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Dietary supplement

Fennel & Wild Yam Combination Chocolate Flavor Ingredients & Drug Interactions

by TerraVita

Fennel & Wild Yam Combination Chocolate Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fennel & Wild Yam Combination Chocolate Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fennel & Wild Yam Combination Chocolate Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 740 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel & Wild Yam Combination Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fennel & Wild Yam Combination Chocolate Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Fennel & Wild Yam Combination Chocolate Flavor by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fennel & Wild Yam Combination Chocolate Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Fennel & Wild Yam Combination Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

This liquid contains two active ingredients: fennel glycerite liquid extract and wild yam glycerite liquid extract. Fennel is traditionally used for digestive comfort and has been studied for menstrual cramping (dysmenorrhea), though the evidence is limited for other conditions like anxiety and bronchitis.

Wild yam root is often marketed for menopausal symptoms, but the data we hold suggests it's likely ineffective for that use and lacks solid evidence for sexual dysfunction or menstrual discomfort. The product also contains glycerin (a sweetener and preservative) and chocolate flavor as inactive ingredients — these are excipients that help with taste and shelf life but aren't the active therapeutic components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dysmenorrhea — rated "Possibly Effective" (Fennel) (Natural Medicines).

For fennel, the strongest evidence is for dysmenorrhea (menstrual cramping) — it's rated possibly effective. The evidence for its use in bronchitis, anxiety, nocturnal bed-wetting, and cholera isn't established in our data.

For wild yam, the picture is less encouraging. It's rated possibly ineffective for menopausal symptoms — the condition it's most often sold for — and the evidence for gallbladder disease, sexual dysfunction, menstrual cramping, and infertility isn't established in our data either.

The evidence, ingredient by ingredient Fennel Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel is generally well tolerated when eaten as food, but concentrated supplements and essential oils need more caution. Most people don't experience problems, though some report gastrointestinal discomfort, sun sensitivity, or allergic reactions — rarely, seizures have been reported.

Wild yam is generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. Common side effects with wild yam include fever, headache, upset stomach, and vomiting, especially at higher doses; anaphylaxis is rare.

Both ingredients carry pregnancy and breastfeeding cautions. Fennel is rated possibly unsafe in pregnancy because of limited safety data and its hormone-like effects, and medicinal doses aren't well studied while breastfeeding — food amounts are likely fine.

Wild yam is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Fennel Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Fennel, Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 741 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (moderate risk of increased bleeding), birth control pills or hormone replacement therapy (moderate risk of reduced effectiveness), the antibiotic ciprofloxacin (moderate risk of reduced effectiveness), tamoxifen (moderate risk of reduced effectiveness), or any medications metabolized by the CYP3A4 enzyme in your liver (moderate risk of increased drug levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with menstrual cramping, though the evidence is modest, but it's not proven effective for most other uses. The real concern is medications: if you take blood thinners, birth control, hormone therapy, certain antibiotics, tamoxifen, or drugs processed by your liver, you need to check with your doctor or pharmacist before starting this.

Pregnancy and breastfeeding warrant a conversation with your healthcare provider too.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fennel & Wild Yam Combination Chocolate Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435224554
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281690
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fennel & Wild Yam Combination Chocolate Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435224554
IngredientAmount% DV
Fennel Glycerite Liquid Extract0 NP--
Wild Yam Glycerite Liquid Extract0 NP--
Fennel & Wild Yam Combination Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Chocolate flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5) Chocolate flavored

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fennel & Wild Yam Combination Chocolate Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fennel & Wild Yam Combination Chocolate Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fennel & Wild Yam Combination Chocolate Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Fennel & Wild Yam Combination Glycerite Liquid Extract

Interacts with
740 drugs
0.13 mL per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Fennel & Wild Yam Combination Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Chocolate flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fennel & Wild Yam Combination Chocolate Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Fennel & Wild Yam Combination Chocolate Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
740Drugs
740 Moderate

Ingredients driving the most interactions

Fennel & Wild Yam Combination Glycerite Liquid Extract 740

Individual Drug Interactions

The ingredients in Fennel & Wild Yam Combination Chocolate Flavor interact with 740 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fennel & Wild Yam Combination Chocolate Flavor interact with drugs. Each result below shows which ingredient is responsible. Fennel & Wild Yam Combination Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fennel & Wild Yam Combination Chocolate Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel & Wild Yam Combination Glycerite Liquid Extract6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel & Wild Yam Combination Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fennel & Wild Yam Combination Chocolate Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Fennel & Wild Yam Combination Chocolate Flavor by TerraVita: Common Questions

Does Fennel & Wild Yam Combination Chocolate Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Fennel & Wild Yam Combination Chocolate Flavor has a known interaction with 740 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fennel & Wild Yam Combination Chocolate Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Not without checking first. Fennel and wild yam both have estrogenic activity and theoretically may reduce how well your birth control works. Talk to your doctor or pharmacist before starting — they'll know your specific situation.
Is this safe during pregnancy?
No. Both fennel and wild yam are rated possibly unsafe in pregnancy because of limited safety data and fennel's hormone-like effects. Avoid this product if you're pregnant, and talk with your doctor or pharmacist if you're thinking about becoming pregnant.
What side effects might I experience?
Most people tolerate it well. Fennel may cause stomach discomfort, sun sensitivity, or allergic reactions in sensitive folks. Wild yam can cause fever, headache, upset stomach, or vomiting, especially at higher doses. Serious reactions are rare but possible.
Does this actually work for menstrual cramps?
Fennel is rated possibly effective for dysmenorrhea (menstrual cramping), so there's some evidence, though it's not strong. Wild yam doesn't have reliable evidence for this use.
Can I breastfeed while taking this?
Food amounts of fennel are likely fine, but medicinal doses aren't well studied while breastfeeding. Wild yam should be avoided entirely while breastfeeding due to insufficient safety data. Check with your doctor or pharmacist.
Will this help with menopausal symptoms?
Wild yam is often marketed for that, but the data we hold rates it possibly ineffective for menopausal symptoms. Fennel hasn't been reliably studied for this either.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fennel & Wild Yam Combination Chocolate Flavor label
Go deeper

The Full Monographs Behind Fennel & Wild Yam Combination Chocolate Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Fennel & Wild Yam Combination Chocolate Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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