Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Double Strength Graviola 1000 mg Ingredients & Drug Interactions

by NOW

Double Strength Graviola 1000 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Double Strength Graviola 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Double Strength Graviola 1000 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Soursop. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Double Strength Graviola 1000 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Double Strength Graviola 1000 mg by NOW — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Double Strength Graviola 1000 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: soursop (from graviola), supplied at 1,000 mg per tablet. The inactive ingredients are hydroxypropyl cellulose, croscarmellose sodium, stearic acid, vegetarian coating, and silicon dioxide — standard tablet binders and flow agents.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Healthy cell function and free radical scavenging.
  • We looked for evidence on: Antioxidant support, Cellular health, Oxidative stress.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for soursop's effectiveness isn't established in the data we hold. The product is marketed for human papillomavirus (HPV), headache, male infertility, and as an insect repellent, but we have insufficient reliable evidence to rate any of those uses.

That doesn't mean it doesn't work — it means large, well-designed human studies haven't yet settled the question.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular use of graviola raises caution flags. The most common side effects in trials were nausea and burning pain in the upper abdomen.

Rare but serious concerns include movement disorders and myeloneuropathy (a type of nerve damage), with symptoms that can resemble Parkinson disease. One observational study found that even low amounts of graviola in people with Parkinson disease were linked to worsening of motor and cognitive symptoms.

Long-term safety data in humans are limited, and lab work suggests possible nerve toxicity with prolonged use. Graviola is rated possibly unsafe in pregnancy and unsafe while breastfeeding — the safety data simply aren't there, so it's best avoided during both.

If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before taking this product.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol), check with your pharmacist before taking this product — graviola may lower the drug's blood levels and reduce how well it controls seizures. No other medications are documented to interact with the soursop in this product in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take carbamazepine (Tegretol) for seizures, do not take this product without talking to your doctor first — it may reduce your seizure medication's effectiveness. Graviola's safety profile in humans is limited and raises concerns about nerve damage with regular use.

If you're pregnant or breastfeeding, avoid it. For anyone else, check your medications on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Double Strength Graviola 1000 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739046932
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206120
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Double Strength Graviola 1000 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
733739046932
IngredientAmount% DV
Soursop1 Gram(s)--

Other ingredients: Hydroxypropyl Cellulose, Croscarmellose Sodium, Stearic Acid, Vegetarian Coating, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 tablet daily.

Formula

Graviola tree (Annona muricata), also known as soursop, is found in tropical areas of the world. Its leaves have a long history of use by traditional herbalists. More recent scientific studies suggest that acetogenins, the active constituents of Graviola, can support healthy cell growth and function. Other active compounds found in Graviola leaves have free radical scavenging properties.

Triangle K

This double strength product has twice the graviola (1,000 mg per tablet) than our regular strength product (500 mg per capsule).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Do not take this product if you have any neurodegenerative disorders or Parkinson’s disease, or are taking any antihypertensive or MAO inhibitor medications. Not recommended for pregnant/nursing women. Consult physician if taking medication or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

General Statements

Healthy cell function Free radical scavenger

Botanicals/Herbs Family owned since 1968.

Natural color variation may occur in this product.

Seals/Symbols

Non-GMO Triangle K

GMP Quality Assured

Formulation

Non-GMO

Vegetarian/Vegan

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Double Strength Graviola 1000 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Double Strength Graviola 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Double Strength Graviola 1000 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Soursop

Interacts with
1 drug
1 Gram(s) per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Soursop monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Cellulose, Croscarmellose Sodium, Stearic Acid, Vegetarian Coating, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Double Strength Graviola 1000 mg by NOW Drug Interactions

Want to check YOUR meds against Double Strength Graviola 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Soursop 1

Individual Drug Interactions

The ingredients in Double Strength Graviola 1000 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Double Strength Graviola 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Soursop

Each ingredient & the kinds of drugs it affects

For each ingredient in Double Strength Graviola 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Soursop1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Soursop full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Double Strength Graviola 1000 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Double Strength Graviola 1000 mg by NOW: Common Questions

Does Double Strength Graviola 1000 mg by NOW interact with any medications?
Yes. Based on its ingredients, Double Strength Graviola 1000 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Double Strength Graviola 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No — graviola is rated possibly unsafe in pregnancy and unsafe while breastfeeding because safety data don't exist. If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before using this product.
What are the most common side effects?
Nausea and burning pain in the upper abdomen are the most common side effects reported in trials. Rare but serious effects — movement disorders and nerve damage — have also been reported with regular use.
Does graviola actually work for HPV or headaches?
We don't have enough reliable human evidence to say. The product is marketed for HPV, headaches, male infertility, and as an insect repellent, but the evidence to rate any of those uses isn't established in our data.
Is this product safe for long-term daily use?
The data here suggest caution. Regular consumption may be unsafe, and lab studies raise concerns about possible nerve toxicity with long-term use. Talk with your pharmacist about how long you plan to take it.
What's in this besides soursop?
The tablet contains inactive binders and flow agents — hydroxypropyl cellulose, croscarmellose sodium, stearic acid, vegetarian coating, and silicon dioxide. There are no other active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Double Strength Graviola 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Double Strength Graviola 1000 mg label
Go deeper

The Full Monographs Behind Double Strength Graviola 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Double Strength Graviola 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team