Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

DIM + I3C with PQQ Ingredients & Drug Interactions

by Seeking Health

DIM + I3C with PQQ label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM + I3C with PQQ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM + I3C with PQQ is a dietary supplement by Seeking Health with 3 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 365 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indole-3-Carbinol, Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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HelloPharmacist Scorecard of DIM + I3C with PQQ by Seeking Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients. Diindolylmethane and indole-3-carbinol are both compounds found in cruciferous vegetables like broccoli and cabbage.

LifePQQ is a proprietary form of pyrroloquinoline quinone, a compound that appears in some foods and fermented products. The inactive ingredients are hydroxypropyl methylcellulose, water, and L-leucine.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Estrogen metabolism and hormone balance support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Breast cancer, Cervical dysplasia, Mastalgia, Premenstrual syndrome (PMS), Prostate cancer — and 3 related terms.
  • The closest evidence on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Breast cancer (Natural Medicines).
  • Also on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Cervical dysplasia.
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Breast cancer, Cervical dysplasia, Mastalgia, and more.

The evidence for what these ingredients actually accomplish isn't well established in the data we hold. For diindolylmethane, there's insufficient reliable evidence to rate its use for benign prostatic hyperplasia, breast cancer, colorectal cancer, cervical dysplasia, or breast pain.

The same goes for indole-3-carbinol across breast cancer, colorectal cancer, cervical dysplasia, liver disease, and fibromyalgia. We have no effectiveness data for LifePQQ.

The evidence, ingredient by ingredient Diindolylmethane Indole-3-carbinol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both diindolylmethane and indole-3-carbinol are generally well tolerated, though the long-term safety of diindolylmethane hasn't been nailed down. Common side effects of diindolylmethane include diarrhea, gas, headache, nausea, rash, and vomiting.

Indole-3-carbinol may cause diarrhea, imbalance, nausea, rash, tremor, and unsteadiness — imbalance and tremor showed up at higher doses in a couple of cases and resolved when doses dropped. A rare but serious effect reported with diindolylmethane is DRESS (a skin and systemic reaction).

Because both ingredients have possible effects on hormones, the safety data advises against use while breastfeeding. Diindolylmethane is rated Likely Safe in pregnancy, but indole-3-carbinol has insufficient data.

Side effects, ingredient by ingredient Diindolylmethane Indole-3-carbinol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Indole-3-carbinol, Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 365 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check whether you're on estrogen-containing drugs (including hormonal birth control and hormone replacement therapy) — both ingredients might raise or lower their effects. If you take blood thinners or antiplatelet drugs like warfarin or clopidogrel, indole-3-carbinol may increase bleeding risk.

Sodium-depleting diuretics paired with diindolylmethane carry a Moderate risk of low sodium. A few other medications metabolized by your liver may become less effective, though this hasn't been confirmed in people yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take estrogen medications, blood thinners, diuretics, or certain other prescription drugs, check your exact medications on this page before starting. The long-term safety of these ingredients isn't well known, and the evidence for what they actually do is still developing.

Your pharmacist can help you weigh whether this makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM + I3C with PQQ, straight from the product label.

Brand Seeking Health
Barcode (UPC) 810007520278
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 322643
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM + I3C with PQQ by Seeking Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
810007520278
IngredientAmount% DV
Diindolylmethane200 mg--
Indole-3-Carbinol200 mg--
LifePQQ4 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule, 1 to 2 times daily, or use as directed by your healthcare professional.

Precautions

Children and pregnant or lactating women should consult their healthcare professional prior to use.

Children and pregnant or lactating women should consult their healthcare professional prior to use.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formula

This product contains a mixture of two important dietary indoles, indole-3-carbinol (I3C) and diindolymethane (DIM). Since I3C undergoes biochemical transformation to related indole metabolites, broad-spectrum indoles may be present upon ingestion. DIM + I3C supports healthy estrogen metabolism.

Formulation

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, gluten, GMO, artificial colors, or artificial flavors.

DIM + I3C meets or exceeds cGMP Quality Standards. Manufactured in the USA from globally sourced ingredients Third-party independently tested

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Seeking Health Targeted Support

LifePQQ is a trademark of Nutraland USA, Inc. Life PQQ

FDA Statement of Identity

Dietary Supplement

General Statements

Find other effective health products at www.seekinghealth.com This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM + I3C with PQQ by Seeking Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM + I3C with PQQ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM + I3C with PQQ by Seeking Health

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
200 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Indole-3-Carbinol

Interacts with
294 drugs
200 mg per serving

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...

Indole-3-Carbinol monograph & interactions

LifePQQ

4 mg per serving Form: Pyrroloquinoline Quinone Disodium Salt

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM + I3C with PQQ by Seeking Health Drug Interactions

Want to check YOUR meds against DIM + I3C with PQQ?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
365Drugs
365 Moderate

Ingredients driving the most interactions

Indole-3-Carbinol 294
Diindolylmethane 269

Individual Drug Interactions

The ingredients in DIM + I3C with PQQ interact with 365 drugs. Click any drug to see the details.

2 of the 3 ingredients in DIM + I3C with PQQ interact with drugs. Each result below shows which ingredient is responsible. Indole-3-Carbinol Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM + I3C with PQQ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM + I3C with PQQ, from the product label.

Seeking Health

See all Seeking Health products
Name
Seeking Health, LLC
Street Address
3140 Mercer Ave
City
Bellingham
State
WA
ZipCode
98225
Phone Number
(800) 547-9812
Web Address
www.seekinghealth.com
Pharmacist Counseling Corner

DIM + I3C with PQQ by Seeking Health: Common Questions

Does DIM + I3C with PQQ by Seeking Health interact with any medications?
Yes. Based on its ingredients, DIM + I3C with PQQ has a known interaction with 365 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM + I3C with PQQ contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
Diindolylmethane is rated Likely Safe in pregnancy based on the data we hold. Indole-3-carbinol doesn't have enough safety information available. Talk with your doctor or pharmacist for personalized advice based on your individual situation.
What side effects should I watch for?
The most common are digestive — diarrhea, gas, and nausea — plus headache, rash, and vomiting. At higher doses, indole-3-carbinol has caused imbalance and tremor that improved when the dose was reduced. A rare but serious rash reaction (DRESS) has been reported with diindolylmethane.
Does this actually work for anything?
We don't have enough reliable evidence in our data to say whether these ingredients work for the conditions they're marketed for — breast cancer, prostate health, colorectal cancer, and others. The research so far is insufficient to rate them.
What's LifePQQ and does it interact with anything?
LifePQQ is a proprietary form of pyrroloquinoline quinone. We don't hold interaction data for it, so we can't tell you whether it has drug interactions. Your pharmacist might be able to help you track that down separately.
Is this safe for long-term use?
Diindolylmethane is generally well tolerated, but long-term safety hasn't been established. Indole-3-carbinol is likely fine in food amounts, but supplement doses are less studied. Talk to your pharmacist if you're thinking about taking this long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DIM + I3C with PQQ is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM + I3C with PQQ label
Go deeper

The Full Monographs Behind DIM + I3C with PQQ’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph →
Sources

Sources & How We Checked

DIM + I3C with PQQ's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Indole-3-carbinol 9 references
  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
  3. He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
  4. Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
  5. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  6. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
  7. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
  8. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  9. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

See these in context on the Indole-3-carbinol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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