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Dietary supplement

GABA Ingredients & Drug Interactions

by Ultimate Nutrition Platinum Series

GABA label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GABA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GABA is a dietary supplement by Ultimate Nutrition Platinum Series with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma Amino Butyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GABA by Ultimate Nutrition Platinum Series

Ask about any prescription or over-the-counter medication and we check it for interactions with GABA by Ultimate Nutrition Platinum Series — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GABA by Ultimate Nutrition Platinum Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gamma-aminobutyric acid, commonly called GABA. GABA is a natural chemical messenger in the brain that plays a role in relaxation and sleep.

The capsule also includes inactive ingredients (cellulose, dicalcium phosphate, gelatin, and magnesium stearate) that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: muscle tone and human growth hormone stimulation.
  • We looked for evidence on: muscle strength, athletic performance, growth factor support.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

The evidence for GABA isn't established in the data we hold. The product has been studied for anxiety, ADHD, athletic performance, cerebral palsy, and chronic bronchitis, but all those uses are rated as having insufficient reliable evidence to judge whether it actually works.

That doesn't mean it doesn't work — it means the research so far isn't strong enough to say one way or the other.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, GABA is generally well tolerated short-term, though long-term safety hasn't been well studied. Common side effects in trials included drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea.

One patient also reported a temporary stopping of menstrual periods. The safety data available isn't thorough enough to be certain, so you shouldn't take it unless your doctor advises you to.

There isn't enough safety information for breastfeeding — the data advises against it unless your doctor says otherwise. Pregnancy safety data is not on file for this ingredient.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start GABA, double-check your medications against these categories: blood pressure drugs (antihypertensives) — the Moderate concern — and sedating drugs (CNS depressants) such as sleep aids, benzodiazepines, and opioids, which carry a Minor risk. Talk with your doctor or pharmacist to confirm your specific medications are okay to combine with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GABA may appeal to someone interested in relaxation or sleep support, but the evidence that it works for those purposes hasn't been established. If you take blood pressure medications or sedating drugs, check with your doctor or pharmacist before starting GABA — it could theoretically increase their effects.

Long-term safety isn't well studied, and breastfeeding isn't recommended without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA, straight from the product label.

Brand Ultimate Nutrition Platinum Series
Barcode (UPC) 099071004161
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 293458
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA by Ultimate Nutrition Platinum Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
099071004161
IngredientAmount% DV
Gamma Amino Butyric Acid1500 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two capsules daily, preferably at bedtime, or as recommended by a health care professional.

Formula

GABA is a non-protein amino acid that is essential for muscle tone and has been shown to stimulate the production of Human Growth Hormones.

Precautions

Do not use if seal is broken or missing

Keep out of reach of children

Storage

Protect from heat, light, and moisture Store in a cool, dry place; 15-30 degrees C (59-86 degrees F)

FDA Disclaimer Statement

These statements have not been evaluated by the Food an Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Daily Pre During Post Night

Formulation

Beneficial for overall well-being

FDA Statement of Identity

Gamma Amino Butyric Acid Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GABA by Ultimate Nutrition Platinum Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GABA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GABA by Ultimate Nutrition Platinum Series

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Gamma Amino Butyric Acid

Interacts with
419 drugs
1500 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma Amino Butyric Acid monograph & interactions

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

GABA by Ultimate Nutrition Platinum Series Drug Interactions

Want to check YOUR meds against GABA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma Amino Butyric Acid 419

Individual Drug Interactions

The ingredients in GABA interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in GABA interact with drugs. Each result below shows which ingredient is responsible. Gamma Amino Butyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma Amino Butyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma Amino Butyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GABA, from the product label.

Ultimate Nutrition Platinum Series

See all Ultimate Nutrition Platinum Series products
Name
Ultimate Nutrition, Inc.
Street Address
P.O. Box 643
City
Farmington
State
CT
ZipCode
06034
Web Address
www.UltimateNutrition.com
Pharmacist Counseling Corner

GABA by Ultimate Nutrition Platinum Series: Common Questions

Does GABA by Ultimate Nutrition Platinum Series interact with any medications?
Yes. Based on its ingredients, GABA has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is GABA and what does it do in the body?
GABA (gamma-aminobutyric acid) is a natural brain chemical that helps with relaxation and sleep. This supplement is the same compound your body makes on its own — the capsule just adds more of it.
Will GABA help with anxiety or sleep?
GABA has been studied for both anxiety and sleep issues, but the research so far isn't strong enough to say whether it actually works. The evidence is listed as insufficient reliable evidence, so we can't tell you one way or the other.
What are the side effects?
The most common ones in studies were drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea. One person also reported temporary menstrual changes. A complete safety picture hasn't been established, which is why long-term use isn't well understood.
Can I take GABA while breastfeeding?
The safety data advises against GABA while breastfeeding unless your doctor advises otherwise. There isn't enough information to know whether it's safe, so talk with your doctor or pharmacist for personalized guidance.
Is there anything else in this capsule besides GABA?
Yes — the capsule contains inactive ingredients (cellulose, dicalcium phosphate, gelatin, and magnesium stearate) that act as fillers and binders. These help hold the supplement together and are common in most capsule products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA label
Go deeper

The Full Monographs Behind GABA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

GABA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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