Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Gas Defense Formula Ingredients & Drug Interactions

by Schiff Digestive Advantage

Gas Defense Formula label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gas Defense Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gas Defense Formula is a dietary supplement by Schiff Digestive Advantage with 6 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBI-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gas Defense Formula by Schiff Digestive Advantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Gas Defense Formula by Schiff Digestive Advantage — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gas Defense Formula by Schiff Digestive Advantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.

Gas Defense Formula contains 6 active ingredients, most of them digestive enzymes. Invertase, cellulase, hemicellulase, and alpha-galactosidase break down different carbohydrates and fiber in your food to help reduce gas and bloating.

The formula also includes BC30 Bacillus coagulans, a probiotic (live beneficial bacteria) added to support digestion and gut balance. The remaining ingredients are inactive — fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: helps stop intestinal gas before it starts.
  • We looked for evidence on: Flatulence, Irritable bowel syndrome (IBS), bloating, digestive discomfort.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Flatulence.

The BC30 Bacillus coagulans ingredient in this product has possibly effective evidence for constipation and irritable bowel syndrome (IBS). For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence isn't strong enough to rate whether it works.

We don't have effectiveness data on file for the digestive enzymes in the formula.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

BC30 Bacillus coagulans is generally well tolerated in healthy adults, though the evidence and quality of probiotic products vary. The main safety concern is that live organisms in probiotic preparations can rarely cause serious infection (bacteremia or sepsis) in patients with central lines, severe illness, or weakened immune systems — including preterm infants.

Healthy people with intact immune systems and no indwelling catheters rarely experience this. Because safety data are limited overall, talk to your doctor or pharmacist before starting, especially if you have a weakened immune system or serious illness.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from this product by several hours — antibiotics can kill the live organisms in the formula and reduce its effectiveness. Use the medication search tool on this page to check your exact prescriptions against the Bacillus coagulans ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have constipation or IBS and want to try a probiotic with digestive enzymes, this formula may be worth discussing with your doctor. The key is timing your antibiotics separately from this product if you take them.

If you're severely ill, immunocompromised, or have a central venous catheter, check with your doctor first — probiotics carry a small but real infection risk in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gas Defense Formula, straight from the product label.

Brand Schiff Digestive Advantage
Barcode (UPC) 815066001362
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62646
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gas Defense Formula by Schiff Digestive Advantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
815066001362
IngredientAmount% DV
Invertase0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Alpha-Galactosidase0 NP--
Cellulase0 NP--
BC30 Bacillus coagulans GBI-30, 60860 NP--

Other ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dextrin, Water, Citric Acid, Titanium Dioxide, Sodium Benzoate, Silicon Dioxide, Mannitol, Calcium Gluconate, Magnesium Stearate, ground Limestone, FD&C Red #3, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Galactosemics - Consult your physician.

Contains milk, soy and wheat.

Always consult your pediatrician before giving your child dietary supplements.

Note: If pregnant, lactating or on prescribed medication, consult your physician before using.

Keep out of reach of children.

General Statements

Since 1936

The probiotic that survives

Helps stop intestinal gas before it starts

New look / same great product

Probiotics are beneficial bacteria that live in your digestive tract and promote digestive and immune health. Many other probiotics don't survive the harsh acidic stomach environment.

Actual size

Enjoy the benefits Helps stop intestinal gas before it starts Fast-acting Promotes long-term digestive health with continued use

Survives 10x better

GUARANTEED for purity, freshness and labeled potency.

Survivability and delivery of probiotic cells to the small & large intestines is one of several factors influencing overall product effect.

FDA Statement of Identity

Dietary Suppelment

Brand IP Statement(s)

POWERED BY Ganeden BC30 Probiotic Digestive & Immune health

Schiff Digestive Advantage targets your specific digestive health needs and, with continued use, gives you long-term digestive support.

Because Digestive Advantage Gas Defense Formula reaches your intestines alive, it is able to provide digestive and immune health benefits where you need them.

U.S. patents 6,461,607 & 6,849,256. International patents pending.

Studies reveal that the single strain of probiotic used in Schiff Digestive Advantage survives 10x better than other probiotics and yogurt to deliver good bacteria where you need it.

Based on median % survivability of Digestive Advantage vs. probiotic supplements and 20 probiotic yogurts in simulated gastric pH for 2 hours.

2013 RB

Formula

Ganeden BC30 Probiotic

Contains milk, soy and wheat.

That's because Digestive Advantage contains BC30, a natural probiotic that survives 10x better than yogurt to deliver good bacteria where you need it.

Digestive Advantage Gas Defense Formula provides two powerful ingredients to support your digestive health - enzymes to help reduce gas before it starts by aiding in the breakdown of complex carbohydrates in beans, grains and certain vegetables; and BC30, a natural probiotic to help defend against digestive upsets and bloating.

Suggested/Recommended/Usage/Directions

Directions Adults: Take one capsule daily with water before problem foods. Some individuals may require taking two or more capsules daily depending on intake of problem foods. Children 8 years & over: For children it is recommended that one capsule be opened and contents mixed into food or drink. Upon initial use, it may take 7 to 14 days for you to feel the product working. Consistent, daily use is needed to maintain results.

Just one capsule daily

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

18136 46018136.7

Seals/Symbols

Schiff Quality Guarantee

Formulation

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride). No artificial flavors.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gas Defense Formula by Schiff Digestive Advantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gas Defense Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gas Defense Formula by Schiff Digestive Advantage

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Invertase

0 NP per serving Form: Saccharomyces cerevisiae

Cellulase

0 NP per serving Form: Trichoderma longibrachiatum

Hemicellulase

0 NP per serving Form: Aspergillus niger

Alpha-Galactosidase

0 NP per serving Form: Aspergillus niger

Cellulase

0 NP per serving Form: Aspergillus niger

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dextrin, Water, Citric Acid, Titanium Dioxide, Sodium Benzoate, Silicon Dioxide, Mannitol, Calcium Gluconate, Magnesium Stearate, Ground Limestone, FD&C Red #3, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gas Defense Formula by Schiff Digestive Advantage Drug Interactions

Want to check YOUR meds against Gas Defense Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBI-30, 6086 182

Individual Drug Interactions

The ingredients in Gas Defense Formula interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Gas Defense Formula interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBI-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Gas Defense Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBI-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBI-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gas Defense Formula, from the product label.

Schiff Digestive Advantage

See all Schiff Digestive Advantage products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.DigestiveAdvantage.com
Pharmacist Counseling Corner

Gas Defense Formula by Schiff Digestive Advantage: Common Questions

Does Gas Defense Formula by Schiff Digestive Advantage interact with any medications?
Yes. Based on its ingredients, Gas Defense Formula has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gas Defense Formula contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do the enzymes in this formula do?
The invertase, cellulase, hemicellulase, and alpha-galactosidase break down different types of carbohydrates and fiber in food, which can help reduce the gas and bloating that come from these harder-to-digest carbs.
Does this product work for IBS?
The BC30 Bacillus coagulans ingredient has possibly effective evidence for IBS, which means there's some support for it but more research would help confirm the benefit. Results vary from person to person.
Can I take this with my antibiotic?
You can, but not at the same time. Antibiotics can kill the live organisms in this product, making it less effective. Ask your pharmacist to help you space them out — usually a few hours apart works well.
Is this safe if I have a weak immune system?
Live probiotic products can rarely cause serious infection in people with severely weakened immune systems or indwelling catheters. If you fall into that category, talk to your doctor before using this product.
What are the inactive ingredients?
The formula contains fillers and binders like maltodextrin, microcrystalline cellulose, magnesium stearate, and several others that hold the capsule together and keep it stable — they're not active ingredients.
Is it safe to take during pregnancy or breastfeeding?
The data on file doesn't include pregnancy or breastfeeding safety information for this formula. Talk to your doctor or pharmacist before using it if you're pregnant or nursing — they can help weigh the risks and benefits for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gas Defense Formula is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gas Defense Formula label
Go deeper

The Full Monographs Behind Gas Defense Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Gas Defense Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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