Folic Acid 1,000 mcg Ingredients & Drug Interactions
by Nutricost
What is this page for?
First and foremost: checking Folic Acid 1,000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Folic Acid 1,000 mcg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Folic Acid 1,000 mcg by Nutricost
Ask about any prescription or over-the-counter medication and we check it for interactions with Folic Acid 1,000 mcg by Nutricost — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Folic Acid 1,000 mcg by Nutricost
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: folic acid at 1,000 micrograms (mcg) per capsule. Folic acid is a B vitamin that your body needs to make new cells and maintain normal cell function.
The capsule also contains rice flour and gelatin as inactive ingredients.
Does it work?
Strong evidence
Folic acid in this dose is effective for treating folate deficiency and likely effective for preventing birth defects called neural tube defects and for reducing toxicity from the cancer drug methotrexate. The evidence suggests it may help with depression, gum overgrowth caused by phenytoin, and cognitive impairment, though the data on these is less established.
How safe is it?
Well-documented data
At the 1,000 mcg dose in this product, folic acid is generally well tolerated in most adults. Doses below 1 mg daily rarely cause side effects; at higher doses (5 mg or more daily), some people report abdominal cramps, diarrhea, or rash.
Very large doses can interfere with vitamin B12 function and mask symptoms of certain anemias. Folic acid is recommended at standard prenatal doses during pregnancy to prevent birth defects and is considered safe while breastfeeding at normal recommended doses.
Population research has linked folic acid use late in pregnancy with a higher risk of childhood asthma; earlier use has not shown this association.
Meds to double-check
Moderate interaction found
Before taking this product, check with your own doctor or pharmacist if you take seizure medications (phenobarbital, phenytoin, or primidone), cancer treatments (methotrexate, capecitabine, or 5-fluorouracil), or the antiparasitic drug pyrimethamine. These are Moderate-severity interactions and need to be reviewed with your prescriber.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Nutricost Folic Acid 1,000 mcg is a straightforward supplement for folate deficiency and birth-defect prevention, and it's generally well tolerated. But if you take seizure medications, cancer drugs, or antiparasitic agents, you need to clear this with your own doctor or pharmacist first—the interactions are real and can affect how those medications work.
Talk it over before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Folic Acid 1,000 mcg, straight from the product label.
| Brand | Nutricost |
|---|---|
| Barcode (UPC) | 702669933193 |
| Net contents | 240 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 306219 |
| Product type | Vitamin |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Folic Acid 1,000 mcg by Nutricost, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Folic Acid | 1000 mcg | -- |
| Folate | 1700 mcg DFE | 430% |
Other ingredients: Rice Flour, Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional.
Formulation
Third party tested
Non-GMO Gluten-free
Made and quality tested in the USA with globally sourced ingredients.
Non-GMO Product
Precautions
Warning: For healthy individuals 18 years and older.
Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Do not use if safety seal is broken or missing.
Storage
Notice: Store in a cool, dry place.
Formula
Vitamin B9 1,000 mcg per serving
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Nutricost Quality Guaranteed Third Party Tested GMP Compliant Facility
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Folic Acid 1,000 mcg by Nutricost label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Folic Acid 1,000 mcg by Nutricost
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.
Folate
Other (inactive) ingredients: Rice Flour, Gelatin. These complete the product’s ingredient list but are not active constituents.
Folic Acid 1,000 mcg by Nutricost Drug Interactions
HelloPharmacist Interaction Report
Nutricost Folic Acid 1,000 mcg interacts with several important medication types, chiefly through its folic acid content.
The most serious concern is with seizure medications: folic acid can reverse the effects of phenobarbital and primidone, directly raising seizure risk, and may lower blood levels of phenytoin, also increasing seizure frequency—all Moderate severity. The product also poses Moderate risks with cancer and antiparasitic medications: it may reduce how well methotrexate works against cancer, increase toxicity from capecitabine and 5-fluorouracil, and counteract pyrimethamine's effects against certain parasitic infections.
Altogether, these interactions span 40 individual medications. If you take any seizure drug, cancer medication, or antiparasitic agent, check your exact medications with the tool on this page before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Folic Acid 1,000 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Folic Acid 1,000 mcg interact with 40 drugs. Click any drug to see the details.
1 of the 1 ingredient in Folic Acid 1,000 mcg interact with drugs. Each result below shows which ingredient is responsible. Folic Acid
Aprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Aprobarbital, Butabarbital, Phenobarbital interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Aspirin, Codeine Phosphate, Phenobarbital interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Atropine, Phenobarbital interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna Extract, Phenobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Belladonna, Phenobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Bellafoline, Phenobarbital interactionButabarbital, Phenobarbital, SecobarbitalS.B.P.
How Butabarbital, Phenobarbital, Secobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Butabarbital, Phenobarbital, Secobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Butalbital, Phenobarbital, Secobarbital interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCapecitabineXeloda
How Capecitabine interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidCapecitabine (xeloda) Moderate
Interaction Summary
Use of high-dose folic acid might contribute to capecitabine toxicity.
Read the full Folic Acid + Capecitabine interactionDehydrocholic Acid, Homatropine Methylbromide, PhenobarbitalG.B.S.
How Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionDicyclomine, PhenobarbitalBentyl w/ Pb
How Dicyclomine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Dicyclomine, Phenobarbital interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Ephedrine, Phenobarbital, Theophylline interactionErgotamine, Belladonna, PhenobarbitalBellamine, Bellaspas, Eperbel-S
How Ergotamine, Belladonna, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Ergotamine, Belladonna, Phenobarbital interactionFluorouracilEfudex, Tolak
How Fluorouracil interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic Acid5-fluorouracil Moderate
Interaction Summary
Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Read the full Folic Acid + Fluorouracil interactionFluorouracil (iv)Fluorouracil
How Fluorouracil (iv) interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic Acid5-fluorouracil Moderate
Interaction Summary
Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Read the full Folic Acid + Fluorouracil (iv) interactionFosphenytoinCerebyx
How Fosphenytoin interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenytoin (dilantin) Moderate
Interaction Summary
Folic acid might reduce serum levels of phenytoin in some patients.
Read the full Folic Acid + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenytoin (dilantin) Moderate
Interaction Summary
Folic acid might reduce serum levels of phenytoin in some patients.
Read the full Folic Acid + Fosphenytoin Sodium interactionHyoscyamine, PhenobarbitalLevsin Pb, Levsinex Pb Timecaps
How Hyoscyamine, Phenobarbital interacts with Folic Acid 1,000 mcg — through 1 ingredient. Tap an ingredient for the detail:
Folic AcidPhenobarbital (luminal) Moderate
Interaction Summary
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Read the full Folic Acid + Hyoscyamine, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Folic Acid 1,000 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Folic Acid
5-Fluorouracil
Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.
Capecitabine (Xeloda)
Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.
Methotrexate (Trexall, Others)
Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.
Phenobarbital (Luminal)
Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.
Phenytoin (Dilantin)
Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.
Primidone (Mysoline)
Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.
Pyrimethamine (Daraprim)
Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.
Brand information
Manufacturer and brand details for Folic Acid 1,000 mcg, from the product label.
Nutricost
See all Nutricost products- Name
- Nutricost
- Street Address
- 351 E 1750 N
- City
- Vineyard
- State
- UT
- ZipCode
- 84059
- Phone Number
- (866) 438-3694
- Web Address
- www.nutricost.com
Folic Acid 1,000 mcg by Nutricost: Common Questions
Does Folic Acid 1,000 mcg by Nutricost interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is 1,000 mcg of folic acid a safe dose?
Can I take folic acid while I'm pregnant?
Can I take folic acid while breastfeeding?
What is folic acid used for?
Can high-dose folic acid cause side effects?
Could folic acid interfere with my vitamin B12 levels?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Folic Acid 1,000 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Folic Acid 1,000 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Folic Acid 1,000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 56 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Folic Acid 56 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
- Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
- Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
- Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
- Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
- Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
- Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
- Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
- Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
- Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
- Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
- Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
- Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
- Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
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