Graviola Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Graviola (Annona muricata) dried leaf liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: certified organic Graviola (Annona muricata) dried leaf liquid extract. The liquid also contains menstruum, a solvent used to extract and preserve the herb.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that graviola is effective for any of the conditions it's marketed for—including human papillomavirus (HPV), headache, male infertility, or as an insect repellent. All the effectiveness ratings in our data show insufficient reliable evidence to make a clear claim.
How safe is it?
Well-documented data
Regular use of graviola raises several safety concerns. The most common side effects from oral use are stomach pain and nausea; in one clinical trial, some people reported nausea and burning stomach pain at a dose of 300 mg daily.
Rare but serious side effects include movement disorders and nerve damage (myeloneuropathy) that can resemble Parkinson disease. Lab studies also raise concerns about possible nerve toxicity with long-term use.
Additionally, a large observational study found that even low cumulative intake of graviola—whether fruit, juice, or herbal tea—was tied to worsened movement and thinking symptoms in people with Parkinson disease. Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol), a seizure medication, check with your doctor or pharmacist before using this product. Graviola may lower carbamazepine levels and reduce how well it controls seizures.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
We don't have reliable evidence that graviola works for any stated purpose, and the safety concerns—especially rare but serious nerve effects and movement problems—are significant. If you're taking carbamazepine (Tegretol) for seizures, this product could interfere with your medication.
Talk with your doctor or pharmacist before starting it, especially if you're pregnant, breastfeeding, or have a family history of Parkinson disease.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7429523299242 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2020 |
| DSLD ID | 235064 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| certified organic Graviola (Annona muricata) dried leaf liquid extract | 970 mg | -- |
Other ingredients: Menstruum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Origin of plant material: Brazil.
Manufactured in the USA in an FDA registered facility
Alcohol free
Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract
Non GMO
No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free
Suggested/Recommended/Usage/Directions
Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.
FDA Disclaimer Statement
Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Caution May have contraindications.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing, or if you are on any medications.
Keep out of the reach of children.
Storage
Store in a cool, dry, dark place.
Formula
Annona muricata
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Made in an FDA registered facility Natural Gluten Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Certified organic Graviola (Annona muricata) dried leaf liquid extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Certified organic Graviola (Annona muricata) dried leaf liquid extract monograph & interactionsOther (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.
Graviola by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Herbal Terra's Graviola interacts with carbamazepine (Tegretol), a seizure medication.
The interaction is Moderate in severity: graviola may lower the amount of carbamazepine in your blood, potentially making the drug less effective at controlling seizures. In a rat study, graviola extract reduced carbamazepine levels by about 46%.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, do not start this product without talking to your doctor or pharmacist first. They'll need to check whether you need a dose adjustment or a different medication altogether.
Use the interaction checker on this page to search your complete medication list, but carbamazepine is the one documented interaction we have for graviola.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola interact with drugs. Each result below shows which ingredient is responsible. certified organic Graviola (Annona muricata) dried leaf liquid extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Graviola (annona Muricata) Dried Leaf Liquid ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Certified Organic Graviola (annona Muricata) Dried Leaf Liquid Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
certified organic Graviola (Annona muricata) dried leaf liquid extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola, from the product label.
Graviola by Herbal Terra: Common Questions
Does Graviola by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What side effects does graviola have?
Can I take graviola if I'm pregnant?
Is it safe while breastfeeding?
Does graviola actually work for HPV or headaches?
Why is there a concern about Parkinson disease?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC