support your digestive tract.
The inactive ingredients (rice maltodextrin, hypromellose, water, and medium chain triglyceride) are there to hold everything together in capsule form.
Does it work?
Strong evidence
Lactase in this product is effective for lactose intolerance, helping people digest milk and dairy. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea — the kind that sometimes happens when antibiotics wipe out your good gut bacteria.
For the other conditions these strains are studied for — constipation, colic, athletic performance, eczema, and diabetes — the evidence isn't established in the data we hold.
How safe is it?
Well-documented data
Protease and lactase are generally well tolerated in adults, though protease can rarely cause digestive upset or allergic reactions; occupational exposure to airborne protease has occasionally triggered asthma or rhinitis. Bacillus subtilis is generally well tolerated in healthy adults, though one trial participant reported a headache.
Rare cases of diarrhea have been reported with B. subtilis, and there are historical case reports of serious infection (bacteremia and meningitis) linked to very high consumption of natto in people with serious underlying health conditions. For pregnancy: protease safety isn't established — avoid it unless your doctor prescribes it.
Lactase is likely safe in pregnancy, though check with your doctor first. Bacillus subtilis hasn't enough safety data in pregnancy — talk with your doctor.
For breastfeeding: protease and B. subtilis have limited data — ask your doctor or pharmacist first. Lactase acts only in your gut, but ask before regular use.
Meds to double-check
Moderate interaction found
Double-check antibiotic drugs before you take this product. Antibiotics may reduce how well the Bacillus subtilis probiotic in it works.
Space them out by a few hours if you can.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is aimed at people who need extra digestive support, especially those managing lactose intolerance or recovering from antibiotic use. If you take antibiotics, space them out from this supplement.
Pregnant or breastfeeding? Check with your doctor or pharmacist before starting — there isn't enough safety data for all ingredients to give a clear yes or no.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Support, straight from the product label.
| Brand | Bariatric Fusion |
|---|---|
| Barcode (UPC) | 810030380894 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 317894 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Support by Bariatric Fusion, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lactase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Bacillus subtilis DE-111 | 3.3 mg | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Acid Maltase | 0 NP | -- |
| BioCore Optimum Complete | 110 mg | -- |
Other ingredients: Rice Maltodextrin, Hypromellose, Water, Medium Chain Triglyceride
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Digestive enzymes + probiotics
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
Copyright 2022 Bariatric Fusion
BioCore and DE111 are registered trademarks of Deerland Probiotics & Enzymes, Inc.
Suggested/Recommended/Usage/Directions
Directions: Take 1 capsule with a meal or as prescribed by your healthcare professional.
Precautions
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Support by Bariatric Fusion label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Support by Bariatric Fusion
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Bacillus subtilis DE-111
Interacts with182 drugs
Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...
Bacillus subtilis DE-111 monograph & interactionsOther (inactive) ingredients: Rice Maltodextrin, Hypromellose, Water, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.
Digestive Support by Bariatric Fusion Drug Interactions
HelloPharmacist Interaction Report
Digestive Support by Bariatric Fusion has one documented interaction we need to flag: Bacillus subtilis, a live probiotic strain in this product, may reduce the effectiveness of antibiotic drugs.
Because the supplement contains living organisms, antibiotics can kill them off, which means the probiotic won't work as intended. The solution is straightforward — space out your antibiotic and this supplement by a few hours.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 182 individual medications.
The other active ingredients in this product — protease, lactase, peptidase, glucoamylase, alpha-galactosidase, and acid maltase — either have no documented interactions in our data or we haven't yet checked them. We couldn't verify interaction data for amylase, peptidase, glucoamylase, alpha-galactosidase, and acid maltase.
Use the medication checker below to confirm your specific prescriptions and over-the-counter drugs aren't affected before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Digestive Support?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digestive Support interact with 182 drugs. Click any drug to see the details.
1 of the 8 ingredients in Digestive Support interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis DE-111
Vonoprazan, AmoxicillinVoquezna Dual
How Vonoprazan, Amoxicillin interacts with Digestive Support — through 1 ingredient. Tap an ingredient for the detail:
Bacillus Subtilis De-111Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis De-111 + Vonoprazan, Amoxicillin interactionVonoprazan, Amoxicillin, ClarithromycinVoquezna Triple
How Vonoprazan, Amoxicillin, Clarithromycin interacts with Digestive Support — through 1 ingredient. Tap an ingredient for the detail:
Bacillus Subtilis De-111Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis De-111 + Vonoprazan, Amoxicillin, Clarithromycin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digestive Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bacillus subtilis DE-111
Antibiotic Drugs
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.
Brand information
Manufacturer and brand details for Digestive Support, from the product label.
Bariatric Fusion
See all Bariatric Fusion products- Name
- Bariatric Fusion
- Street Address
- 2741 Transit Rd.
- City
- Elma
- State
- NY
- ZipCode
- 14059
- Phone Number
- 1.866.259.0602
- Web Address
- Bariatricfusion.com
Digestive Support by Bariatric Fusion: Common Questions
Does Digestive Support by Bariatric Fusion interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this help with lactose intolerance?
Can I take this if I'm on antibiotics?
Will this help with antibiotic-induced diarrhea?
Is this safe during pregnancy?
What does protease do?
Can I take this if I'm breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Support is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Support’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bacillus Subtilis
Interacts with 182 drugsBacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...
Read the full Bacillus Subtilis monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Digestive Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Bacillus Subtilis 10 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
- La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
- Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
- Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
- Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
- Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
- Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
- Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
- Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC