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Dietary supplement

Graviola 500 mg Ingredients & Drug Interactions

by LuckyHerbs

Graviola 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola 500 mg is a dietary supplement by LuckyHerbs with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Soursop. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola 500 mg by LuckyHerbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 500 mg by LuckyHerbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Graviola 500 mg by LuckyHerbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: soursop (also called graviola), supplied as 500 mg per capsule. The capsules themselves include inactive ingredients like hypromellose, magnesium stearate, and silicon dioxide—standard capsule materials and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Graviola product and its label doesn't state a use — see Graviola's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for graviola's effectiveness isn't established. For the uses studied—human papillomavirus (HPV), headache, and insect repellent, plus male infertility—the data we hold shows insufficient reliable evidence to rate how well it works.

In short, we don't have solid research backing these claims yet.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular graviola use carries safety cautions. Some people report nausea and upper stomach pain (epigastrium pain), especially at higher doses.

More concerning, long-term graviola consumption is linked in rare cases to movement disorders and nerve damage (myeloneuropathy) that can resemble Parkinson disease—and a large study suggests that even small amounts of graviola may worsen symptoms in people who already have Parkinson disease. Lab studies also raise questions about possible nerve toxicity with long-term use.

Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to lack of safety data. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures, graviola may lower your blood levels of this medication and reduce how well it works. Talk with your doctor or pharmacist before combining them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola's traditional uses—for HPV, headache, and insect control—aren't backed by strong evidence in the data we hold. The bigger concern is safety: regular use may cause nausea, stomach pain, and in rare cases serious nerve problems that resemble Parkinson disease.

It's not recommended in pregnancy or while breastfeeding. If you take carbamazepine or have Parkinson disease, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola 500 mg, straight from the product label.

Brand LuckyHerbs
Barcode (UPC) 810026421679
Net contents 100 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283191
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola 500 mg by LuckyHerbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
50
UPC/BARCODE
810026421679
IngredientAmount% DV
Soursop1 Gram(s)--

Other ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 2 capsules 3 to 4 times daily as needed.

Formula

Graviola tree (Annona muricata), also known as soursop, is found in tropical areas of the world. Its leaves have a long history of use by traditional herbalists. More recent scientific studies suggest that ace-togenins, the active constituents of graviola, can support healthy cell growth and function. Other active compounds found in graviola leaves have free radical scavenging properties.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Do not take this product if you have any neurodegenerative disorders or Parkinson's disease, or are taking any antihypertensive or MAO inhibitor medications. Not recommended for pregnant/nursing women. Consult physician if taking medication or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Vegan

Healthy Cell Function Free radical scavenger

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

General Statements

1 year happiness guarantee

Seals/Symbols

Guaranteed Quality & Potency

Brand IP Statement(s)

Lucky Herbs Herbal Supplements by Lucky Vitamin

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola 500 mg by LuckyHerbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola 500 mg by LuckyHerbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Soursop

Interacts with
1 drug
1 Gram(s) per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Soursop monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola 500 mg by LuckyHerbs Drug Interactions

Want to check YOUR meds against Graviola 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Soursop 1

Individual Drug Interactions

The ingredients in Graviola 500 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola 500 mg interact with drugs. Each result below shows which ingredient is responsible. Soursop

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Soursop1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Soursop full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola 500 mg, from the product label.

LuckyHerbs

See all LuckyHerbs products
Name
Lucky Health Group Inc.
City
Conshohocken
State
PA
ZipCode
19428
Phone Number
1-888-635-0474
Web Address
www.LuckyVitamin.com
Pharmacist Counseling Corner

Graviola 500 mg by LuckyHerbs: Common Questions

Does Graviola 500 mg by LuckyHerbs interact with any medications?
Yes. Based on its ingredients, Graviola 500 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. Graviola is rated possibly unsafe in pregnancy, and there's not enough safety data to use it while breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.
What are the common side effects?
The most common are nausea and upper stomach pain (epigastrium pain), especially with regular use. In rare cases, people have reported movement disorders and nerve damage that can resemble Parkinson disease.
Is graviola proven to work for HPV, headaches, or male infertility?
No—the evidence isn't established. For those uses, we have insufficient reliable data to say whether it works.
Should I avoid this if I have Parkinson disease?
Yes. A large study found that even low amounts of graviola are linked to worsening of motor and thinking symptoms in people with Parkinson disease. You should avoid it and talk with your doctor if you're at risk.
What is soursop?
Soursop, also called graviola, is a tropical fruit. It's been used in traditional medicine, but the human safety data are limited and lab studies raise concerns about possible nerve toxicity with long-term use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola 500 mg label
Go deeper

The Full Monographs Behind Graviola 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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