Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Enzyme Forte Ingredients & Drug Interactions

by Foster Regal

Enzyme Forte label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enzyme Forte against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enzyme Forte is a dietary supplement by Foster Regal with 6 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Enzyme Forte by Foster Regal

Ask about any prescription or over-the-counter medication and we check it for interactions with Enzyme Forte by Foster Regal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Enzyme Forte by Foster Regal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (175 mg) without saying how much of each component you get.

Enzyme Forte contains 6 active ingredients, each a digestive enzyme or enzyme-like substance. Amylase, protease, and lipase are enzymes that help break down carbohydrates, proteins, and fats respectively.

Cellulase breaks down plant cell walls, and pancreatin is a blend of multiple pancreatic enzymes. Bile extract supports fat digestion and absorption.

The product also contains inactive ingredients — calcium phosphate, vegetable stearic acid, vegetable cellulose, silica, and vanillin — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Wound healing, Indigestion, Bloating and gas, Protein digestion.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for papain's effectiveness for the conditions listed — including cancer, dental problems, shingles, muscle soreness, and parasitic infections — is insufficient to rate. Similarly, lipase's effectiveness for inflammatory bowel disease and indigestion (dyspepsia) is not established in our data.

No effectiveness ratings are on file for amylase, protease, cellulase, or bile extract.

The evidence, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as food but may irritate your digestive tract or trigger allergic reactions in sensitive people — watch for itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. High doses of papain can cause serious problems like a torn esophagus or severe stomach inflammation.

Protease and lipase are generally well tolerated for most adults but may cause digestive upset or allergic reactions. None of these enzymes should be used during pregnancy unless your doctor advises it; there isn't enough safety data to recommend them while breastfeeding without medical guidance.

Protease and lipase may occasionally trigger respiratory allergies in people exposed to airborne enzyme dust at work.

Side effects, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, double-check before using this product — papain may increase its effects and your bleeding risk. For the other ingredients we could check, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Enzyme Forte is designed for digestive support and is generally well tolerated at normal doses. If you take warfarin or any blood thinner, check with your pharmacist before starting — papain can affect how warfarin works.

If you have serious digestive conditions or are pregnant or breastfeeding, talk to your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzyme Forte, straight from the product label.

Brand Foster Regal
Barcode (UPC) 364175115250
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 259928
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzyme Forte by Foster Regal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
250
UPC/BARCODE
364175115250
IngredientAmount% DV
Amylase0 NP--
Papain65 mg--
Protease0 NP--
Lipase0 NP--
Cellulase6 mg--
Pancreatin175 mg--
Bile extract100 mg--

Other ingredients: Calcium Phosphate, Vegetable Stearic Acid, Vegetable Cellulose, Silica, Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a food enzyme dietary supplement, take 1 tablet with each meal and if necessary at bedtime. Don't hesitate to use two servings (two tablets) with each meal and at bedtime if needed.

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Keep out of reach of children.

Contains milk ingredients.

Formula

Mfg. in a Ko Kosher Certified, FDA Registered Facility using Good Manufacturing Practices (GMPs)

Pancreatin containing protease, amylase and lipase with cellulase, papain and bile extract

Formulation

Mfg. in a Ko Kosher Certified, FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Nutritionally supports digestive health

Gluten free

Made in USA

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

The best choice

FDA Statement of Identity

Food Enzyme Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enzyme Forte by Foster Regal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enzyme Forte label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enzyme Forte by Foster Regal

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container250 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
65 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Cellulase

6 mg per serving

Pancreatin

175 mg per serving

Bile extract

100 mg per serving

Other (inactive) ingredients: Calcium Phosphate, Vegetable Stearic Acid, Vegetable Cellulose, Silica, Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzyme Forte by Foster Regal Drug Interactions

Want to check YOUR meds against Enzyme Forte?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Enzyme Forte interact with 2 drugs. Click any drug to see the details.

1 of the 6 ingredients in Enzyme Forte interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzyme Forte with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enzyme Forte, from the product label.

Foster Regal

See all Foster Regal products
Name
Foster Regal Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Enzyme Forte by Foster Regal: Common Questions

Does Enzyme Forte by Foster Regal interact with any medications?
Yes. Based on its ingredients, Enzyme Forte has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzyme Forte contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does papain in this product work for cancer, muscle soreness, or shingles?
The evidence isn't established. Our data shows insufficient reliable evidence to rate papain for cancer, exercise-induced muscle soreness, shingles, and several other conditions, so we can't tell you whether it will help.
What should I watch for if I take this product?
Most common side effects are allergic reactions — itchy or watery eyes, runny nose, sneezing, stomach cramps, or diarrhea. High doses may cause serious stomach problems. Stop and tell your pharmacist if you develop severe stomach pain or have trouble swallowing.
Can I take this while pregnant or breastfeeding?
Papain should be avoided in pregnancy because of safety concerns with concentrated forms. For protease and lipase, there isn't enough safety data, so check with your doctor or pharmacist — they can advise you based on your situation.
Is this product safe for people with digestive conditions?
People with serious digestive problems should use Enzyme Forte only under medical guidance. Talk to your doctor before starting, especially if you have conditions like inflammatory bowel disease.
What do these enzymes do?
Amylase, protease, and lipase break down carbs, proteins, and fats to help your body digest food. Cellulase breaks down plant fiber, pancreatin adds multiple pancreatic enzymes, and bile extract supports fat digestion.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzyme Forte is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzyme Forte label
Go deeper

The Full Monographs Behind Enzyme Forte’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Enzyme Forte's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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