Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

AdrenaPlex Ingredients & Drug Interactions

by NF NutriPlex Formulas

AdrenaPlex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AdrenaPlex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

AdrenaPlex is a dietary supplement by NF NutriPlex Formulas with 3 active ingredients. Its ingredients are commonly taken for vitamin c source, immune support, antioxidant support.Based on those ingredients, 128 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acerola Cherry Juice, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against AdrenaPlex by NF NutriPlex Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with AdrenaPlex by NF NutriPlex Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of AdrenaPlex by NF NutriPlex Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

AdrenaPlex contains 3 active ingredients. Bovine adrenal (lyophilized powder) is included to support adrenal function, though we hold no interaction data on file for it.

Acerola cherry juice powder supplies vitamin C — a well-known antioxidant — and sunflower rounds out the blend. The product also contains inactive ingredients (gelatin capsule, water, microcrystalline cellulose, and silica) as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Acerola's overall clinical evidence instead.

Moderate

Some clinical evidence supports Acerola for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Vitamin C deficiency — rated "Possibly Effective" (Natural Medicines).

Acerola cherry powder is possibly effective for vitamin C deficiency. For other proposed uses — atherosclerosis, common cold, and diarrhea — the evidence isn't established in the data we hold.

We have no effectiveness ratings on file for bovine adrenal or sunflower as ingredients in this product.

The evidence, ingredient by ingredient Acerola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acerola is generally considered safe when used in food amounts or as directed on the label. That said, concentrated supplements haven't been well studied for safety.

Large doses of vitamin C (over 2,000 mg daily) can cause osmotic diarrhea and GI upset. There's one case report of a person with a history of latex sensitivity developing a rash, shortness of breath, and rapid heartbeat after consuming acerola juice — cross-reactivity with latex was confirmed in that patient.

Another case describes rectal obstruction in a child who ate acerola fruits daily for a week. For pregnancy and lactation, the facts on file don't include safety information — talk with your doctor or pharmacist about whether this product is right for you during those periods.

Side effects, ingredient by ingredient Acerola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Acerola.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments.
  • For scale: 128 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you're on chemotherapy drugs (alkylating agents or antitumor antibiotics — Moderate risk), estrogens or birth control, aspirin, warfarin (a blood thinner), or aluminum-containing antacids. All are documented as Minor to Moderate interactions with acerola.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product might work for you if you're looking to support your adrenal health or boost vitamin C intake. If you take chemotherapy, hormonal birth control, blood thinners, or aspirin, check your medications with the tool below first.

Pregnant or nursing? Chat with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AdrenaPlex, straight from the product label.

Brand NF NutriPlex Formulas
Barcode (UPC) 670541998281
Net contents 125 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304451
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AdrenaPlex by NF NutriPlex Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
63
UPC/BARCODE
670541998281
IngredientAmount% DV
Proprietary Blend400 mg--
Bovine Adrenal, Lyophilized, Powder160 mg--
Acerola Cherry Juice, Powder0 NP--
Sunflower0 NP--

Other ingredients: Gelatin, Water, Microcrystalline Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A 100% Whole Food Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 2 capsules twice daily or as directed by healthcare practitioner.

Precautions

Pregnant and lactating women, as well as persons under medical care or on prescription drugs should always consult with physician before consuming this or any other supplement.

Keep away from children.

Tamper resistant package.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AdrenaPlex by NF NutriPlex Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AdrenaPlex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AdrenaPlex by NF NutriPlex Formulas

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container63 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

400 mg per serving

Bovine Adrenal, Lyophilized, Powder

160 mg per serving

Other (inactive) ingredients: Gelatin, Water, Microcrystalline Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

AdrenaPlex by NF NutriPlex Formulas Drug Interactions

Want to check YOUR meds against AdrenaPlex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
128Drugs
39 Moderate 89 Minor

Ingredients driving the most interactions

Acerola Cherry Juice, Powder 128

Individual Drug Interactions

The ingredients in AdrenaPlex interact with 128 drugs. Click any drug to see the details.

1 of the 3 ingredients in AdrenaPlex interact with drugs. Each result below shows which ingredient is responsible. Acerola Cherry Juice, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in AdrenaPlex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Acerola Cherry Juice, Powder6 drug types · 128 drugs

Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.
Acerola contains vitamin C, an antioxidant. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as alkylating agents. In contrast, other researchers theorize that antioxidants might make alkylating chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.
Acerola contains vitamin C, an antioxidant. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as antitumor antibiotics. In contrast, other researchers theorize that antioxidants might make antitumor antibiotic chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on antitumor antibiotic chemotherapy.

Likelihood Possible Evidence D
Aluminum

Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.
Acerola contains vitamin C. It is thought that vitamin C chelates aluminum, keeping it in solution and available for absorption. In people with normal renal function, urinary excretion of aluminum likely increases, making aluminum retention and toxicity unlikely. However, patients with renal failure who take aluminum-containing compounds, such as phosphate binders, should avoid acerola in doses that provide more vitamin C than the recommended dietary allowances.

Likelihood Possible Evidence D
Aspirin

Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.
Acerola contains vitamin C. It has been suggested that acidification of the urine by vitamin C can decrease the urinary excretion of salicylates, increasing plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion. The vitamin C content of acerola is typically about 2000 mg per 100 grams. Thus, a clinically significant interaction between acerola and aspirin is unlikely.

Likelihood Unlikely Evidence B
Estrogens

Theoretically, concomitant use of acerola with estrogens might increase estrogenic effects.
Acerola contains vitamin C. Increases in plasma estrogen levels of up to 55% have occurred under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. However, increases in plasma estrogen levels may occur when women who are deficient in vitamin C take supplements.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, acerola might reduce the effectiveness of warfarin; however, its vitamin C content is likely too low to produce clinically significant effects.
Acerola contains vitamin C. High doses of vitamin C may reduce the response to warfarin, possibly by causing diarrhea and reducing warfarin absorption. This occurred in two people who took up to 16 grams daily of vitamin C, and resulted in decreased prothrombin time. Lower doses of 5-10 grams daily of vitamin C can also reduce warfarin absorption, but this does not seem to be clinically significant. The vitamin C content of acerola is typically about 2000 mg per 100 grams. Thus, a clinically significant interaction between acerola and warfarin is unlikely.

Likelihood Unlikely Evidence D
Acerola Cherry Juice, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AdrenaPlex, from the product label.

NF NutriPlex Formulas

See all NF NutriPlex Formulas products
Name
NutriPlex Formulas, Inc.
Street Address
150 Murray St. #1145
City
Niwot
State
CO
ZipCode
80544
Web Address
nutriplexformulas.com
Pharmacist Counseling Corner

AdrenaPlex by NF NutriPlex Formulas: Common Questions

Does AdrenaPlex by NF NutriPlex Formulas interact with any medications?
Yes. Based on its ingredients, AdrenaPlex has a known interaction with 128 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AdrenaPlex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my birth control?
Acerola contains vitamin C, which theoretically might increase blood levels of estrogen from hormonal contraceptives. It's a Minor interaction, but worth mentioning to your doctor or pharmacist — they may want to keep an eye on breakthrough bleeding or other signs.
Can I take this if I'm on chemotherapy?
Acerola's antioxidant vitamin C might reduce how well some chemo drugs (alkylating agents and antitumor antibiotics) work. This is a Moderate concern — don't add this without talking to your oncologist first.
Is acerola safe for kids?
Food amounts are fine, but there's one case report of a child who developed a bowel blockage after eating acerola fruits daily for a week. Stick to the label dose and watch for any GI upset, and ask your pediatrician if you're unsure.
What does bovine adrenal do?
Bovine adrenal powder is included to support your body's adrenal function, but we don't hold data on how well it works or how it might interact with medications.
Could this cause an allergic reaction?
Most people tolerate acerola well, but there's one report of someone with a latex allergy developing a rash, shortness of breath, and rapid heartbeat after acerola juice — cross-reactivity with latex was found. If you have a latex allergy, mention this product to your doctor before using it.
Will this upset my stomach?
At label doses, acerola is generally well tolerated. Very high doses of vitamin C (over 2,000 mg daily) can cause diarrhea and GI upset, but this product is unlikely to reach that level. If you have a sensitive stomach, start small and see how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AdrenaPlex label
Go deeper

The Full Monographs Behind AdrenaPlex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acerola

Interacts with 128 drugs

Acerola is a small tropical fruit prized for its very high natural vitamin C content, and it is mostly used as a food-based source of vitamin C and antioxidants. While vitamin C itself has w...

Read the full Acerola monograph →
Sources

Sources & How We Checked

AdrenaPlex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acerola 20 references
  1. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  2. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  3. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  6. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  7. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  8. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  9. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  10. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  11. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  12. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  13. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  14. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  15. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
  16. Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
  17. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  18. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  19. Denadai R, Souza FM, Valle MR. Fecal impaction by rectal acerola bezoar. Indian J Pediatr 2013;80(5):432-3. PubMed
  20. Raulf-Heimsoth M, Stark R, Sander I, et al. Anaphylactic reaction to apple juice containing acerola: cross-reactivity to latex due to prohevein. J Allergy Clin Immunol 2002;109(4):715-6. PubMed

See these in context on the Acerola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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