Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Fortify Optima Age 50+ Probiotic 90 Billion Ingredients & Drug Interactions

by Nature's Way

Fortify Optima Age 50+ Probiotic 90 Billion label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fortify Optima Age 50+ Probiotic 90 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fortify Optima Age 50+ Probiotic 90 Billion is a dietary supplement by Nature's Way with 5 active ingredients. Its ingredients are commonly taken for constipation and digestive health, source of prebiotic fiber (inulin), coffee substitute.Based on those ingredients, 2,108 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gum Acacia Fiber, Chicory root Fiber, organic Blue Agave Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 18 active ingredients.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Proprietary Plant-Based Prebiotic Blend” is a proprietary blend — the label gives one combined amount (75 mg) without saying how much of each component you get.
  • “Lactobacilli/Streptococcus Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 18 ingredients, including multiple live probiotic strains—Lactobacillus acidophilus (two forms), Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus paracasei, Bifidobacterium species (six strains), and Streptococcus thermophilus—along with prebiotic fibers like inulin, chicory root fiber, and gum acacia fiber. The probiotics are meant to support digestive health; the prebiotics feed the beneficial bacteria so they can thrive.

The inactive ingredients are potato maltodextrin, gellan gum, hypromellose, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health for adults 50+.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Dyspepsia, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.

Evidence for this product's effectiveness is mixed and varies by ingredient. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis.

Inulin is possibly effective for obesity, constipation, and diabetes. Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections.

However, many of the product's conditions—such as allergic rhinitis, cognitive decline, and anxiety—lack sufficient reliable evidence to rate. Streptococcus thermophilus has insufficient evidence for any of the conditions we have data on.

The evidence, ingredient by ingredient Chicory Gum Arabic Inulin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these probiotics are generally well tolerated in healthy adults, though people with weakened immune systems should be cautious—rare cases of serious bacterial infection (bacteremia or sepsis) have been reported in critically ill or immunocompromised patients. Gastrointestinal side effects like bloating, flatulence, and mild diarrhea are the most common adverse effects, especially with the probiotic and prebiotic fibers; these often subside within a couple of weeks.

Chicory root fiber may trigger allergies in people sensitive to ragweed and related plants, and occupational exposure has caused asthma, rhinitis, and skin reactions. Check with your doctor before starting this product, particularly if you have a compromised immune system or are very ill.

Side effects, ingredient by ingredient Chicory Gum Arabic Inulin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Chicory, Gum Arabic, Lactobacillus Acidophilus, Inulin, Bifidobacterium Breve, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 2,109 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate their dose from this product by several hours—the live organisms here can be killed off, making the probiotics less effective. If you take diabetes medications or antidiabetes drugs, check with your doctor before starting, since chicory root fiber and inulin may theoretically increase your risk of low blood sugar.

If you take amoxicillin, separate it from this product by at least 2 hours to protect the antibiotic's absorption. For any other oral medications, allow a gap as well, since gum acacia fiber can affect how your body absorbs them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic-and-prebiotic blend may be worth considering if you're over 50 and dealing with IBS, antibiotic-related diarrhea, or digestive wellness—but if you take antibiotics, diabetes medications, or amoxicillin, you'll need to clear it with your doctor or pharmacist first, since several ingredients can interfere with how those drugs work. People with weakened immune systems should also check with their healthcare provider before starting.

Most healthy adults tolerate it well, though gas and bloating are common at first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fortify Optima Age 50+ Probiotic 90 Billion, straight from the product label.

Brand Nature's Way
Net contents 30 Delayed-Release Capsules
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 273451
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Seniors/Mature (>50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus acidophilus La-140 NP--
Lactobacillus plantarum Lp-1150 NP--
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium lactis Bi-070 NP--
Bifidobacterium infantis Bi-260 NP--
Bifidobacterium lactis Bl-040 NP--
Bifidobacterium bifidum Bb-060 NP--
Chicory root Fiber0 NP--
Bifidobacterium breve Bb-030 NP--
Streptococcus thermophilus St-210 NP--
Gum Acacia Fiber0 NP--
Bifidobacteria Blend0 NP--
organic Blue Agave Inulin0 NP--
Lactobacillus paracasei Lpc-370 NP--
HOWARU Lactobacillus rhamnosus HN0010 NP--
HOWARU Lactobacillus acidophilus NCFM0 NP--
HOWARU Bifidobacterium lactis HN0190 NP--
Proprietary Plant-Based Prebiotic Blend75 mg--
Bifidobacterium lactis Bb-120 NP--
Lactobacilli/Streptococcus Blend0 NP--
Bifidobacterium bifidum/lactis Bb-020 NP--
Fortify Optima Age 50+ 90 Billion CFU Proprietary Probiotic Blend550 mg--

Other ingredients: Potato Maltodextrin, Gellan Gum, Hypromellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Powerful probiotics for daily digestive & immune health for adults age 50+ Formulated with 15 probiotic strains + prebiotics 90 billion active cultures, guaranteed!

Age 50+ Probiotic + Prebiotics

90 Billion live probiotic cultures per capsule 15 probiotic strains

Formulation

One capsule, multiple benefits Targeted delivery

Gluten free. No artificial colors. Certified Gluten Free gfco.org Non GMO Project Verified nongmoproject.org

Advanced care

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Keep refrigerated to maintain maximum potency.

Keep refrigerated to maintain maximum potency.

Brand IP Statement(s)

Howaru probiotic quality you can feel HOWARU is a registered trademark of International Flavors & Fragrances Inc. or its affiliates. HN001 and HN019 are trademarks of the Fonterra Group of companies used under license. The probiotic strains contained in this product are manufactured by IFF.

Copyright 2021 Nature's Way Brands, LLC

Seals/Symbols

Certified Gluten Free gfco.org Non GMO Project Verified nongmoproject.org

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 capsule daily. May be taken at any time, with or without food.

General Statements

Questions? 1-800-9NATURE / fortifyprobiotics.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fortify Optima Age 50+ Probiotic 90 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Plant-Based Prebiotic Blend

75 mg per serving

Fortify Optima Age 50+ 90 Billion CFU Proprietary Probiotic Blend

550 mg per serving
  • › Bifidobacteria Blend
  • › Lactobacilli/Streptococcus Blend

Other (inactive) ingredients: Potato Maltodextrin, Gellan Gum, Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way Drug Interactions

Want to check YOUR meds against Fortify Optima Age 50+ Probiotic 90 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,108Drugs
2,108 Moderate

Ingredients driving the most interactions

Gum Acacia Fiber 2,022
Chicory root Fiber 86
organic Blue Agave Inulin 86

Individual Drug Interactions

The ingredients in Fortify Optima Age 50+ Probiotic 90 Billion interact with 2,108 drugs. Click any drug to see the details.

3 of the 5 ingredients in Fortify Optima Age 50+ Probiotic 90 Billion interact with drugs. Each result below shows which ingredient is responsible. Gum Acacia Fiber Chicory root Fiber organic Blue Agave Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in Fortify Optima Age 50+ Probiotic 90 Billion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gum Acacia Fiber2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Gum Acacia Fiber full monograph & interactions

Chicory root Fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory root Fiber full monograph & interactions

organic Blue Agave Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
organic Blue Agave Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fortify Optima Age 50+ Probiotic 90 Billion, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
fortifyprobiotics.com
Pharmacist Counseling Corner

Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way: Common Questions

Does Fortify Optima Age 50+ Probiotic 90 Billion by Nature's Way interact with any medications?
Yes. Based on its ingredients, Fortify Optima Age 50+ Probiotic 90 Billion has a known interaction with 2,108 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fortify Optima Age 50+ Probiotic 90 Billion contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work while I'm on antibiotics?
Not effectively. Antibiotics kill the live organisms in probiotics, which reduces how well they work. Your doctor or pharmacist can tell you how to space doses of each to minimize that problem.
What's inulin doing in a probiotic supplement?
Inulin is a prebiotic—it feeds the beneficial bacteria in the product so they can grow and do their job better in your gut. It's also possibly effective for constipation and may help with blood sugar control in people with diabetes.
Can I take this if I have a sensitive stomach?
These probiotics are generally well tolerated, but bloating, gas, and mild diarrhea are common, especially at first—they often settle down after a couple of weeks. If your stomach is already upset, starting with a smaller dose or taking it with food may help; talk to your pharmacist.
Is this safe during pregnancy?
Most of the probiotic strains in here are rated possibly safe in pregnancy, but chicory root fiber is rated possibly unsafe because of historical concerns it might stimulate the uterus. Talk with your doctor or midwife before taking this product if you're pregnant.
What if I have a weak immune system?
People with weakened or compromised immune systems should check with their doctor first. While serious infection from probiotics is rare, a few cases of bacteremia have been reported in critically ill or immunocompromised patients—your provider can help you decide if it's right for you.
Does this product have fillers?
Yes—it contains potato maltodextrin, gellan gum, hypromellose, magnesium stearate, and silica as inactive ingredients to hold the capsule together and keep the product stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fortify Optima Age 50+ Probiotic 90 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fortify Optima Age 50+ Probiotic 90 Billion label
Go deeper

The Full Monographs Behind Fortify Optima Age 50+ Probiotic 90 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph → Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Fortify Optima Age 50+ Probiotic 90 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Chicory 13 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5. PubMed
  3. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  4. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  5. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  6. Cadot, P., Kochuyt, A. M., van Ree, R., and Ceuppens, J. L. Oral allergy syndrome to chicory associated with birch pollen allergy. Int.Arch.Allergy Immunol. 2003;131(1):19-24. PubMed
  7. Friis, B., Hjorth, N., Vail, J. T., Jr., and Mitchell, J. C. Occupational contact dermatitis from Cichorium (chicory, endive) and Lactuca (lettuce). Contact Dermatitis 1975;1(5):311-313.
  8. Nemery, B. and Demedts, M. Occupational asthma in a chicory grower. Lancet 3-25-1989;1(8639):672-673. PubMed
  9. Pirson F, Detry B, Pilette C. Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with bet v 1-related protein. J Investig Allergol Clin Immunol 2009;19(4):306-10.
  10. Willi R, Pfab F, Huss-Marp J, et al. Contact anaphylaxis and protein contact dermatitis in a cook handling chicory leaves. Contact Dermatitis 2009;60(4):226-7. PubMed
  11. Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
  12. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  13. Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9. PubMed

See these in context on the Chicory monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
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See these in context on the Bifidobacterium Breve monograph →

Streptococcus Thermophilus 21 references
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  16. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
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See these in context on the Streptococcus Thermophilus monograph →

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
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See these in context on the Gum Arabic monograph →

Inulin 17 references
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  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
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  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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