Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Endothelial Defense Pomegranate Complete Ingredients & Drug Interactions

by Life Extension

Endothelial Defense Pomegranate Complete label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Endothelial Defense Pomegranate Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Endothelial Defense Pomegranate Complete is a dietary supplement by Life Extension with 6 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate 5:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Endothelial Defense Pomegranate Complete by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Endothelial Defense Pomegranate Complete by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Endothelial Defense Pomegranate Complete by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 ingredients, three of which are pomegranate-based: a pomegranate 5:1 extract, Pomella pomegranate extract, and a proprietary pomegranate blend. These deliver polyphenol antioxidants thought to support the inner lining of blood vessels (the endothelium).

The other two active ingredients—Superoxide Dismutase/Gliadin Complex and Cardiose Flavonoid Glycoside—appear as supporting compounds, though we don't have detailed interaction data on them. The softgels also contain inactive ingredients (extra virgin olive oil, gelatin, maltodextrin, glycerin, sunflower lecithin, purified water, carob color, and beeswax) that serve as carriers, binders, and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Endothelial and cardiovascular health support.
  • We looked for evidence on: Atherosclerosis, Coronary heart disease (CHD), Hyperlipidemia, Hypertension, Metabolic syndrome, Stroke — and 3 related terms.
  • The strongest evidence on file: Pomegranate is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Pomegranate is rated "Possibly Ineffective" for Hyperlipidemia.
  • Also on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Coronary heart disease (CHD), Stroke, Metabolic syndrome.

The data supports pomegranate as possibly effective for high blood pressure (hypertension). For cholesterol (hyperlipidemia), the evidence rates it as possibly ineffective—pomegranate hasn't shown it helps lower cholesterol levels.

For diabetes and nonalcoholic fatty liver disease, the evidence is either possibly ineffective or too limited to rate. If you're taking this product for blood pressure support, monitor your readings, especially if you're also on blood pressure medication.

The evidence, ingredient by ingredient Pomegranate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pomegranate fruit and juice are generally well tolerated as food. The extracts in this product also appear well tolerated in clinical use.

The most common side effects are mild gastrointestinal ones: diarrhea and flatulence affected about 2% of people taking pomegranate juice and up to 10% taking high-dose extract. A small number of trial participants also reported nausea, abdominal pain, constipation, and vomiting.

Since this is a concentrated extract supplement (not just juice), the caution here is that we have limited safety data on long-term use of this form, so proceed with care and watch for stomach upset. For pregnancy and lactation, the safety data rates pomegranate as possibly safe, though information is limited.

Talk with your doctor or pharmacist about whether it's right for you during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Pomegranate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pomegranate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 923 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood thinners like warfarin, blood pressure medications, ACE inhibitors, statins (especially rosuvastatin), antidepressants, antipsychotics, heart medications that go through CYP2D6 metabolism, or carbamazepine. Moderate and minor interactions are documented across all these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Endothelial Defense Pomegranate Complete is generally well tolerated and shows promise for blood pressure. However, if you take blood thinners, blood pressure medications, ACE inhibitors, statins, antidepressants, or any other prescription drug, you need to check your specific medications with your doctor or pharmacist before starting—the pomegranate content interacts with hundreds of drugs.

Don't combine this with warfarin without medical oversight.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Endothelial Defense Pomegranate Complete, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870209768
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 210815
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Endothelial Defense Pomegranate Complete by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
737870209768
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates1.5 Gram(s)1%
Calories from Fat15 Calorie(s)--
Total Fat1.5 Gram(s)2%
Protein1 Gram(s)1%
Pomegranate 5:1 extract100 mg--
Pomella Pomegranate extract400 mg--
Proprietary Pomegranate Blend137.5 mg--
Superoxide Dismutase/Gliadin Complex500 mg--
Cardiose Flavonoid Glycoside500 mg--

Other ingredients: extra virgin Olive Oil, Gelatin, Maltodextrin, Glycerin, Sunflower Lecithin, purified Water, Carob color, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow directions carefully prior to use. Directions: Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner.

Precautions

Caution: Do not take this product if you are allergic to wheat or gluten.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

Contains wheat

When using nutritional supplements, please consult with your physician if you are undergoing treatment or if you are pregnant or lactating.

Formulation

Non-GMO

Comprehensive support for nitric oxide production and vascular health

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Cardiose is a registered trademark of INTERQUIM, S.A. d.b.a. Ferrer HealthTech. POMELLA Extract is covered under U.S. Patent 7,638,640 and POMELLA is a registered trademark of Verdure Sciences, Inc. Isocell SA, France is the owner of US Patents Nos. 6,045,809 and 6,426,068B1 and trademark of GilSODin.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Endothelial Defense Pomegranate Complete by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Endothelial Defense Pomegranate Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Endothelial Defense Pomegranate Complete by Life Extension

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Pomegranate 5:1 extract

Interacts with
922 drugs
100 mg per serving

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate 5:1 extract monograph & interactions

Pomella Pomegranate extract

Interacts with
922 drugs
400 mg per serving Form: Punicalagins

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomella Pomegranate extract monograph & interactions

Proprietary Pomegranate Blend

Interacts with
922 drugs
137.5 mg per serving Form: Punicic Acid

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Proprietary Pomegranate Blend monograph & interactions

Superoxide Dismutase/Gliadin Complex

500 mg per serving

Cardiose Flavonoid Glycoside

500 mg per serving Form: Immature Sweet Orange, Rutinoside

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Maltodextrin, Glycerin, Sunflower Lecithin, Purified Water, Carob color, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Endothelial Defense Pomegranate Complete by Life Extension Drug Interactions

Want to check YOUR meds against Endothelial Defense Pomegranate Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
922Drugs
355 Moderate 567 Minor

Ingredients driving the most interactions

Pomegranate 5:1 extract 922

Individual Drug Interactions

The ingredients in Endothelial Defense Pomegranate Complete interact with 922 drugs. Click any drug to see the details.

1 of the 6 ingredients in Endothelial Defense Pomegranate Complete interact with drugs. Each result below shows which ingredient is responsible. Pomegranate 5:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Endothelial Defense Pomegranate Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate 5:1 extract9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate 5:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Endothelial Defense Pomegranate Complete, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Endothelial Defense Pomegranate Complete by Life Extension: Common Questions

Does Endothelial Defense Pomegranate Complete by Life Extension interact with any medications?
Yes. Based on its ingredients, Endothelial Defense Pomegranate Complete has a known interaction with 922 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Endothelial Defense Pomegranate Complete contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this pomegranate supplement lower my blood pressure?
The data rates pomegranate as possibly effective for high blood pressure. That means some people may see modest benefit, but it's not proven in everyone. If you're already on blood pressure medication, don't rely on this to do the work—and check with your doctor first, because combining them could drop your pressure too much.
Can I take this if I'm on a statin like rosuvastatin?
Not safely without talking to your doctor first. There's a documented case of muscle damage (rhabdomyolysis) in someone taking rosuvastatin and pomegranate juice together. Your doctor needs to know you're considering this and may want to monitor you or suggest an alternative.
What's in this besides pomegranate?
Two additional active ingredients—Superoxide Dismutase/Gliadin Complex and Cardiose Flavonoid Glycoside—plus inert carriers like olive oil, gelatin, and glycerin. We don't have detailed interaction data on those two compounds, so mention them to your pharmacist if you have concerns.
Is it safe to take while breastfeeding?
The data rates pomegranate as possibly safe during lactation, but information is limited. Talk with your doctor or pharmacist about your individual situation before taking it while breastfeeding.
What side effects should I watch for?
The most common are mild digestive issues—diarrhea and flatulence. A smaller number of people have reported nausea, stomach pain, constipation, and vomiting, especially at higher doses. If stomach upset starts, cut back or stop and tell your pharmacist.
Does this product actually help with cholesterol?
The data rates pomegranate as possibly ineffective for lowering cholesterol. If that's your goal, this product isn't the evidence-backed choice—talk with your doctor about options that are proven to work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Endothelial Defense Pomegranate Complete is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Endothelial Defense Pomegranate Complete label
Go deeper

The Full Monographs Behind Endothelial Defense Pomegranate Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph →
Sources

Sources & How We Checked

Endothelial Defense Pomegranate Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pomegranate 27 references
  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
  5. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
  6. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
  8. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
  9. Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
  10. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
  11. Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
  12. Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
  13. Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
  14. Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
  15. Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed
  16. Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
  17. Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther PubMed
  18. Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J 2010;27:74-5. PubMed
  19. Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151. PubMed
  20. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study PubMed
  21. Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
  22. Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.
  23. Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
  24. Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Clin Pharmacol Ther 2012;92(5):651-7. PubMed
  25. Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. PubMed
  26. Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. PubMed
  27. Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. PubMed

See these in context on the Pomegranate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team