Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Digestive Support Ingredients & Drug Interactions

by Bariatric Fusion

Digestive Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Support is a dietary supplement by Bariatric Fusion with 8 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis DE-111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Support by Bariatric Fusion

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Support by Bariatric Fusion — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Support by Bariatric Fusion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “BioCore Optimum Complete” is listed as a grouped ingredient — the label gives one combined amount (110 mg) without saying how much of each component you get.

This capsule contains 8 active digestive enzymes and a probiotic. You're getting protease, lactase, peptidase, glucoamylase, alpha-galactosidase, acid maltase, and the live probiotic Bacillus subtilis DE-111 — all designed to help break down food and support your digestive tract.

The inactive ingredients (rice maltodextrin, hypromellose, water, and medium chain triglyceride) are there to hold everything together in capsule form.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support with enzymes and probiotics.
  • We looked for evidence on: Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Lactose intolerance, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence, and more.

Lactase in this product is effective for lactose intolerance, helping people digest milk and dairy. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea — the kind that sometimes happens when antibiotics wipe out your good gut bacteria.

For the other conditions these strains are studied for — constipation, colic, athletic performance, eczema, and diabetes — the evidence isn't established in the data we hold.

The evidence, ingredient by ingredient Bacillus Subtilis Proteolytic Enzymes (proteases) Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lactase are generally well tolerated in adults, though protease can rarely cause digestive upset or allergic reactions; occupational exposure to airborne protease has occasionally triggered asthma or rhinitis. Bacillus subtilis is generally well tolerated in healthy adults, though one trial participant reported a headache.

Rare cases of diarrhea have been reported with B. subtilis, and there are historical case reports of serious infection (bacteremia and meningitis) linked to very high consumption of natto in people with serious underlying health conditions. For pregnancy: protease safety isn't established — avoid it unless your doctor prescribes it.

Lactase is likely safe in pregnancy, though check with your doctor first. Bacillus subtilis hasn't enough safety data in pregnancy — talk with your doctor.

For breastfeeding: protease and B. subtilis have limited data — ask your doctor or pharmacist first. Lactase acts only in your gut, but ask before regular use.

Side effects, ingredient by ingredient Bacillus Subtilis Proteolytic Enzymes (proteases) Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check antibiotic drugs before you take this product. Antibiotics may reduce how well the Bacillus subtilis probiotic in it works.

Space them out by a few hours if you can.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people who need extra digestive support, especially those managing lactose intolerance or recovering from antibiotic use. If you take antibiotics, space them out from this supplement.

Pregnant or breastfeeding? Check with your doctor or pharmacist before starting — there isn't enough safety data for all ingredients to give a clear yes or no.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Support, straight from the product label.

Brand Bariatric Fusion
Barcode (UPC) 810030380894
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 317894
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Support by Bariatric Fusion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
810030380894
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lactase0 NP--
Peptidase0 NP--
Glucoamylase0 NP--
Bacillus subtilis DE-1113.3 mg--
Alpha-Galactosidase0 NP--
Acid Maltase0 NP--
BioCore Optimum Complete110 mg--

Other ingredients: Rice Maltodextrin, Hypromellose, Water, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestive enzymes + probiotics

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2022 Bariatric Fusion

BioCore and DE111 are registered trademarks of Deerland Probiotics & Enzymes, Inc.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule with a meal or as prescribed by your healthcare professional.

Precautions

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Support by Bariatric Fusion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Support by Bariatric Fusion

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus subtilis DE-111

Interacts with
182 drugs
3.3 mg per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis DE-111 monograph & interactions

BioCore Optimum Complete

110 mg per serving
  • › Amylase
  • › Protease
  • › Lactase
  • › Peptidase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Acid Maltase

Other (inactive) ingredients: Rice Maltodextrin, Hypromellose, Water, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Support by Bariatric Fusion Drug Interactions

Want to check YOUR meds against Digestive Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis DE-111 182

Individual Drug Interactions

The ingredients in Digestive Support interact with 182 drugs. Click any drug to see the details.

1 of the 8 ingredients in Digestive Support interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis DE-111

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis DE-1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis DE-111 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Support, from the product label.

Bariatric Fusion

See all Bariatric Fusion products
Name
Bariatric Fusion
Street Address
2741 Transit Rd.
City
Elma
State
NY
ZipCode
14059
Phone Number
1.866.259.0602
Web Address
Bariatricfusion.com
Pharmacist Counseling Corner

Digestive Support by Bariatric Fusion: Common Questions

Does Digestive Support by Bariatric Fusion interact with any medications?
Yes. Based on its ingredients, Digestive Support has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Support contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with lactose intolerance?
Yes. Lactase, one of the enzymes in this product, is effective for lactose intolerance. It helps your body break down the milk sugar your digestive system can't handle on its own.
Can I take this if I'm on antibiotics?
You can, but separate them. Antibiotics can kill the live Bacillus subtilis probiotic in this product, which defeats the purpose. Try to take them a few hours apart.
Will this help with antibiotic-induced diarrhea?
Possibly. Bacillus subtilis is rated possibly effective for diarrhea that comes on after antibiotic use. Just remember to take it away from your antibiotic doses so it survives in your gut.
Is this safe during pregnancy?
The safety data isn't complete for all ingredients. Lactase is likely safe, but protease safety isn't established and Bacillus subtilis hasn't enough data. Talk with your doctor or pharmacist before you start.
What does protease do?
Protease is an enzyme that breaks down proteins in the food you eat, helping your digestive system process them more easily.
Can I take this if I'm breastfeeding?
There's limited safety data for protease and Bacillus subtilis during breastfeeding, so ask your doctor or pharmacist first. Lactase acts only in your gut and is less of a concern, but it's still worth a quick check.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Support label
Go deeper

The Full Monographs Behind Digestive Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digestive Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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