FlexiJoint Formula Ingredients & Drug Interactions
by CATALO
What is this page for?
First and foremost: checking FlexiJoint Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
FlexiJoint Formula is a dietary supplement by CATALO with 4 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chondroitin Sulfate, Depolymerized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against FlexiJoint Formula by CATALO
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HelloPharmacist Scorecard of FlexiJoint Formula by CATALO
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
FlexiJoint Formula contains 8 active ingredients aimed at joint and skin health. The main components are hyaluronic acid (which your body uses to retain moisture in tissues), chondroitin sulfate (a carbohydrate that supports cartilage structure), hydrolyzed collagen type II (broken-down collagen that may be absorbed more easily), and a blend of cetylated fatty acids—compounds derived from plant and animal fats.
The formula also includes BioCell Collagen, a proprietary blend, and several other cetylated fatty acid compounds. The capsule itself is made with gelatin, rice powder, calcium phosphate, and other inactive ingredients like silicon dioxide and magnesium stearate, which help bind and form the capsule.
Does it work?
Moderate evidence
Evidence for these ingredients is mixed. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers, but evidence for aging skin and hay fever is insufficient.
Chondroitin sulfate is possibly effective for cataracts and osteoarthritis, though evidence for aging skin, osteoporosis, and high cholesterol is insufficient. For hydrolyzed collagen type II and the cetylated fatty acids, we don't hold effectiveness data in our records, so we can't say how well they work for joint or skin conditions.
How safe is it?
Well-documented data
Hyaluronic acid and chondroitin sulfate are generally well tolerated when taken by mouth. The most common side effects from chondroitin are mild: abdominal pain, bloating, constipation, diarrhea, heartburn, or nausea.
Rare serious effects include liver damage from chondroitin. Some people report skin symptoms like eyelid swelling, rash, or hair loss.
A few cases of asthma flare-ups and light sensitivity have been reported with chondroitin-glucosamine combinations. For pregnancy, the safety data advises against chondroitin—not enough information is available to recommend it during pregnancy or breastfeeding.
Hyaluronic acid's pregnancy and lactation data is incomplete in our records, so talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning pregnancy, or breastfeeding.
Meds to double-check
Moderate interaction found
If you take warfarin (Coumadin) or another blood thinner, pause and speak with your doctor or pharmacist before starting FlexiJoint Formula; chondroitin may strengthen the blood-thinning effect and raise your bleeding risk. For the other active ingredients in this formula, no interactions are documented for those we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
FlexiJoint Formula may help support joint and skin health if you're interested in hyaluronic acid and chondroitin, though the evidence is strongest for dry eye and osteoarthritis specifically. If you take warfarin or any blood thinner, check with your doctor or pharmacist before adding this supplement—chondroitin may increase bleeding risk.
Pregnant or breastfeeding? Talk with your healthcare provider first.
For everyone else, run your current medications through the tool on this page to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about FlexiJoint Formula, straight from the product label.
| Brand | CATALO |
|---|---|
| Net contents | 60 Capsule(s); 35.7 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 303086 |
| Product type | Fat/fatty Acid |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Seniors/Mature (>50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for FlexiJoint Formula by CATALO, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hyaluronic Acid | 36 mg | -- |
| Cetyl Myristoleate | 0 NP | -- |
| Cetyl Myristate | 0 NP | -- |
| Cetyl Palmitate | 0 NP | -- |
| Cetyl Oleate | 0 NP | -- |
| BioCell Collagen | 360 mg | -- |
| Collagen Type II, Hydrolyzed | 216 mg | -- |
| Chondroitin Sulfate, Depolymerized | 72 mg | -- |
| FlexiJoint Cetylated Fatty Acids Complex | 300 mg | -- |
| Cetylated Fatty Acids | 0 NP | -- |
| Cetyl Palmitoleate | 0 NP | -- |
Other ingredients: Rice, Powder, Gelatin, Calcium Phosphate, Rice Hull Concentrate, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Clinically proven ingredient
CATALO FlexiJoint formula offers a comprehensive joint care. This formula contains premium natural ingredients that support joint health against aging.
Made in USA
FDA Statement of Identity
Dietary Supplement
Formula
4 Premium natural ingredients 1 Proprietary cetylated complex formula, has been clinically proven to support healthy joint motion, promote joint mobility, flexibility and relieve joint pain. It has been shown to have dramatic result on relieving joint discomfort and accelerating joint recovery. 2 Hyaluronic acid (HA), enhances body to restore fluids that cushion bones and joints by increasing joint fluid and supporting cartilage synthesis in the joints thus lowering the chance for deterioration. 3 Hydrolyzed collagen type II, can restore joint cell membranes throughout the body, especially working in joints to maintain the fluids that cushion the end of the bone. As a result, the pain and discomfort are minimized. 4 Depolymerized chondroitin sulfate, smaller molecules of chondroitin sulfate enhance the absorption rate. It supports healthy joint function by strengthening cartilage and joint structure. Hesslink, R, Armstrong, D., & Nagendran M.V. et al. J Rheumatol, 2002;29;1708-12
Suitable for: Inflexible joints, unsmooth joint movement, engaged in vigorous exercise, joint degeneration, injured joint, joint pain, discomfort during weather change, people on high heels, elderly, overweight people
General Statements
Scan and discover more about this product!
Net weight 35.7 (595mg x 60 capsules)
Seals/Symbols
cGMP Current Good Manufacturing Practices Quality Efficacy - Natural - Potency - Safety
Suggested/Recommended/Usage/Directions
Serving directions For adults, take 2 capsules 1-2 times daily. Take with 250-300ml of water
Storage
Storage Keep in a dry and cool place. Avoid direct sunlight
Brand IP Statement(s)
FlexiJoint is a trademark of CATALO Group
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
FlexiJoint Formula by CATALO label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in FlexiJoint Formula by CATALO
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
BioCell Collagen
- › Hyaluronic Acid
- › Collagen Type II, Hydrolyzed
- › Chondroitin Sulfate, Depolymerized
FlexiJoint Cetylated Fatty Acids Complex
- › Cetylated Fatty Acids
Other (inactive) ingredients: Rice, Powder, Gelatin, Calcium Phosphate, Rice Hull Concentrate, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
FlexiJoint Formula by CATALO Drug Interactions
HelloPharmacist Interaction Report
FlexiJoint Formula by CATALO contains chondroitin sulfate, which has documented interactions with blood thinners.
The most serious concern is with warfarin (Coumadin): chondroitin may increase warfarin's blood-thinning effect, raising your bleeding risk. The product's other active ingredients—hyaluronic acid, hydrolyzed collagen type II, and several cetylated fatty acids—have either no documented interactions or data we couldn't check.
Read the full breakdown — every affected drug type, severity by severity
Additionally, if you take warfarin or another blood thinner, you'll want to confirm with your doctor or pharmacist before starting this supplement. Altogether, these interactions span 2 individual medications.
Several ingredients in this formula—cetyl myristoleate, cetyl myristate, cetyl palmitate, cetyl oleate, hydrolyzed collagen type II, and cetyl palmitoleate—we don't have interaction data for, so we can't rule out effects with other drugs. Use the medication checker on this page to look up your exact prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against FlexiJoint Formula?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in FlexiJoint Formula interact with 2 drugs. Click any drug to see the details.
1 of the 4 ingredients in FlexiJoint Formula interact with drugs. Each result below shows which ingredient is responsible. Chondroitin Sulfate, Depolymerized
WarfarinWarfarin
How Warfarin interacts with FlexiJoint Formula — through 1 ingredient. Tap an ingredient for the detail:
Chondroitin Sulfate, DepolymerizedWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate, Depolymerized + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with FlexiJoint Formula — through 1 ingredient. Tap an ingredient for the detail:
Chondroitin Sulfate, DepolymerizedWarfarin (coumadin) Moderate
Interaction Summary
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin.
Read the full Chondroitin Sulfate, Depolymerized + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in FlexiJoint Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chondroitin Sulfate, Depolymerized
Warfarin (Coumadin)
Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.
Brand information
Manufacturer and brand details for FlexiJoint Formula, from the product label.
FlexiJoint Formula by CATALO: Common Questions
Does FlexiJoint Formula by CATALO interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my arthritis?
Can I take this if I'm pregnant?
What are the common side effects?
I take a blood thinner. Is this safe for me?
What's hyaluronic acid in here for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if FlexiJoint Formula is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind FlexiJoint Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph → Herb & supplement monographChondroitin Sulfate
Interacts with 2 drugsChondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...
Read the full Chondroitin Sulfate monograph →Sources & How We Checked
FlexiJoint Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Chondroitin Sulfate 22 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
- Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
- Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
- Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
- Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
- Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
- Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
- Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
- Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
- Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
- Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
- von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
- Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
- Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
- Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
- Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
- Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC