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Dietary supplement

Full Spectrum Wild Lettuce 450 mg Ingredients & Drug Interactions

by Swanson Premium Brand

Full Spectrum Wild Lettuce 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Full Spectrum Wild Lettuce 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Full Spectrum Wild Lettuce 450 mg is a dietary supplement by Swanson Premium Brand with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild lettuce at 450 mg per capsule. The capsule itself is made from gelatin and filled with microcrystalline cellulose, silica, and rice extract blend as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for wild lettuce in our data, so we can't tell you whether it works for any particular purpose based on the evidence we have on file.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce comes with limited safety data in humans, and high doses have been tied to side effects. Large amounts — or prematurely harvested wild lettuce — can cause sweating, fast breathing, rapid heartbeat, dizziness, ringing in the ears, vision changes, pressure in the head, sleepiness, agitation, slowed breathing, and in severe cases, coma or death.

Topically, it may cause skin irritation (contact dermatitis). Due to insufficient safety information, wild lettuce is best avoided during pregnancy and while breastfeeding.

If you're pregnant, nursing, or planning either, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before adding this product if you take central nervous system depressants (sedatives, sleep aids, or sedating pain relievers) or anticholinergic medications (drugs for overactive bladder, certain nerve pain, or related conditions). The interaction checker on this page can help you look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild lettuce is generally not well characterized in human safety studies, and the dose in this product (450 mg) is a moderate amount. It can interact with sedating drugs and potentially with anticholinergic medications.

If you take any prescription medications — especially sleep aids, sedatives, pain relievers, or drugs for bladder or nerve conditions — check them against this product with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Full Spectrum Wild Lettuce 450 mg, straight from the product label.

Brand Swanson Premium Brand
Barcode (UPC) 087614115054
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 203142
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
087614115054
IngredientAmount% DV
Wild Lettuce450 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Silica, Rice extract Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bringing wellness to the world since 1969

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Warning: Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are taking prescription medications, especially CNS depressants or sedatives, or if you have a medical condition, especially glaucoma or benign prostatic hyperplasia.

Consult your healthcare provider before use if you are taking prescription medications, especially CNS depressants or sedatives, or if you have a medical condition, especially glaucoma or benign prostatic hyperplasia.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one capsule one to two times per day with food.

General

SW1505 Rev 2 02 27 18

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Full Spectrum Wild Lettuce 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Wild Lettuce

Interacts with
393 drugs
450 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silica, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand Drug Interactions

Want to check YOUR meds against Full Spectrum Wild Lettuce 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce 393

Individual Drug Interactions

The ingredients in Full Spectrum Wild Lettuce 450 mg interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Full Spectrum Wild Lettuce 450 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce

Each ingredient & the kinds of drugs it affects

For each ingredient in Full Spectrum Wild Lettuce 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Full Spectrum Wild Lettuce 450 mg, from the product label.

Swanson Premium Brand

See all Swanson Premium Brand products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand: Common Questions

Does Full Spectrum Wild Lettuce 450 mg by Swanson Premium Brand interact with any medications?
Yes. Based on its ingredients, Full Spectrum Wild Lettuce 450 mg has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Full Spectrum Wild Lettuce 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data for wild lettuce during pregnancy and breastfeeding isn't reliable enough to recommend it. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, nursing, or planning to become pregnant.
What side effects might I experience from wild lettuce?
At this dose, side effects aren't well documented. However, large amounts of wild lettuce have been reported to cause dizziness, pressure in the head, sleepiness, agitation, fast heartbeat, and sweating. If you take more than directed or use prematurely harvested wild lettuce, the risk goes up significantly.
Is this product safe if I take sleeping pills or sedatives?
Wild lettuce can amplify the drowsiness and depressant effects of sedating drugs. Before combining this supplement with any sleep aid, sedative, or pain reliever that makes you drowsy, check with your doctor or pharmacist.
What is wild lettuce used for?
Our data on file doesn't establish an effectiveness rating for wild lettuce for any condition, so we can't tell you what it's intended to treat based on the evidence we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Full Spectrum Wild Lettuce 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Full Spectrum Wild Lettuce 450 mg label
Go deeper

The Full Monographs Behind Full Spectrum Wild Lettuce 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Full Spectrum Wild Lettuce 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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