Interactions on record — worth a quick check against your medications. Based on 5 of 15 ingredients. Check your meds →
Dietary supplement

Enzymes Ingredients & Drug Interactions

by Smarter Nutrition

Enzymes label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enzymes is a dietary supplement by Smarter Nutrition with 15 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Enzymes by Smarter Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Enzymes by Smarter Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Enzymes by Smarter Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “Smarter Enzymes Blend” is a proprietary blend — the label gives one combined amount (350 mg) without saying how much of each component you get.

Smarter Nutrition Enzymes contains 15 active ingredients, most of them digestive enzymes that help break down food. Papain comes from papaya and breaks down proteins; bromelain comes from pineapple and does the same.

Lactase helps digest milk sugar if you're sensitive to lactose. Lipase breaks down fats, while protease and other enzymes (cellulase, hemicellulase, amylase, maltase, invertase, serratiopeptidase, alpha galactosidase, beta glucanase, and glucomylase) work on different parts of your food.

The formula also includes AstraGin, a nutrient absorption enhancer. The capsule and other ingredients are vegetarian and made from organic rice bran, rice extract, and nu-flow.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: nutrient absorption and digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Lactose intolerance, Postoperative swelling, Rhinosinusitis, Sprains — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most of these enzymes is limited. Lactase is rated effective for lactose intolerance — if you have trouble digesting milk sugar, this one works.

For the others, including papain, bromelain, lipase, and protease, we don't have reliable evidence they work for their intended uses like improving digestion, reducing inflammation, or easing muscle soreness. That doesn't mean they don't help; it means the science isn't there yet in our data.

The evidence, ingredient by ingredient Papain Bromelain Lactase Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These enzymes are generally well tolerated when taken at normal doses. Papain may irritate your digestive tract or trigger allergic reactions in sensitive people — symptoms can include itchy eyes, runny nose, sneezing, stomach cramps, or diarrhea.

Bromelain can cause similar digestive upset (diarrhea, gas, nausea) and skin reactions like itching or hives, especially if you're allergic to pineapple. Protease is also generally well tolerated but may cause digestive upset or allergic reactions in some people.

High doses of papain are risky and may cause serious damage to your esophagus and stomach. For pregnancy: papain is rated possibly unsafe — concentrated papain and unripe papaya products are best avoided.

Bromelain and protease are also best avoided in pregnancy because safety data is lacking. Lactase is rated likely safe in pregnancy.

For breastfeeding: papain and bromelain lack enough safety data, so avoid them; protease also lacks data and is not recommended without medical advice. Lactase is likely safe while breastfeeding.

Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Papain Bromelain Lactase Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Smarter Nutrition Enzymes, double-check with your doctor or pharmacist if you take any blood thinners or anticoagulants (like warfarin, apixaban, or dabigatran) — papain and bromelain may increase your bleeding risk. Also check if you take antiplatelet drugs like aspirin or clopidogrel.

If you're on a tetracycline antibiotic, bromelain may affect how much of it your body absorbs, so confirm that's okay too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme blend may help with lactose digestion, but the evidence for the other enzymes isn't established in our data. If you take blood thinners or antiplatelet drugs, you'll want to check this formula with your doctor or pharmacist first, since papain and bromelain may increase bleeding risk.

Most people tolerate these enzymes well, but if you have a sensitive stomach or a known allergy to papaya or pineapple, be cautious. Chat with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzymes, straight from the product label.

Brand Smarter Nutrition
Barcode (UPC) 857917007130
Net contents 90 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 268688
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzymes by Smarter Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
857917007130
IngredientAmount% DV
Papain0 NP--
Bromelain0 NP--
Lactase0 NP--
Lipase0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Amylase0 NP--
Maltase0 NP--
Invertase0 NP--
Serratiopeptidase0 NP--
AstraGin25 mg--
Alpha Galactosidase0 NP--
Beta Glucanase0 NP--
Glucomylase0 NP--
Protease0 NP--
Smarter Enzymes Blend350 mg--

Other ingredients: Vegetarian Capsule, organic Rice Bran, organic Nu-Flow, organic Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Smarter is better Smarter is efficient Enzymes break down food to be absorbed and used by the body. Unfortunately, enzyme production decreases with age resulting in poor nutrient absorption. Smarter is complete Different types of foods require different enzymes. A full spectrum of enzymes are important to break down various starches, proteins, complex fibers, carbohydrates, and fats.

Formulation

Smarter delivers We've even added clinically proven support ingredients to help the body increase the uptake of nutrients at the cellular level.

Nutrient absorption Enhanced with plant extracts proven to help with the absorption of nutrients

This product does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, or soy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1-2 capsules directly after each meal, or as recommended by your healthcare provider.

Precautions

Caution: As with any dietary supplement, consult your healthcare provider before using this product, especially if pregnant, nursing, taking medications, or under medical supervision.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2020 Smarter Nutrition All Rights Reserved AstraGin AstraGin is a registered trademark of NuLiv Science USA Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enzymes by Smarter Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enzymes by Smarter Nutrition

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

AstraGin

25 mg per serving Form: Astragalus membranaceous, Panax notoginseng

Smarter Enzymes Blend

350 mg per serving
  • › Papain
  • › Bromelain
  • › Lactase
  • › Lipase
  • › Cellulase
  • › Hemicellulase
  • › Amylase
  • › Maltase
  • › Invertase
  • › Serratiopeptidase
  • › Alpha Galactosidase
  • › Beta Glucanase
  • › Glucomylase
  • › Protease

Other (inactive) ingredients: Vegetarian Capsule, Organic Rice Bran, Organic Nu-Flow, Organic Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzymes by Smarter Nutrition Drug Interactions

Want to check YOUR meds against Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Enzymes interact with 141 drugs. Click any drug to see the details.

2 of the 15 ingredients in Enzymes interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enzymes, from the product label.

Smarter Nutrition

See all Smarter Nutrition products
Name
Smarter Nutrition, Inc
Street Address
17870 Newhope St Ste 104 #480
City
Fountain Valley
State
CA
ZipCode
92708
Pharmacist Counseling Corner

Enzymes by Smarter Nutrition: Common Questions

Does Enzymes by Smarter Nutrition interact with any medications?
Yes. Based on its ingredients, Enzymes has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzymes contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with digestion?
These enzymes are designed to break down food, but we don't have strong evidence they improve digestion or ease digestive discomfort in our data. Lactase is proven to help if you have trouble digesting milk, but the evidence for the others isn't established yet.
Can I take this if I'm allergic to pineapple or papaya?
No. Bromelain comes from pineapple and papain from papaya — if you're allergic to either fruit, you're likely allergic to these enzymes too and should avoid this product. Allergic reactions can range from itching and hives to serious breathing problems.
Is it safe during pregnancy?
No. Papain is rated possibly unsafe in pregnancy, and bromelain and protease lack enough safety data to use without your doctor's go-ahead. Lactase is likely safe, but since this is a blend, talk with your doctor or pharmacist first.
Can this cause diarrhea or stomach upset?
Yes, it's possible. Bromelain commonly causes diarrhea, gas, and stomach upset in some people. Papain may irritate your digestive tract, and protease can cause similar issues. High doses of papain are especially risky and may cause serious stomach or esophageal damage.
What are these enzymes supposed to do?
They break down different parts of food — papain and protease break down protein, bromelain breaks down protein, lipase breaks down fat, and lactase breaks down milk sugar. The others break down carbohydrates and fiber to help your body process what you eat.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzymes label
Go deeper

The Full Monographs Behind Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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