Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Drink Mix Ingredients & Drug Interactions

by Nature's Sunshine

Drink Mix label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Drink Mix against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Drink Mix is a dietary supplement by Nature's Sunshine with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,097 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Aloe Vera, Sodium Copper Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Drink Mix by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Drink Mix by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Drink Mix by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (5.30 Gram(s)) without saying how much of each component you get.

This drink mix contains 5 active ingredients. Sodium copper chlorophyllin (a semi-synthetic form of chlorophyll) is included for oral health and detoxification support.

Potassium is an electrolyte that helps maintain heart rhythm and muscle function. Aloe vera is added for digestive and skin health.

The product also contains a proprietary blend whose exact components aren't detailed on the label, plus bentonite, a type of clay often used to bind ingredients. Inactive ingredients include natural apple cinnamon flavor, malic acid, silicon dioxide, and stevia leaf extract for taste and stability.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Cleansing and digestive support.
  • We looked for evidence on: Body odor, Constipation, Fecal odor, Flatulence, Urinary odor, Wound healing — and 3 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.
  • Also on file: Chlorophyllin is rated "Possibly Ineffective" for Urinary odor.

The evidence for effectiveness is mixed across uses. Aloe vera in this product is possibly effective for acne, burns, constipation, diabetes, obesity, and psoriasis.

Chlorophyllin, however, is rated possibly ineffective for urinary odor, and the evidence is insufficient to rate it for acne, cancer, constipation, flatulence, or low white blood cell counts (leukopenia). No effectiveness data is available for potassium or the other ingredients in their specific roles in this formula.

The evidence, ingredient by ingredient Black Psyllium Potassium Chlorophyllin Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorophyllin is generally well tolerated short-term, but long-term safety data are limited. Oral chlorophyllin can theoretically cause photosensitization (increased sun sensitivity) or a rare blistering condition called pseudoporphyria.

Potassium from food is safe, but supplements can cause dangerously high blood levels, especially in people with kidney disease. Aloe latex—the part used here—causes common side effects like abdominal pain, cramps, and diarrhea; long-term overuse can deplete potassium and cause serious heart rhythm problems.

We do not have pregnancy or breastfeeding safety data on file for chlorophyllin, bentonite, potassium, or the proprietary blend. Aloe should be avoided during pregnancy (it may trigger uterine contractions and acts as a strong laxative) and while breastfeeding due to limited safety data.

Side effects, ingredient by ingredient Black Psyllium Potassium Chlorophyllin Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Black Psyllium, Aloe, Chlorophyllin, Potassium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,098 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use digoxin or other heart medications—aloe carries a major interaction risk. Also check blood thinners (warfarin, aspirin, apixaban, others), blood pressure drugs (ACE inhibitors like lisinopril or ARBs like losartan), diabetes medications, diuretics, or stimulant laxatives.

If you take any of these, talk with your pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This drink mix is not appropriate for anyone taking digoxin, blood thinners, diabetes medications, or certain blood pressure drugs without talking to their pharmacist first. If you have kidney disease, heart disease, or take diuretics, check with your doctor before using it.

Talk to your pharmacist or doctor about your medications before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Drink Mix, straight from the product label.

Brand Nature's Sunshine
Net contents 28 Drink Mix Packets
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255545
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Drink Mix by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.8 Gram(s)
Maximum serving Sizes:
6.8 Gram(s)
Servings per container
28
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates6 Gram(s)2%
Dietary Fiber4 Gram(s)14%
Sodium Copper Chlorophyllin0 NP--
Potassium160 mg3%
Proprietary Blend5.3 Gram(s)--
Bentonite0 NP--
Aloe Vera0 NP--
Psyllium0 NP--

Other ingredients: natural Apple Cinnamon flavor, Malic Acid, Silicon Dioxide, Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: Take contents of one cleansing drink mix packet 15-30 minutes before breakfast and 15-30 minutes before dinner. Mix cleansing drink mix packet in 8 ounces of juice or water. Shake, blend or stir vigorously. Drink immediately. It is recommended that an additional glass of water be consumed immediately after drink.

Maximize the benefits Eat a healthy and balanced diet Increase your physical activity Drink plenty of water throughout the day

Precautions

Do not exceed recommended dose. Not for long-term use.

Warning: Take with at least 250 ml (8 fl oz) of liquid. Do not take this product if you have difficulty swallowing.

May cause allergic reaction in persons sensitive to inhaled or ingested psyllium.

This carton was sealed for your protection. Do not use if seal is missing or damaged.

Formulation

Nature's Sunshine uses natural source materials that are subject to color variation.

Environmental pollutants can build up in the body, interfering with our natural cleansing and detoxifying processes. Nature's Sunshine CleanStart is our most popular cleanse to help support intestinal irregularity and the detoxifying processes of the body.

Dietary cleansing & detoxifying program Natural body cleanse that helps rid the body of waste and toxins

Guaranteed pure

Cleansing & detoxifying Use CleanStart or CleanStart Milk to help 'jump start' your cleansing and detoxifying program. After using CleanStart, try Detox Basics daily detoxifying program for ongoing detoxification support. Supports the natural cleansing of waste from the body Moves intestinal contents through the digestive system Naturally promotes a feeling of energy

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please recycle this carton. We are committed to you and our planet. Scan QR code to learn more.

Balanced nutrition and regular exercise will maximize the benefits achieved from use of this product. Contents 28 cleansing powdered drink mix packets

Herbal experts since 1972 New look! Same great product

56 packets 14-Day Program

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Drink Mix by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Drink Mix label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Drink Mix by Nature's Sunshine

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.8 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
4 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Potassium

Interacts with
62 drugs
160 mg per serving Form: Potassium Citrate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Proprietary Blend

5.3 Gram(s) per serving

Other (inactive) ingredients: Natural Apple Cinnamon flavor, Malic Acid, Silicon Dioxide, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Drink Mix by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Drink Mix?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,097Drugs
1 Major 574 Moderate 1,522 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Aloe Vera 461
Sodium Copper Chlorophyllin 335
Potassium 62

Individual Drug Interactions

The ingredients in Drink Mix interact with 2,097 drugs. Click any drug to see the details.

4 of the 6 ingredients in Drink Mix interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Aloe Vera Sodium Copper Chlorophyllin Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Drink Mix with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Aloe Vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Vera full monograph & interactions

Sodium Copper Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyllin full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Drink Mix, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Drink Mix by Nature's Sunshine: Common Questions

Does Drink Mix by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Drink Mix has a known interaction with 2,097 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Drink Mix contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use during pregnancy or while breastfeeding?
No. Aloe vera in this product should be avoided during pregnancy because the latex may trigger uterine contractions and act as a strong laxative. Avoid it while breastfeeding too, because safety data are limited. There isn't enough information on file about the other ingredients during pregnancy or breastfeeding, so talk with your doctor or pharmacist for personalized advice.
What does chlorophyllin do?
Chlorophyllin is a semi-synthetic form of chlorophyll, included for oral health and detoxification. The evidence shows it's possibly ineffective for urinary odor, and we don't have enough reliable data to say whether it helps with acne, cancer, or digestive issues.
Can this drink mix cause side effects?
Yes. Common side effects from aloe include abdominal pain, cramps, and diarrhea. Long-term use of aloe latex can cause serious potassium loss, leading to muscle weakness and heart rhythm problems. Chlorophyllin may cause sun sensitivity and, in rare cases, blistering. Potassium can cause nausea, vomiting, or abdominal discomfort.
I have kidney disease. Is this product safe for me?
No, not without checking with your doctor first. Potassium supplements can raise blood levels to dangerous levels in people with kidney disease, which can cause heart rhythm problems and other serious effects. Talk to your doctor or pharmacist before using this.
Will this help with constipation?
Aloe vera is possibly effective for constipation because it acts as a stimulant laxative. However, overuse can cause serious side effects including potassium loss. If you need a laxative, talk to your pharmacist about safer options and appropriate dosing.
What's the proprietary blend, and why isn't it listed?
The label lists it as a proprietary blend, which means the manufacturer keeps the exact components and amounts secret. We can't check those unlisted ingredients against medications, so bring the full product label to your pharmacist if you want them to review it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Drink Mix is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Drink Mix label
Go deeper

The Full Monographs Behind Drink Mix’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

Drink Mix's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Chlorophyllin 6 references
  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

See these in context on the Chlorophyllin monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
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Aloe 41 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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