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Dietary supplement

Chill Ingredients & Drug Interactions

by Purium

Chill label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chill against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chill is a dietary supplement by Purium with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Suntheanine, GABA. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chill by Purium

Ask about any prescription or over-the-counter medication and we check it for interactions with Chill by Purium — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chill by Purium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

Chill contains two active ingredients. GABA (gamma-aminobutyric acid) is a brain chemical your body makes naturally; the supplement form is meant to support relaxation.

Suntheanine is a form of theanine, an amino acid found in tea that's thought to promote calm without drowsiness. The product also contains inactive ingredients (purified water, erythritol, glycerine, citric acid, Mirenat-GA, stevia leaf extract, and natural watermelon flavor) that serve as the liquid base and flavoring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: relaxation and stress relief.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, Post-traumatic stress disorder (PTSD), sleep quality — and 1 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Post-traumatic stress disorder (PTSD).
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

The evidence for GABA's effectiveness is insufficient—we don't have solid research showing it works for the conditions it's marketed for, including anxiety, ADHD, athletic performance, and cerebral palsy. Theanine (Suntheanine) is rated possibly effective for cognitive function, though the evidence for other uses like anxiety disorder or Alzheimer's disease is insufficient.

Neither ingredient has strong proof backing its use in this product.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba) Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

GABA is generally well tolerated in the short term, but long-term safety hasn't been well studied. The most common side effects are drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea.

One case reported a temporary loss of menstrual periods. Theanine may cause headaches, drowsiness, or increased dream activity.

Like GABA, its long-term safety is unclear. For pregnancy: there isn't enough safety data for either ingredient, so both should be avoided in pregnancy unless your doctor advises otherwise.

For breastfeeding: the safety data advises against GABA, and there isn't enough information on theanine, so it's best to avoid it while nursing. Talk with your doctor or pharmacist about your personal situation.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba) Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it with your doctor or pharmacist if you're on blood pressure medications (antihypertensives)—Chill could lower your pressure too much. Also flag it if you take central nervous system depressants like sedatives, sleep aids, or opioids, or if you're on serotonergic antidepressants.

These are the medication types with the most concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Chill might appeal to someone looking for a calming supplement, but the evidence that it works is weak. If you take blood pressure medications or CNS depressants (sedatives, sleep aids, opioids), you'll want to check with your doctor or pharmacist first—this product could amplify their effects.

Pregnant or breastfeeding? Avoid it unless your healthcare provider says it's okay.

Run your medications through the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chill, straight from the product label.

Brand Purium
Net contents 30 mL
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183310
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chill by Purium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.9 Gram(s)
Maximum serving Sizes:
0.9 Gram(s)
Servings per container
33
IngredientAmount% DV
GABA0 NP--
Proprietary Blend200 mg--
Suntheanine0 NP--

Other ingredients: purified Water, Erythritol, Glycerine, Citric Acid, Mirenat-GA, Stevia leaf extract, natural Watermelon flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Gluten-free

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before use. As a dietary supplement, spray six (6) times under the tongue, hold for 20 seconds and swallow.

Storage

Store in a cool, dry place.

Precautions

Caution: Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Mirenat-GA is a registered trademark of VEDEQSA, Inc.

General

RD0817 #3720

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chill by Purium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chill label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chill by Purium

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.9 Gram(s) Dosage formLiquid Servings per container33 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

200 mg per serving

Other (inactive) ingredients: Purified Water, Erythritol, Glycerine, Citric Acid, Mirenat-GA, Stevia leaf extract, Natural Watermelon flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chill by Purium Drug Interactions

Want to check YOUR meds against Chill?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
172 Moderate 393 Minor

Ingredients driving the most interactions

Suntheanine 565
GABA 419

Individual Drug Interactions

The ingredients in Chill interact with 565 drugs. Click any drug to see the details.

2 of the 2 ingredients in Chill interact with drugs. Each result below shows which ingredient is responsible. Suntheanine GABA

Each ingredient & the kinds of drugs it affects

For each ingredient in Chill with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chill, from the product label.

Purium

See all Purium products
Name
Purium
Street Address
2610 Homestead Pl.
City
Rancho Dominguez
State
CA
ZipCode
90220
Phone Number
1-888-747-6733
Web Address
puriumcorp.com
Pharmacist Counseling Corner

Chill by Purium: Common Questions

Does Chill by Purium interact with any medications?
Yes. Based on its ingredients, Chill has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chill contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does GABA in this product actually work?
The evidence isn't strong enough to say. Research so far shows insufficient reliable evidence that GABA supplements help with anxiety, ADHD, athletic performance, or the other uses this product may claim. We don't know yet if taking GABA by mouth does what it's supposed to do.
What about the theanine—is that proven?
Theanine is possibly effective for cognitive function, which is the strongest evidence we have. For anxiety, Alzheimer's disease, and other conditions it might be marketed for, the evidence is insufficient. So it's a mixed picture.
Can I take this while I'm pregnant or nursing?
No. There isn't enough safety data for either GABA or theanine in pregnancy or while breastfeeding. Your doctor or pharmacist can talk with you about whether it might be okay in your specific case, but the data advises against it.
What side effects should I watch for?
The most common are drowsiness, stomach upset, nausea, and muscle weakness from GABA, plus headaches and increased dream activity from theanine. A thorough safety evaluation hasn't been done, so other effects might occur.
Is this safe to use long-term?
We don't have good data on long-term safety for either ingredient, so we can't say. If you're thinking of using it regularly, talk with your doctor or pharmacist first.
Does this product have fillers or other junk in it?
It has inactive ingredients like water, erythritol (a sweetener), glycerine, citric acid, stevia extract, and watermelon flavoring. These are the liquid base and flavor—pretty standard for a liquid supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chill label
Go deeper

The Full Monographs Behind Chill’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

Chill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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