Formula 22 Digest Chewables Ingredients & Drug Interactions
by NESS Nutritional Enzyme Support System
What is this page for?
First and foremost: checking Formula 22 Digest Chewables against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Formula 22 Digest Chewables is a dietary supplement by NESS Nutritional Enzyme Support System with 15 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Formula 22 Digest Chewables contains 14 active digestive enzymes designed to break down different types of food. Protease breaks down protein, lipase handles fat, lactase helps with milk sugar (lactose), and phytase works on plant compounds.
The rest — amylase, cellulase, peptidase, invertase, glucoamylase, alpha-galactosidase, pectinase, beta-glucanase, hemicellulase, and diastase — each target different starches, fibers, and carbohydrates to help your digestive system process food more completely. The product also contains inactive ingredients including dextrose, fructose, silica, raspberry flavor, plant cellulose, citric acid, beet powder for color, plant-derived flavor, and magnesium stearate.
Does it work?
Strong evidence
Lactase in this formula is effective for lactose intolerance — the main evidence-backed claim in this product. For the other enzymes and their potential roles in dyspepsia (indigestion), inflammatory bowel disease, or colic, the evidence isn't established in the data we hold.
Phytase's effectiveness for iron or zinc deficiency, aging skin, or growth also shows insufficient evidence. You're essentially getting a broad-spectrum enzyme blend, but most of its ingredients lack strong trial evidence to back their digestive benefits.
How safe is it?
Well-documented data
Protease, lipase, and phytase are generally well tolerated in adults, though digestive upset is possible and rare allergic reactions have occurred — especially in people handling powdered enzyme occupationally. Lactase is generally well tolerated when used as directed.
One worker developed a contact allergy to lactase powder, and phytase exposure in industrial settings has caused occupational asthma and lung inflammation (hypersensitivity pneumonitis) in some people. For pregnancy: lactase is likely safe, but protease should be avoided unless prescribed.
Lipase and phytase have insufficient data — talk with your doctor before regular use. For breastfeeding: lactase is likely safe, but protease, lipase, and phytase lack sufficient safety data — check with your doctor or pharmacist first before using regularly.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Before starting this product, run your exact medications through the search tool on this page, because we don't hold interaction data for several of the enzymes it contains.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This is a multi-enzyme digestive aid, with solid evidence behind lactase for lactose intolerance and less certainty about the others. If you have a serious digestive condition, check with your doctor first — especially if you're pregnant, breastfeeding, or have occupational exposure concerns.
Use it as directed and talk with your pharmacist or doctor if you have questions about whether it's right for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Formula 22 Digest Chewables, straight from the product label.
| Brand | NESS Nutritional Enzyme Support System |
|---|---|
| Barcode (UPC) | 707636034231 |
| Net contents | 180 Vegetarian Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 244147 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sugar | 1 Gram(s) | -- |
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Proprietary Enzyme Blend | 209 mg | -- |
Other ingredients: Dextrose, Fructose, Silica, natural Raspberry flavor, Cellulose, Plant, Citric Acid, Beet powder coloring, plant-derived Flavor, vegetarian Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Formulated exclusively for healthcare professionals NESS Digest Chewables are uniquely formulated to help optimize the digestion of all food groups, minimizing indigestion and malabsorption.
Non-GMO
Vegetarian
GMP compliant
Contains No: Aspartame, sucrose, salt, gluten, artificial colors or flavors, dairy products, wheat, soy, yeast or corn proteins.
Suggested/Recommended/Usage/Directions
Recommended Use: Chew one (1) tablet at the beginning of each meal, or as directed by your healthcare professional.
Precautions
Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your physician before use.
Use only if tamper evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
FDA Disclaimer Statement
These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure or prevent any disease.
FDA Statement of Identity
Enzyme Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Other (inactive) ingredients: Dextrose, Fructose, Silica, Natural Raspberry flavor, Cellulose, Plant, Citric Acid, Beet powder coloring, Plant-derived Flavor, Vegetarian Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Formula 22 Digest Chewables. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Formula 22 Digest Chewables, from the product label.
NESS Nutritional Enzyme Support System
See all NESS Nutritional Enzyme Support System products- Name
- Enzymes Inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 1-800-637-7893
- Web Address
- www.nessenzymes.com
Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System: Common Questions
Does Formula 22 Digest Chewables by NESS Nutritional Enzyme Support System interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does lactase in this formula actually work for lactose intolerance?
Is it safe to use while pregnant?
Can I use this while breastfeeding?
What are the side effects?
Does it help with gas or bloating?
Do I need to worry about other ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Formula 22 Digest Chewables is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Formula 22 Digest Chewables’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Formula 22 Digest Chewables's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC