Interactions on record — worth a quick check against your medications. Based on 4 of 11 ingredients. Check your meds →
Dietary supplement

DigestPlex Ingredients & Drug Interactions

by NF NutriPlex Formulas

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

DigestPlex is a dietary supplement by NF NutriPlex Formulas with 11 active ingredients. Its ingredients are commonly taken for high blood pressure, exercise and athletic performance, heart and circulation support.Based on those ingredients, 883 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet, Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of DigestPlex by NF NutriPlex Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 11 active ingredients.
  • “DigestPlex Proprietary Blend” is a proprietary blend — the label gives one combined amount (262.50 mg) without saying how much of each component you get.

DigestPlex contains 11 active ingredients designed to support digestion. The core components are digestive enzymes: protease and pepsin (which break down proteins), lipase (which breaks down fats), amylase (which breaks down carbohydrates), pancreatin (a blend of digestive enzymes from pork pancreas), and malt diastase (an enzyme that breaks down starches).

The formula also includes betaine hydrochloride (which increases stomach acid), beet (a source of nutrients and compounds), glutamic acid (an amino acid), ox bile extract (which aids fat digestion), and citrus pectin cellulose (a fiber). Inactive ingredients—microcrystalline cellulose, arrowroot, hydroxypropyl cellulose, croscarmellose sodium, and silicon dioxide—are fillers and binders that form the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive enzymes support.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating and gas, Fat digestion.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for DigestPlex's individual ingredients is limited. Beet is possibly effective for athletic performance and exercise-induced muscle soreness, but the enzymes and other components lack reliable evidence to establish whether they work for their digestive purposes.

Lipase, betaine hydrochloride, and several others have been studied for conditions like indigestion (dyspepsia) and inflammatory bowel disease, but the available data is insufficient to rate them. We don't have effectiveness data on file for amylase, protease, pepsin, pancreatin, or malt diastase as digestive aids in supplement form.

The evidence, ingredient by ingredient Beet Proteolytic Enzymes (proteases) Lipase Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and pepsin are generally well tolerated but may cause digestive upset or allergic reactions in some people; rarely, occupational airborne exposure to pepsin has triggered allergic rhinitis or asthma. Lipase is generally well tolerated in supplement form, though serious digestive conditions warrant medical guidance.

Beet is widely eaten as food and generally well tolerated, but concentrated supplements lack safety data—most common side effects are harmless red or black stools, though very large amounts theoretically could cause low blood calcium or kidney issues. Betaine hydrochloride may irritate the stomach and is unsafe for people with ulcers, gastritis, or true acid reflux, and could cause heartburn.

Regarding pregnancy: protease, pepsin, betaine hydrochloride, and lipase all lack adequate safety data and should be avoided or used only under medical advice. For breastfeeding, protease and pepsin carry little safety data; lipase and betaine hydrochloride are not well studied.

Amylase, glutamic acid, citrus pectin cellulose, ox bile extract, pancreatin, and malt diastase have no pregnancy or breastfeeding data on file.

Side effects, ingredient by ingredient Beet Proteolytic Enzymes (proteases) Lipase Betaine Hydrochloride

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Beet, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • For scale: 884 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DigestPlex, double-check with your doctor or pharmacist if you take any of these: drugs metabolized by the liver enzyme CYP3A4 (including certain statins, some blood pressure and heart medications, and immunosuppressants)—beet may increase their levels; H2-blockers, antacids, or proton pump inhibitors (PPIs)—betaine hydrochloride may reduce their effectiveness; or blood pressure medications—beet's nitrates may theoretically lower blood pressure further. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

DigestPlex is a multi-enzyme digestive supplement, though strong evidence for its effectiveness is lacking. If you take acid-reducing medications (antacids, H2-blockers, or PPIs), blood pressure drugs, or medications processed by your liver, you'll need to check with your doctor or pharmacist before starting it because beet and betaine hydrochloride may interfere.

It's not recommended in pregnancy or breastfeeding without medical advice. Talk it over with your own healthcare provider to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DigestPlex, straight from the product label.

Brand NF NutriPlex Formulas
Barcode (UPC) 670541998335
Net contents 125 Tablet(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304455
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DigestPlex by NF NutriPlex Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
125
UPC/BARCODE
670541998335
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Glutamic Acid0 NP--
Betaine Hydrochloride0 NP--
Beet100 mg--
Citrus Pectin Cellulose0 NP--
Pepsin0 NP--
Ox Bile extract65 mg--
Pancreatin75 mg--
Malt Diastase0 NP--
DigestPlex Proprietary Blend262.5 mg--

Other ingredients: Microcrystalline Cellulose, Arrowroot, Hydroxypropyl Cellulose, Croscarmellose Sodium, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Digestive Enzymes

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 tablet only with meal, or as directed by healthcare practitioner.

Precautions

Pregnant and lactating women, as well as persons under medical care or on prescription drugs should always consult with physician before consuming this or any other supplement.

Keep away from children.

Tamper resistant package.

Storage

Store in a cool, dry place.

Formulation

Contains no yeast, soy, milk/dairy, corn, artificial flavors, sterilized substances, genetically engineered ingredients, artificial coloring or preservatives.

See for yourself

DigestPlex by NF NutriPlex Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in DigestPlex by NF NutriPlex Formulas

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container125 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beet

Interacts with
861 drugs
100 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet monograph & interactions

Ox Bile extract

65 mg per serving

Pancreatin

75 mg per serving

DigestPlex Proprietary Blend

262.5 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Arrowroot, Hydroxypropyl Cellulose, Croscarmellose Sodium, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

DigestPlex by NF NutriPlex Formulas Drug Interactions

Want to check YOUR meds against DigestPlex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
883Drugs
643 Moderate 240 Minor

Ingredients driving the most interactions

Beet 861

Each ingredient & the kinds of drugs it affects

For each ingredient in DigestPlex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for DigestPlex, from the product label.

NF NutriPlex Formulas

See all NF NutriPlex Formulas products
Name
NutriPlex Formulas, Inc.
Street Address
3020 Carbon Pl #202
City
Boulder
State
CO
ZipCode
80301
Web Address
nutriplexformulas.com
Pharmacist Counseling Corner

DigestPlex by NF NutriPlex Formulas: Common Questions

Does DigestPlex by NF NutriPlex Formulas interact with any medications?
Yes. Based on its ingredients, DigestPlex has a known interaction with 883 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DigestPlex contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do the enzymes in DigestPlex actually do?
Protease breaks down proteins, lipase breaks down fats, and amylase and malt diastase break down carbohydrates and starches. Pepsin and pancreatin are also digestive enzymes, and ox bile extract helps with fat digestion. Together they're meant to support your digestive system, though good evidence for how well they work as supplements isn't on file.
Is DigestPlex safe if I'm pregnant or breastfeeding?
The safety data isn't there for most ingredients during pregnancy or breastfeeding. Betaine hydrochloride, protease, and pepsin are best avoided in pregnancy unless your doctor prescribes them. Talk with your doctor or pharmacist before taking DigestPlex while pregnant or nursing to see what fits your situation.
Can DigestPlex cause side effects?
Most people tolerate it well, but digestive upset or allergic reactions are possible, especially with the enzyme ingredients. Beet may cause harmless red or black stools. Betaine hydrochloride could cause heartburn or stomach irritation, particularly if you have ulcers or acid reflux. If you notice any unusual symptoms, stop and talk to your pharmacist.
Will DigestPlex interfere with my acid reflux medication?
If you take an antacid, H2-blocker, or proton pump inhibitor (PPI) for reflux or heartburn, betaine hydrochloride in this product may work against those drugs by raising stomach acid. Check with your doctor or pharmacist before combining them—it may not be the right choice for you.
What's beet doing in a digestive supplement?
Beet provides nutrients and compounds that research suggests may help with athletic performance and exercise-related muscle soreness. It's also a whole-food ingredient, though the concentrated form in supplements hasn't been studied as thoroughly as eating beet as food.
Can I take DigestPlex with my cholesterol or blood pressure medication?
It depends on which medication you take. Beet may increase levels of drugs processed by your liver, including some statins and blood pressure medications, which could make them stronger. Run the exact name of your medication through the interaction checker on this page, and if you're uncertain, ask your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DigestPlex is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DigestPlex label
Sources

Sources & How We Checked

DigestPlex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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