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Dietary supplement

Fadogia Agrestis with Tongkat Ali Ingredients & Drug Interactions

by aSquared Nutrition

Fadogia Agrestis with Tongkat Ali label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fadogia Agrestis with Tongkat Ali against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fadogia Agrestis with Tongkat Ali is a dietary supplement by aSquared Nutrition with 2 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Fadogia Agrestis with Tongkat Ali by aSquared Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.
  • “Fadogia agrestis Extract” is listed as a grouped ingredient — the label gives one combined amount (600 mg) without saying how much of each component you get.

This supplement contains two active ingredients. Fadogia agrestis stem extract is included for potential benefits, though the evidence for athletic performance, erectile dysfunction, and malaria is not yet reliable enough to rate.

Tongkat Ali root extract (also called Eurycoma longifolia) is the second ingredient — it has possibly effective evidence for sexual desire, though it appears possibly ineffective for athletic performance. The capsules also contain inactive ingredients: cellulose, silicon dioxide, and magnesium stearate, which are common binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Eurycoma Longifolia) (Natural Medicines).

The evidence for what this product can actually do is mixed and often weak. Tongkat Ali shows possibly effective evidence for sexual desire — meaning there's some clinical support, but it's not conclusive.

For athletic performance, the evidence for Tongkat Ali rates as possibly ineffective. For other uses listed — back pain, osteoporosis, and diabetes with Tongkat Ali, plus athletic performance, erectile dysfunction, and malaria with Fadogia agrestis — we don't have enough reliable evidence to rate whether they work.

Talk with your pharmacist about what you're hoping to achieve, and whether this product's evidence matches your goal.

The evidence, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients come with safety cautions. Fadogia agrestis is the bigger concern: human safety data are lacking, and animal studies raise questions about possible toxicity to the testicles, liver, and kidneys.

Tongkat Ali is generally well tolerated in short-term studies, but long-term safety is uncertain and product quality varies. Because Tongkat Ali may increase testosterone levels, there's a risk of testosterone-related side effects like acne, insulin resistance, and liver injury if your testosterone goes beyond the normal range.

For pregnancy and breastfeeding, Fadogia agrestis should be avoided — no safety data exist. Tongkat Ali should also be avoided in pregnancy due to possible hormonal effects, and while breastfeeding there isn't enough reliable safety information.

Side effects, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on propranolol (Inderal) or any other blood pressure or heart medication — Tongkat Ali can lower its effectiveness. Additionally, check any medications processed through liver enzymes (CYP1A2, CYP2C19, or CYP2A6 substrates — your pharmacist can tell you if yours are) and any testosterone-boosting treatments.

Fadogia agrestis was not checked for interactions with medications in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is marketed for sexual desire and athletic performance, but the evidence is limited — Tongkat Ali shows possibly effective support only for sexual desire. Both ingredients raise safety concerns, especially Fadogia agrestis with its animal toxicity signals.

If you take blood pressure medications or any drugs processed by your liver, you need to check this with your pharmacist before starting. Pregnant or breastfeeding?

Skip it entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fadogia Agrestis with Tongkat Ali, straight from the product label.

Brand aSquared Nutrition
Barcode (UPC) X003SQRXU9
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 322070
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fadogia Agrestis with Tongkat Ali by aSquared Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
X003SQRXU9
IngredientAmount% DV
Fadogia agrestis Stem Extract0 NP--
Tongkat Ali root extract400 mg--
Fadogia agrestis Extract600 mg--

Other ingredients: Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules per day with a meal, or as directed by your qualified healthcare professional.

Precautions

Caution: Do not exceed the recommended dose. Do not use if safety seal is damaged or missing.

Not for use by children under 18 years of age. Keep out of the reach of children.

Pregnant or nursing mothers, individuals taking any medications, individuals with a known medical condition, and individuals planning a medical procedure should consult a physician before using this or any dietary supplement.

Seals/Symbols

Sourced from a GMP Certified Facility Good Manufacturing Practice Certified Facility

USA Formulated

Third-party tested High quality supplement

General Statements

Please recycle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Formulation

Ultra strength Supports energy levels

No preservatives

Formula

Enhanced with Tongkat Ali

aSquared Nutrition is proud to offer an ultra-strength Fadogia agrestis supplement enhanced with Tongkat Ali. Our formula contains 600mg of Fadogia agrestis and 400mg of Tongkat Ali per serving.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fadogia Agrestis with Tongkat Ali label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tongkat Ali root extract

Interacts with
248 drugs
400 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali root extract monograph & interactions

Fadogia agrestis Extract

No known
interactions
600 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestis Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition Drug Interactions

Want to check YOUR meds against Fadogia Agrestis with Tongkat Ali?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali root extract 248

Individual Drug Interactions

The ingredients in Fadogia Agrestis with Tongkat Ali interact with 248 drugs. Click any drug to see the details.

1 of the 2 ingredients in Fadogia Agrestis with Tongkat Ali interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fadogia Agrestis with Tongkat Ali with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali root extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fadogia Agrestis with Tongkat Ali, from the product label.

aSquared Nutrition

See all aSquared Nutrition products
Name
aSquared Brands LLC
Street Address
382 NE 191st Street, #98406
City
Miami
State
Florida
ZipCode
33179
Phone Number
1-800-557-4120
Pharmacist Counseling Corner

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition: Common Questions

Does Fadogia Agrestis with Tongkat Ali by aSquared Nutrition interact with any medications?
Yes. Based on its ingredients, Fadogia Agrestis with Tongkat Ali has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fadogia Agrestis with Tongkat Ali contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
No. Fadogia agrestis should be avoided in pregnancy and while breastfeeding because there's no safety data. Tongkat Ali should also be avoided in pregnancy due to possible hormonal effects, and while breastfeeding the safety information isn't reliable enough. Talk to your obstetrician or pharmacist before considering it.
What is Fadogia agrestis supposed to do?
It's marketed for athletic performance, erectile dysfunction, and malaria, but the evidence for all three is insufficient — we don't have enough reliable data to say whether it actually works. Additionally, animal studies suggest it may be toxic to your testicles, liver, and kidneys, so caution is needed.
Does Tongkat Ali really improve athletic performance?
The evidence suggests it's possibly ineffective for that use. It does show possibly effective evidence for sexual desire, but not for athletic performance specifically.
Can this product raise my testosterone?
Tongkat Ali may increase testosterone levels — clinical studies show an 8% increase in men with low testosterone. If your levels go beyond normal, that can bring side effects like acne, insulin resistance, and liver injury, so this matters if you're already on testosterone treatment.
Is this safe to take long-term?
The safety data don't support long-term use. Tongkat Ali is generally well tolerated in the short term in studies, but long-term safety is uncertain, and product quality varies. Fadogia agrestis has even less safety data and animal studies suggest possible toxicity to organs.
Will this interfere with my blood pressure medicine?
Yes, if you take propranolol (Inderal). Tongkat Ali can reduce how well propranolol works — a study showed it lowered propranolol levels by about 29%. If you take any blood pressure or heart medication, check with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fadogia Agrestis with Tongkat Ali is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fadogia Agrestis with Tongkat Ali label
Go deeper

The Full Monographs Behind Fadogia Agrestis with Tongkat Ali’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph →
Sources

Sources & How We Checked

Fadogia Agrestis with Tongkat Ali's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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