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Dietary supplement

Extra Strength Bilberry 1000 mg Ingredients & Drug Interactions

by Nature's Bounty

Extra Strength Bilberry 1000 mg label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra Strength Bilberry 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra Strength Bilberry 1000 mg is a dietary supplement by Nature's Bounty with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Extra Strength Bilberry 1000 mg by Nature's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Bilberry 1000 mg by Nature's Bounty — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Extra Strength Bilberry 1000 mg by Nature's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bilberry fruit extract at 1000 mg per softgel capsule. Bilberry is a small dark berry long used in folk medicine, and the extract concentrates its anthocyanidin compounds — the pigments thought to be responsible for its effects.

The softgel also includes soybean oil, gelatin, vegetable glycerin, soy lecithin, beeswax, and caramel color as inactive ingredients to hold and deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy eye function.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence for bilberry's effectiveness is mixed and limited. For night vision — perhaps its best-known use — the data suggests it's likely ineffective.

For age-related cognitive decline, age-related macular degeneration (AMD), atherosclerosis, high cholesterol (hyperlipidemia), and chronic venous insufficiency, the evidence we hold is insufficient to rate whether it works. If you're considering bilberry for any of these, talk with your doctor about what the current science actually supports.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as food is generally safe, but concentrated supplements have limited long-term safety data. The safety notes advise caution with supplement doses due to lack of reliable information.

Most people who take bilberry tolerate it well orally. The most common side effects are dark-colored stools (which can be striking — some people report dark green or bluish-black stools), flatulence, and mild stomach upset.

In small trials, about one-third of people taking concentrated bilberry products reported mild-to-moderate gas, and about 13% reported temporary digestive discomfort. Slight discoloration of the tongue and rarely the teeth has also been observed.

These effects are usually temporary and minor.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticoagulants or antiplatelet drugs (blood thinners like warfarin or aspirin), antidiabetes medications, drugs metabolized by the CYP2E1 liver enzyme, or erlotinib (Tarceva), double-check this product with your doctor or pharmacist before you start — bilberry may affect how these work or increase your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Extra Strength Bilberry may be worth considering if you're looking for a supplement with a long history of use, but the evidence that it actually works for common purposes like night vision or cognitive decline is weak or absent. If you take blood thinners, diabetes medications, or erlotinib, check with your doctor or pharmacist before starting — bilberry may interact with these.

Most people tolerate it well, though dark stools and gas are common. Talk it over with your own healthcare provider to see if it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra Strength Bilberry 1000 mg, straight from the product label.

Brand Nature's Bounty
Barcode (UPC) 074312014185
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4234
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra Strength Bilberry 1000 mg by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
074312014185
IngredientAmount% DV
Bilberry1000 mg--

Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Soy Lecithin, yellow Beeswax, natural Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

HERBAL SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) softgel once or twice daily, preferably with a meal.

Precautions

Keep out of reach of children.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if seal under cap is broken or missing.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

General Statements

1000mg equivalent per softgel** Concentrated Extract

Bilberry is a close relative of the blueberry, and is known for its dark purple color. Bilberry naturally contains Anthocyanosides and helps to support healthy eye function.*

Promotes Healthy Eye Vision*

RAPID RELEASE LIQUID SOFTGEL

General

Prod. No. 1418 01B B1431

Brand IP Statement(s)

(C) 2010 Nature’s Bounty, Inc.

Nutrition Questions or Comments? Call NutraPhone(R) 1-800-433-2990 Mon. - Fri. 9 AM - 7 PM ET

Formulation

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Seals/Symbols

(recycle) Healthy you Healthy earth

LABORATORY TESTED GUARANTEED QUALITY

NATURE'S BOUNTY(R)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra Strength Bilberry 1000 mg by Nature's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra Strength Bilberry 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra Strength Bilberry 1000 mg by Nature's Bounty

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Bilberry

Interacts with
275 drugs
1000 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Soy Lecithin, Yellow Beeswax, Natural Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra Strength Bilberry 1000 mg by Nature's Bounty Drug Interactions

Want to check YOUR meds against Extra Strength Bilberry 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry 275

Individual Drug Interactions

The ingredients in Extra Strength Bilberry 1000 mg interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Extra Strength Bilberry 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra Strength Bilberry 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra Strength Bilberry 1000 mg, from the product label.

Nature's Bounty

See all Nature's Bounty products
Web Address
www.NaturesBounty.com
Pharmacist Counseling Corner

Extra Strength Bilberry 1000 mg by Nature's Bounty: Common Questions

Does Extra Strength Bilberry 1000 mg by Nature's Bounty interact with any medications?
Yes. Based on its ingredients, Extra Strength Bilberry 1000 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra Strength Bilberry 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does bilberry actually help with night vision?
The evidence suggests it's likely ineffective for night vision, despite its reputation. For the other conditions bilberry is sometimes used for — like age-related macular degeneration or cognitive decline — we don't have enough reliable data to say whether it works.
What are the most common side effects?
Dark-colored stools (sometimes dark green or nearly black), gas, and mild stomach discomfort are most common. These are usually temporary and not serious. A small number of people may also notice slight discoloration of the tongue.
Is it safe if I'm pregnant or nursing?
Bilberry is rated likely safe in pregnancy and lactation, but supplement doses are different from food amounts. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or breastfeeding.
Can I take this with my blood thinner?
Bilberry may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Don't start this without checking with your doctor or pharmacist first — they can assess the risk based on your specific situation.
What's actually in this supplement besides bilberry?
The active ingredient is bilberry fruit extract. The capsule also contains soybean oil, gelatin, vegetable glycerin, soy lecithin, beeswax, and caramel color — these are inactive ingredients that help deliver and preserve the extract.
Is there a lot of safety data on bilberry supplements?
Bilberry fruit as food has a long history of use, but concentrated supplements haven't been studied extensively for long-term safety. Most people who take it tolerate it well, but we don't have as much safety information as we do for some other supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra Strength Bilberry 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra Strength Bilberry 1000 mg label
Go deeper

The Full Monographs Behind Extra Strength Bilberry 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Extra Strength Bilberry 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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