Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

G.I. Detox Ingredients & Drug Interactions

by Bio-Botanical Research

G.I. Detox label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking G.I. Detox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

G.I. Detox is a dietary supplement by Bio-Botanical Research with 2 active ingredients. Its ingredients are commonly taken for poisoning and drug overdose (in emergency care), gas and bloating, upset stomach.Based on those ingredients, 2,027 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Activated Charcoal. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against G.I. Detox by Bio-Botanical Research

Ask about any prescription or over-the-counter medication and we check it for interactions with G.I. Detox by Bio-Botanical Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of G.I. Detox by Bio-Botanical Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

G.I. Detox contains 2 active ingredients.

Activated charcoal is a porous form of carbon that binds to substances in your digestive tract. Pyrophyllite clay is included as a second active component, though we hold no interaction data for it.

The product also contains cellulose and water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Activated Charcoal's overall clinical evidence instead.

Moderate

Some clinical evidence supports Activated Charcoal for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Poisoning — rated "Possibly Effective" (Natural Medicines).

For activated charcoal specifically, the evidence supports its use in poisoning—it's rated possibly effective for that purpose. For the other uses listed on many activated charcoal products—including high cholesterol, indigestion, hangovers, wound healing, and kidney disease—the evidence we have is insufficient to say whether it works.

Pyrophyllite clay has no effectiveness rating in our data.

The evidence, ingredient by ingredient Activated Charcoal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Activated charcoal is generally well tolerated for short-term use, but constipation is common and can be ongoing. Black stools, belly pain, bloating, and gas are also reported.

Rarely, it may cause a blockage in your intestines. Because activated charcoal reduces how your body absorbs many substances, it can interfere with nutrient and medication absorption.

The safety data for routine use in pregnancy is limited; use only under medical guidance if you're pregnant or nursing. We have no safety information on file for pyrophyllite clay.

Side effects, ingredient by ingredient Activated Charcoal

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Activated Charcoal.
  • The most serious interaction on file is rated Major.
  • For scale: 2,028 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any oral medications—activated charcoal can reduce how much of them your body absorbs. If you use oral contraceptives, be aware that charcoal may lower their effectiveness.

Also, avoid taking this at the same time you drink alcohol, as alcohol reduces charcoal's binding ability.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

G.I. Detox is primarily useful if you've taken a poison and your healthcare provider recommends activated charcoal.

If you take any regular medications—especially heart drugs, blood thinners, or birth control—you'll need to check with your doctor or pharmacist first, because activated charcoal can interfere with how they work. Constipation is likely, and the long-term safety profile isn't well established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about G.I. Detox, straight from the product label.

Brand Bio-Botanical Research
Barcode (UPC) 898870002138
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2013
DSLD ID 20734
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for G.I. Detox by Bio-Botanical Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
898870002138
IngredientAmount% DV
Activated Charcoal188 mg--
Pyrophyllite Clay562 mg--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use 1-2 capsules with a full glass of water between meals or as directed. Take 1 hour apart from other supplements or medications.

Precautions

Not recommended for use during pregnancy.

Take 1 hour apart from other supplements or medications.

Discontinue use should adverse reactions occur.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. (FDA) These products are not intended to diagnose, treat, cure or prevent any disease.

General Statements

Gentle and Effective Cleanse*

FDA Statement of Identity

Dietary Supplement

Formulation

Contains no allergens such as dairy, wheat, gluten, sugar, soy, preservatives, animal products, artificial flavorings or colorings.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

G.I. Detox by Bio-Botanical Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

G.I. Detox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in G.I. Detox by Bio-Botanical Research

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Activated Charcoal

Interacts with
2,027 drugs
188 mg per serving

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings...

Activated Charcoal monograph & interactions

Pyrophyllite Clay

562 mg per serving

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

G.I. Detox by Bio-Botanical Research Drug Interactions

Want to check YOUR meds against G.I. Detox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,027Drugs
2,022 Major 5 Moderate

Ingredients driving the most interactions

Activated Charcoal 2,027

Individual Drug Interactions

The ingredients in G.I. Detox interact with 2,027 drugs. Click any drug to see the details.

1 of the 2 ingredients in G.I. Detox interact with drugs. Each result below shows which ingredient is responsible. Activated Charcoal

Each ingredient & the kinds of drugs it affects

For each ingredient in G.I. Detox with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Activated Charcoal3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Activated Charcoal full monograph & interactions
The maker

Brand information

Manufacturer and brand details for G.I. Detox, from the product label.

Bio-Botanical Research

See all Bio-Botanical Research products
Name
BIO-BOTANICAL RESEARCH INC.
Street Address
P.O. BOX 2499
City
Aptos
State
CA
ZipCode
95001
Web Address
biobotanicalresearch.com
Pharmacist Counseling Corner

G.I. Detox by Bio-Botanical Research: Common Questions

Does G.I. Detox by Bio-Botanical Research interact with any medications?
Yes. Based on its ingredients, G.I. Detox has a known interaction with 2,027 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
G.I. Detox contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my other medications?
Activated charcoal can bind to many drugs in your stomach and reduce how much of them you absorb, potentially making them less effective. The span of affected medications is broad. Talk with your doctor or pharmacist about your specific medications before you start G.I. Detox.
What's the most common side effect?
Constipation is the most frequent complaint, though it's usually temporary. Black stools, belly pain, bloating, and gas are also common. Rarely, it may cause a blockage in your digestive tract.
Can I use this if I'm pregnant or breastfeeding?
The safety data for activated charcoal in pregnancy and lactation isn't well studied. The rating is possibly safe, but use only under medical guidance if you're pregnant or nursing. Talk with your doctor or pharmacist for personalized advice.
What does activated charcoal actually do?
Activated charcoal is a porous form of carbon that binds to substances in your digestive tract. It's rated possibly effective for poisoning, but evidence for other uses like high cholesterol or hangovers is insufficient.
Should I take this every day?
Activated charcoal is generally low-risk for short-term use, but safety for routine daily use isn't well established. Because it reduces absorption of many substances, long-term use could affect your nutrition and how other things work. Talk with your doctor about whether regular use is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if G.I. Detox is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

G.I. Detox label
Go deeper

The Full Monographs Behind G.I. Detox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph →
Sources

Sources & How We Checked

G.I. Detox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Activated Charcoal 14 references
  1. Kaaja RJ, Kontula KK, Raiha A, Laatikainen T. Treatment of cholestasis of pregnancy with peroral activated charcoal. A preliminary study. Scand J Gastroenterol 1994;29:178-81.
  2. Anon. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin T
  3. Park GD, Spector R, Kitt TM. Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial. J Clin Pharmacol 1988;28:416-9. PubMed
  4. Hoegberg LC, Angelo HR, Christophersen AB, Christensen HR. Effect of ethanol and pH on the adsorption of acetaminophen (paracetamol) to high surface activated charcoal, in vitro studies. J Toxicol Clin Toxicol 2002;40:59-67. PubMed
  5. Brahmi N, Kouraichi N, Thabet H, Amamou M. Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. Am J Emerg Med 2006;24(4):440-3. PubMed
  6. Gude AB, Hoegberg LC, Angelo HR, Christensen HR. Dose-dependent adsorptive capacity of activated charcoal for gastrointestinal decontamination of a simulated paracetamol overdose in human volunteers. Basic Clin Pharmacol Toxicol 2010;106(5)406-10. PubMed
  7. Wananukul W, Klaikleun S, Sriapha C, Tongpoo A. Effect of activated charcoal in reducing paracetamol absorption at supra-therapeutic dose. J Med Assoc Thai 2010;93(10):1145-9.
  8. Wang Z, Cui M, Tang L, et al. Oral activated charcoal suppresses hyperphosphataemia in haemodialysis patients. Nephrology (Carlton) 2012;17(7):616-20. PubMed
  9. Wang X, Mondal S, Wang J, et al. Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects. Am J Cardiovasc Drugs 2014;14(2):147-54. PubMed
  10. Chyka PA, Seger D, Krenzelok EP, et al. Position paper: single-dose activated charcoal. Clin Toxicol (Phila) 2005;43(2):61-87. PubMed
  11. Chiew AL, Gluud C, Brok J, Buckley NA. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev 2018;2:CD003328. PubMed
  12. Elomaa K, Ranta S, Tuominen J, Lähteenmäki P. Charcoal treatment and risk of escape ovulation in oral contraceptive users. Hum Reprod. 2001;16(1):76-81. PubMed
  13. Gao Y, Wang G, Li Y, Lv C, Wang Z. Effects of oral activated charcoal on hyperphosphatemia and vascular calcification in Chinese patients with stage 3-4 chronic kidney disease. J Nephrol. 2019;32(2):265-72. PubMed
  14. Skov K, Graudal NA, Jürgens G. The effect of activated charcoal on drug exposure following intravenous administration: A meta-analysis. Basic Clin Pharmacol Toxicol 2021;128(4):568-578. PubMed

See these in context on the Activated Charcoal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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