Flexi-Smart Ingredients & Drug Interactions
by SuperSmart
What is this page for?
First and foremost: checking Flexi-Smart against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Flexi-Smart is a dietary supplement by SuperSmart with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Flexi-Smart by SuperSmart
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Flexi-Smart has three active ingredients. Hyaluronic Acid is a naturally occurring substance that holds moisture; it's used here for skin hydration and joint lubrication.
ApresFlex is frankincense, a resin extract traditionally used in skincare. The third ingredient, AvoVida, is also active in the formula, though we don't have detailed data on file for it.
The capsule also contains inactive ingredients — acacia gum and white rice flour — that help hold the formula together.
Does it work?
Not established
The evidence varies by ingredient and condition. Hyaluronic Acid shows possibly effective ratings for dry eye and venous leg ulcers (slow-healing wounds on the legs).
For aging skin, hay fever, and sexual dysfunction, the evidence we have on file is insufficient to rate it reliably. Frankincense (ApresFlex) has insufficient reliable evidence for acne, aging skin, back pain, cancer-related fatigue, and radiation skin damage — meaning we don't yet have strong data showing whether it works for these uses.
We have no established effectiveness data for AvoVida on file.
How safe is it?
Well-documented data
Hyaluronic Acid is generally well tolerated when taken by mouth or applied to skin, though long-term safety of oral supplements hasn't been fully studied. The safety data suggests caution and recommend avoiding oral supplements unless your doctor advises otherwise.
Topical use can rarely cause eczema, itching, redness, or skin infections; eye drops with hyaluronic acid have rarely caused eye pain. Frankincense is generally well tolerated short-term when applied to skin or inhaled, but product quality and dosing vary widely.
Safety data advises against use during pregnancy and while breastfeeding. Topical application can cause dermatitis, itching, or redness; allergic skin reactions are rare but have been reported.
We have no pregnancy or breastfeeding data on file for AvoVida.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, we weren't able to check AvoVida, so mention all three ingredients to your pharmacist or doctor before starting.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
If you're looking to support skin hydration or joint comfort, talk with your pharmacist first — the long-term safety of these ingredients as oral supplements isn't fully established. Pregnant or breastfeeding?
Frankincense in this product should be avoided. Run your medications through our checker to be sure, and let us know if you have questions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Flexi-Smart, straight from the product label.
| Brand | SuperSmart |
|---|---|
| Barcode (UPC) | 5453003825838 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 332363 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Flexi-Smart by SuperSmart, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hyaluronic Acid | 10 mg | -- |
| ApresFlex | 200 mg | -- |
| AvoVida | 600 mg | -- |
Other ingredients: Acacia Gum, White Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
ApresFlex is a registered trademark of : Laila Nutraceuticals exclusively licensed to PL Thomas. Laila Nutra LLC. International patents pending.
Formulation
Joint Health
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended use: Adults. Take two capsules a day.
Precautions
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used to replace a varied, balanced diet or healthy lifestyle.
Keep out of childrens' reach.
As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
Precautions: Contains soya derivatives.
Storage
Store away from direct light, heat and humidity.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Flexi-Smart by SuperSmart label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Flexi-Smart by SuperSmart
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hyaluronic Acid
No knowninteractions
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...
Hyaluronic Acid monograph & interactionsApresFlex
No knowninteractions
Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. E...
ApresFlex monograph & interactionsAvoVida
Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.
Flexi-Smart by SuperSmart Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Flexi-Smart. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Flexi-Smart, from the product label.
SuperSmart
See all SuperSmart products- Name
- SN Worldwide Unipessoal, LDA
- Street Address
- Avenida Do Infante 66 Edificio Quinta Avenida 1 C
- City
- Funchal
- ZipCode
- 9000-015
Flexi-Smart by SuperSmart: Common Questions
Does Flexi-Smart by SuperSmart interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
What's hyaluronic acid actually for in a supplement like this?
Is frankincense safe to take by mouth?
What are the most common side effects?
How long is it safe to take this supplement?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Flexi-Smart is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Flexi-Smart’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph → Herb & supplement monographFrankincense
Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...
Read the full Frankincense monograph →Sources & How We Checked
Flexi-Smart's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Frankincense 2 references
- Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
- Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC